Inhalation of Low-Dose Nitric Oxide to Evaluate Pulmonary Vascular Reactivity in Children with Congenital Heart Disease

1999 ◽  
Vol 20 (4) ◽  
pp. 278-282 ◽  
Author(s):  
T. Yasuda ◽  
N. Tauchi ◽  
R. Baba ◽  
K. Nishibata ◽  
T. Hatano ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Vascular Reactivity ◽  
Low Dose

scholarly journals Very-low-dose inhaled nitric oxide: A selective pulmonary vasodilator after operations for congenital heart disease

1994 ◽  
Vol 108 (3) ◽  
pp. 487-494 ◽  
Author(s):  
O.I. Miller ◽  
D.S. Celermajer ◽  
J.E. Deanfield ◽  
D.J. Macrae
Keyword(s):  
Nitric Oxide ◽  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Low Dose ◽  
Inhaled Nitric Oxide ◽  
Pulmonary Vasodilator

Alterations in ET-1, not nitric oxide, in 1-week-old lambs with increased pulmonary blood flow

2003 ◽  
Vol 284 (2) ◽  
pp. H480-H490 ◽  
Author(s):  
Boaz Ovadia ◽  
Olaf Reinhartz ◽  
Robert Fitzgerald ◽  
Janine M. Bekker ◽  
Michael J. Johengen ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Congenital Heart Disease ◽  
Blood Flow ◽  
Heart Disease ◽  
Endothelial Function ◽  
Pulmonary Blood Flow ◽  
Congenital Heart ◽  
Vascular Reactivity ◽  
Protein Levels ◽  
Vasodilator Response

Altered pulmonary vascular reactivity is a source of morbidity and mortality for children with congenital heart disease and increased pulmonary blood flow. Nitric oxide (NO) and endothelin (ET)-1 are important mediators of pulmonary vascular reactivity. We hypothesize that early alterations in endothelial function contribute to the altered vascular reactivity associated with congenital heart disease. The objective of this study was to characterize endothelial function in our lamb model of increased pulmonary blood flow at 1 wk of life. Eleven fetal lambs underwent in utero placement of an aortopulmonary vascular graft (shunt) and were studied 7 days after delivery. The pulmonary vasodilator response to both intravenous ACh (endothelium dependent) and inhaled NO (endothelium independent) was similar in shunted and control lambs. In addition, tissue NOx, NO synthase (NOS) activity, and endothelial NOS protein levels were similar. Conversely, the vasodilator response to both ET-1 and 4Ala-ET-1 (an ETBreceptor agonist) were attenuated in shunted lambs, and tissue ET-1 concentrations were increased ( P < 0.05). Associated with these changes were an increase in ET-converting enzyme-1 protein and a decrease in ETBreceptor protein levels ( P < 0.05). These data demonstrate that increased pulmonary blood flow induces alterations in ET-1 signaling before NO signaling and suggest an early role for ET-1 in the altered vascular reactivity associated with increased pulmonary blood flow.

scholarly journals Evaluation of oral and low dose intravenous prostaglandin E2 in management of ductus dependent congenital heart disease.

1985 ◽  
Vol 60 (11) ◽  
pp. 1025-1030 ◽  
Author(s):  
E D Silove ◽  
D G Roberts ◽  
J V de Giovanni
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Prostaglandin E2 ◽  
Congenital Heart ◽  
Low Dose

Inhaled nitric oxide to test the vasodilator capacity of the pulmonary vascular bed in children with long-standing pulmonary hypertension and congenital heart disease

1996 ◽  
Vol 77 (7) ◽  
pp. 532-535 ◽  
Author(s):  
Michel Berner ◽  
Maurice Beghetti ◽  
Isabelle Spahr-Schopfer ◽  
Ingrid Oberhansli ◽  
Beat Friedli
Keyword(s):  
Nitric Oxide ◽  
Congenital Heart Disease ◽  
Pulmonary Hypertension ◽  
Heart Disease ◽  
Congenital Heart ◽  
Inhaled Nitric Oxide ◽  
Vascular Bed ◽  
Pulmonary Vascular Bed

Cardiovascular computed tomography angiography in newborns and infants with suspected congenital heart disease: retrospective evaluation of low-dose scan protocols

2012 ◽  
Vol 36 (6) ◽  
pp. 746-753 ◽  
Author(s):  
Thorsten Klink ◽  
Götz Müller ◽  
Jochen Weil ◽  
Ali Dodge-Khatami ◽  
Gerhard Adam ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Congenital Heart Disease ◽  
Heart Disease ◽  
Computed Tomography Angiography ◽  
Congenital Heart ◽  
Low Dose ◽  
Retrospective Evaluation

scholarly journals Comparison of the Acute Pulmonary Vasodilating Effect of Beraprost Sodium and Nitric Oxide in Congenital Heart Disease

2005 ◽  
Vol 69 (1) ◽  
pp. 61-64 ◽  
Author(s):  
Kritvikrom Durongpisitkul ◽  
Duangmanee Laoprasitiporn ◽  
Thanarat Layangool ◽  
Rekwan Sittiwankul ◽  
Mannat Panamonta ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Beraprost Sodium ◽  
Vasodilating Effect

scholarly journals EXPOSURE TO LOW-DOSE IONIZING RADIATION FROM CARDIAC PROCEDURES AND RISK OF MALIGNANCY IN CHILDREN WITH CONGENITAL HEART DISEASE

2020 ◽  
Vol 75 (11) ◽  
pp. 545
Author(s):  
Elie Ganni ◽  
Aihua Liu ◽  
Liming Guo ◽  
Yixuan Li ◽  
Yajie Tian ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Ionizing Radiation ◽  
Congenital Heart ◽  
Low Dose ◽  
Cardiac Procedures ◽  
Risk Of Malignancy
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