A functional recombinant single-chain T cell receptor fragment capable of selectively targeting antigen-presenting cells

2002 ◽  
Vol 51 (10) ◽  
pp. 565-573 ◽  
Author(s):  
Malka Epel ◽  
Joshua Ellenhorn ◽  
Don Diamond ◽  
Yoram Reiter
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Antigen Presenting Cells ◽  
Cell Receptor ◽  
Single Chain ◽  
Antigen Presenting ◽  
Receptor Fragment

scholarly journals A soluble, single-chain T-cell receptor fragment endowed with antigen-combining properties.

1991 ◽  
Vol 88 (19) ◽  
pp. 8646-8650 ◽  
Author(s):  
J. Novotny ◽  
R. K. Ganju ◽  
S. T. Smiley ◽  
R. E. Hussey ◽  
M. A. Luther ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Single Chain ◽  
Receptor Fragment

Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells

Nature ◽  
1993 ◽  
Vol 363 (6425) ◽  
pp. 156-159 ◽  
Author(s):  
Joanne Sloan-Lancaster ◽  
Brian D. Evavold ◽  
Paul M. Allen
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Antigen Presenting Cells ◽  
Cell Receptor ◽  
Receptor Ligand ◽  
T Cell Anergy ◽  
Cell Anergy ◽  
Antigen Presenting

scholarly journals T Cells Can Use Either T Cell Receptor or Cd28 Receptors to Absorb and Internalize Cell Surface Molecules Derived from Antigen-Presenting Cells

2000 ◽  
Vol 191 (7) ◽  
pp. 1137-1148 ◽  
Author(s):  
Inkyu Hwang ◽  
Jing-Feng Huang ◽  
Hidehiro Kishimoto ◽  
Anders Brunmark ◽  
Per A. Peterson ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
T Cell Receptor ◽  
Biological Significance ◽  
Antigen Presenting Cells ◽  
Cell Receptor ◽  
Cell Uptake ◽  
Lymphocyte Function ◽  
Activated T Cells ◽  
Antigen Presenting

At the site of contact between T cells and antigen-presenting cells (APCs), T cell receptor (TCR)–peptide–major histocompatibility complex (MHC) interaction is intensified by interactions between other molecules, notably by CD28 and lymphocyte function-associated antigen 1 (LFA-1) on T cells interacting with B7 (B7-1 and B7-2), and intracellular adhesion molecule 1 (ICAM-1), respectively, on APCs. Here, we show that during T cell–APC interaction, T cells rapidly absorb various molecules from APCs onto the cell membrane and then internalize these molecules. This process is dictated by at least two receptors on T cells, namely CD28 and TCR molecules. The biological significance of T cell uptake of molecules from APCs is unclear. One possibility is that this process may allow activated T cells to move freely from one APC to another and eventually gain entry into the circulation.

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