Musculoskeletal imaging features of non-Langerhans cell histiocytoses

AbstractEvaluation and characterization of skeletal muscle pathology is a frequently encountered indication for musculoskeletal imaging. Causes of muscle pathology are diverse and include traumatic, autoimmune, infectious, inflammatory, neurologic, and neoplastic. Each etiology while dramatically different in the pathophysiology may present with similar imaging features. An understanding of the subtle differences in imaging features between the pathologic conditions may serve to guide diagnosis and treatment in these often complex cases. In this section, we will discuss the various skeletal muscle pathologies and the imaging features associated with each.

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MR imaging features of orbital Langerhans cell Histiocytosis

BMC Ophthalmology ◽

10.1186/s12886-019-1269-9 ◽

2019 ◽

Vol 19 (1) ◽

Cited By ~ 2

Author(s):

Chunnan Wu ◽

Kuncheng Li ◽

Yan Hei ◽

Pengyu Lan ◽

Xuetao Mu

Keyword(s):

Mr Imaging ◽

Diagnostic Accuracy ◽

Langerhans Cell Histiocytosis ◽

Clinical Manifestations ◽

Langerhans Cell ◽

Imaging Features ◽

Mri Findings ◽

Palpable Mass ◽

Hyperintense Signal ◽

Mri Features

Abstract Background To investigate the magnetic resonance imaging (MRI) features of orbital Langerhans cell histiocytosis (LCH) to improve diagnostic accuracy. Methods We retrospectively reviewed clinical manifestations and MRI findings of 23 patients with histopathology-confirmed LCH of the orbit. The findings were evaluated for the following: (a) symptoms, (b) disease duration, (c) location, (d) configuration, (e) margin, (f) MR imaging signal intensity and enhanced performance. Results Eighteen patients (78%) in our series were male, only five (22%) patients were female, and the mean age at presentation was 6.3 years. The common symptoms include swollen eyelids, exophthalmos, and a palpable mass. Fourteen patients presented with swollen eyelids and/or exophthalmos. Twenty-two cases involved unilateral orbits, and one case involved bilateral orbits. In our study, there was one patient with cough and expectoration, and one patient with polydipsia and polyuria. Lesions were located in the superior or superlateral orbital roof of seventeen patients (74%). Lesions formed masses or irregular shapes. The 12 out of 23 (52.2%) cases appeared heterogeneous isointense and 10 out of 23 (43.5%) cases showed iso-hypointense on T1-weighted imaging, there were 15 out of 23 (65.2%) cases showed hyper-hypointense mixed signals on T2-weighted imaging. 7 cases found patchy hyperintense signal on T1WI, and 11 cases showed markedly hyperintense signal near the edge of lesions on T2WI. After enhancement, 21 out of 23 (91.3%) cases lesions presented marked enhancement at the edges and the surrounding tissues, and with heterogeneous obvious enhancement of the lesion center. Besides, four cases lesions were surrounded by a low circular signal. Conclusion There were several characteristics MRI features that can provide crucial information for clinicians and improve our understanding and the diagnostic accuracy of the orbital LCH.

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MR Imaging Features of Orbital Langerhans Cell Histiocytosis

10.21203/rs.2.1756/v3 ◽

2019 ◽

Author(s):

chunnan wu ◽

xuetao Mu ◽

yan Hei ◽

pengyu lan ◽

kuncheng li

Keyword(s):

