scholarly journals Muscle Imaging

2021 ◽  
pp. 247-258
Author(s):  
William Palmer ◽  
M. K. Jesse
Keyword(s):  
Skeletal Muscle ◽  
Diagnosis And Treatment ◽  
Musculoskeletal Imaging ◽  
Muscle Pathology ◽  
Imaging Features ◽  
Complex Cases ◽  
Similar Imaging

AbstractEvaluation and characterization of skeletal muscle pathology is a frequently encountered indication for musculoskeletal imaging. Causes of muscle pathology are diverse and include traumatic, autoimmune, infectious, inflammatory, neurologic, and neoplastic. Each etiology while dramatically different in the pathophysiology may present with similar imaging features. An understanding of the subtle differences in imaging features between the pathologic conditions may serve to guide diagnosis and treatment in these often complex cases. In this section, we will discuss the various skeletal muscle pathologies and the imaging features associated with each.

scholarly journals Characterization of Ross River Virus Tropism and Virus-Induced Inflammation in a Mouse Model of Viral Arthritis and Myositis

2006 ◽  
Vol 80 (2) ◽  
pp. 737-749 ◽  
Author(s):  
Thomas E. Morrison ◽  
Alan C. Whitmore ◽  
Reed S. Shabman ◽  
Brett A. Lidbury ◽  
Suresh Mahalingam ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Mouse Model ◽  
Nk Cells ◽  
Muscle Pathology ◽  
Ross River Virus ◽  
Adaptive Immune ◽  
Arthritic Disease ◽  
Rag 1 ◽  
Inflammatory Macrophages

ABSTRACT Mosquito-borne alphaviruses are a significant cause of both encephalitic and arthritic disease in humans worldwide. In contrast to the encephalitic alphaviruses, the pathogenesis of alphavirus-induced arthritic disease is not well understood. Utilizing a mouse model of Ross River virus (RRV) disease, we found that the primary targets of RRV infection are bone, joint, and skeletal muscle tissues of the hind limbs in both outbred CD-1 mice and adult C57BL/6J mice. Moreover, histological analyses demonstrated that RRV infection resulted in severe inflammation of these tissues. Characterization of the inflammatory infiltrate within the skeletal muscle tissue identified inflammatory macrophages, NK cells, and CD4+ and CD8+ T lymphocytes. To determine the contribution of the adaptive immune system, the outcome of RRV-induced disease was examined in C57BL/6J RAG-1−/− mice, which lack functional T and B lymphocytes. RAG-1−/− and wild-type mice developed similar disease signs, infiltration of inflammatory macrophages and NK cells, and muscle pathology, suggesting that the adaptive immune response does not play a critical role in the development of disease. These results establish the mouse model of RRV disease as a useful system for the identification of viral and host factors that contribute to alphavirus-induced arthritis and myositis.

Skeletal Muscle Pathology

Pathology ◽  
1983 ◽  
Vol 15 (4) ◽  
pp. 511
Author(s):  
J.G. McLeod
Keyword(s):  
Skeletal Muscle ◽  
Muscle Pathology
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