Mr Imaging ◽

Diagnostic Accuracy ◽

Langerhans Cell Histiocytosis ◽

Clinical Manifestations ◽

Langerhans Cell ◽

Imaging Features ◽

Mri Findings ◽

Palpable Mass ◽

Hyperintense Signal ◽

Mri Features

Abstract Background: To investigate the magnetic resonance imaging (MRI) features of orbital Langerhans cell histiocytosis (LCH) to improve diagnostic accuracy. Methods: We retrospectively reviewed clinical manifestations and MRI findings of 23 patients with histopathology-confirmed LCH of the orbit. The findings were evaluated for the following: (a) symptoms, (b) disease duration，(c) location, (d) configuration, (e) margin, (f) MR imaging signal intensity and enhanced performance. Results: Eighteen patients (78%) in our series were male, only five (22%) patients were female, and the mean age at presentation was 6.3 years. The common symptoms include swollen eyelids, exophthalmos, and a palpable mass. Fourteen patients presented with swollen eyelids and/or exophthalmos. Twenty-two cases involved unilateral orbits, and one case involved bilateral orbits. In our study, there was one patient with cough and expectoration, and one patient with polydipsia and polyuria. Lesions were located in the superior or superlateral orbital roof of seventeen patients (74%). Lesions formed masses or irregular shapes. The 12 out of 23 (52.2%)cases appeared heterogeneous isointense and 10 out of 23 (43.5%) cases showed iso-hypointense on T1-weighted imaging, there were 15 out of 23 (65.2%) cases showed hyper-hypointense mixed signals on T2-weighted imaging. 7 cases found patchy hyperintense signal on T1WI, and 11 cases showed markedly hyperintense signal near the edge of lesions on T2WI. After enhancement, 21 out of 23 (91.3%) cases lesions presented marked enhancement at the edges and the surrounding tissues, and with heterogeneous obvious enhancement of the lesion center. Besides, four cases lesions were surrounded by a low circular signal. Conclusion: There were several characteristics MRI features that can provide crucial information for clinicians and improve our understanding and the diagnostic accuracy of the orbital LCH.

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MR Imaging Features of Orbital Langerhans Cell Histiocytosis

10.21203/rs.2.1756/v2 ◽

2019 ◽

Author(s):

chunnan wu ◽

xuetao Mu ◽

yan Hei ◽

pengyu lan ◽

kuncheng li

Keyword(s):

Mr Imaging ◽

Diagnostic Accuracy ◽

Langerhans Cell Histiocytosis ◽

Clinical Manifestations ◽

Langerhans Cell ◽

Imaging Features ◽

Mri Findings ◽

Palpable Mass ◽

Orbital Roof ◽

Mri Features

Abstract Background: To investigate the magnetic resonance imaging (MRI) features of orbital Langerhans cell histiocytosis (LCH) to improve diagnostic accuracy. Methods: We retrospectively reviewed clinical manifestations and MRI findings of 23 patients with histology-confirmed LCH of the orbit. The findings were evaluated for the following: (a) symptoms, (b) disease duration，(c) location, (d) configuration, (e) margin, (f) MR imaging signal intensity and enhanced performance. Results: Eighteen patients (78%) in our series were male, only five (22%) patients were female, and the mean age at presentation was 6.3 years. The common symptoms include swollen eyelids, exophthalmos, and a palpable mass. Fourteen patients presented with swollen eyelids and/or exophthalmos. Twenty-two cases involved unilateral orbits, and one case involved bilateral orbits. In our study, there was one patient with cough and expectoration, and one patient with polydipsia and polyuria. Lesions were located in the superior or superlateral orbital roof of seventeen patients (74%). Lesions formed masses or irregular shapes. The majority of lesions appeared heterogeneous isointense and iso-hypointense on T1-weighted imaging and hyper-hypointense mixed signals on T2-weighted imaging. The appearance of hemorrhage and cystic change were usually seen in lesions. After enhancement, majority lesions presented marked enhancement at the edges and the surrounding tissues, and with heterogeneous obvious enhancement of the lesion center. Besides, several lesions were surrounded by a low circular signal. Conclusion: There were several characteristics MRI features that can provide crucial information for clinicians and improve our understanding and the diagnostic accuracy of the orbital LCH

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MR Imaging Features of Orbital Langerhans Cell Histiocytosis

10.21203/rs.2.1756/v5 ◽

2019 ◽

Author(s):

chunnan wu ◽

xuetao Mu ◽

yan Hei ◽

pengyu lan ◽

kuncheng li

Keyword(s):

Mr Imaging ◽

Diagnostic Accuracy ◽

Langerhans Cell Histiocytosis ◽

Clinical Manifestations ◽

Langerhans Cell ◽

Imaging Features ◽

Mri Findings ◽

Palpable Mass ◽

Hyperintense Signal ◽

Mri Features

Abstract Background: To investigate the magnetic resonance imaging (MRI) features of orbital Langerhans cell histiocytosis (LCH) to improve diagnostic accuracy. Methods: We retrospectively reviewed clinical manifestations and MRI findings of 23 patients with histopathology-confirmed LCH of the orbit. The findings were evaluated for the following: (a) symptoms, (b) disease duration，(c) location, (d) configuration, (e) margin, (f) MR imaging signal intensity and enhanced performance. Results: Eighteen patients (78%) in our series were male, only five (22%) patients were female, and the mean age at presentation was 6.3 years. The common symptoms include swollen eyelids, exophthalmos, and a palpable mass. Fourteen patients presented with swollen eyelids and/or exophthalmos. Twenty-two cases involved unilateral orbits, and one case involved bilateral orbits. In our study, there was one patient with cough and expectoration, and one patient with polydipsia and polyuria. Lesions were located in the superior or superlateral orbital roof of seventeen patients (74%). Lesions formed masses or irregular shapes. The 12 out of 23 (52.2%)cases appeared heterogeneous isointense and 10 out of 23 (43.5%) cases showed iso-hypointense on T1-weighted imaging, there were 15 out of 23 (65.2%) cases showed hyper-hypointense mixed signals on T2-weighted imaging. 7 cases found patchy hyperintense signal on T1WI, and 11 cases showed markedly hyperintense signal near the edge of lesions on T2WI. After enhancement, 21 out of 23 (91.3%) cases lesions presented marked enhancement at the edges and the surrounding tissues, and with heterogeneous obvious enhancement of the lesion center. Besides, four cases lesions were surrounded by a low circular signal. Conclusion: There were several characteristics MRI features that can provide crucial information for clinicians and improve our understanding and the diagnostic accuracy of the orbital LCH.

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MR Imaging Features of Orbital Langerhans Cell Histiocytosis

10.21203/rs.2.1756/v4 ◽

2019 ◽

Author(s):

chunnan wu ◽

xuetao Mu ◽

yan Hei ◽

pengyu lan ◽

kuncheng li

Keyword(s):

Mr Imaging ◽

Diagnostic Accuracy ◽

Langerhans Cell Histiocytosis ◽

Clinical Manifestations ◽

Langerhans Cell ◽

Imaging Features ◽

Mri Findings ◽

Palpable Mass ◽

Hyperintense Signal ◽

Mri Features

Abstract Background: To investigate the magnetic resonance imaging (MRI) features of orbital Langerhans cell histiocytosis (LCH) to improve diagnostic accuracy. Methods: We retrospectively reviewed clinical manifestations and MRI findings of 23 patients with histopathology-confirmed LCH of the orbit. The findings were evaluated for the following: (a) symptoms, (b) disease duration，(c) location, (d) configuration, (e) margin, (f) MR imaging signal intensity and enhanced performance. Results: Eighteen patients (78%) in our series were male, only five (22%) patients were female, and the mean age at presentation was 6.3 years. The common symptoms include swollen eyelids, exophthalmos, and a palpable mass. Fourteen patients presented with swollen eyelids and/or exophthalmos. Twenty-two cases involved unilateral orbits, and one case involved bilateral orbits. In our study, there was one patient with cough and expectoration, and one patient with polydipsia and polyuria. Lesions were located in the superior or superlateral orbital roof of seventeen patients (74%). Lesions formed masses or irregular shapes. The 12 out of 23 (52.2%)cases appeared heterogeneous isointense and 10 out of 23 (43.5%) cases showed iso-hypointense on T1-weighted imaging, there were 15 out of 23 (65.2%) cases showed hyper-hypointense mixed signals on T2-weighted imaging. 7 cases found patchy hyperintense signal on T1WI, and 11 cases showed markedly hyperintense signal near the edge of lesions on T2WI. After enhancement, 21 out of 23 (91.3%) cases lesions presented marked enhancement at the edges and the surrounding tissues, and with heterogeneous obvious enhancement of the lesion center. Besides, four cases lesions were surrounded by a low circular signal. Conclusion: There were several characteristics MRI features that can provide crucial information for clinicians and improve our understanding and the diagnostic accuracy of the orbital LCH.

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