Esophageal dysmotility and lung disease in patients with systemic sclerosis: is there a possible association or correlation? A retrospective chart review

2021 ◽  
Author(s):  
Navya Kuchipudi ◽  
Shweta Kishore ◽  
Chia-Ling Kuo ◽  
Santhanam Lakshminarayanan ◽  
Ranadeep Mandhadi
Keyword(s):  
Systemic Sclerosis ◽  
Lung Disease ◽  
Chart Review ◽  
Retrospective Chart Review ◽  
Esophageal Dysmotility

scholarly journals Assessment Of Ratio Of Peak Expiratory Flow Rate To Vital Capacity For Identifying Pulmonary Fibrosis

2021 ◽  
Vol 44 (1) ◽  
pp. E25-27
Author(s):  
Stacey D. Lok ◽  
Donald W. Cockcroft ◽  
Alexander Simidchiev
Keyword(s):  
Pulmonary Fibrosis ◽  
Lung Disease ◽  
Peak Expiratory Flow ◽  
Chart Review ◽  
Vital Capacity ◽  
Retrospective Chart Review ◽  
High Specificity ◽  
Expiratory Flow ◽  
Function Testing ◽  
Expiratory Flow Rates

Background: Pulmonary fibrosis (PF) is associated with reduction in vital capacity (VC) and increase in expiratory flow rates, including peak expiratory flow (PEF). Full pulmonary function testing and computed tomography chest scans are limited resources in some geographic areas and a simple and sensitive screening test would be of value. We hypothesized that increase in the ratio of % predicted PEF over % predicted VC (%PEF/%VC), from spirometry alone might be sensitive to screen for pulmonary fibrosis. Methods: The %PEF/%VC from 1,000 consecutive spirometric flow volume curves was nearly normally distributed: 7.5% (approximately 1.5 standard deviations) had a ratio ≥ 1.4. We evaluated the sensitivity and specificity of this cut point for a diagnosis of PF in a retrospective chart review of 391 patients with good quality spirometry and respirologists’ confirmed diagnoses. Results: Of the 391 patients analyzed, 98 had PF, 79 were normal, 70 had a combined obstructive and restrictive processes, 57 had obstructive lung disease, 61 had extra-parenchymal restriction and 26 had non-fibrotic interstitial lung disease. A %PEF/%VC ≥ 1.4 was only 54.1% sensitive in predicting PF, however it had a specificity of 94.9%. There was a 95.1% specificity for ruling in intra-parenchymal opposed to extra-parenchymal restriction. Conclusion: A %PEF/%VC ≥ 1.4 was not sensitive enough to screen for PF but did demonstrate high specificity and thus may be helpful in identifying intraparenchymal restriction.

A Case of Systemic Sclerosis with Interstitial Lung Disease Successfully Treated with Intravenous Cyclophosphamide Pulse Therapy and Oral Azathioprine

2016 ◽  
Vol 78 (4) ◽  
pp. 356-361
Author(s):  
Kei YAMAUCHI ◽  
Katsunari MAKINO ◽  
Takamitsu MAKINO ◽  
Satoshi FUKUSHIMA ◽  
Masatoshi JINNIN ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Pulse Therapy ◽  
Intravenous Cyclophosphamide ◽  
Cyclophosphamide Pulse Therapy ◽  
Cyclophosphamide Pulse

Improvement of Systemic Sclerosis Complicated with Interstitial Lung Disease by Intravenous Pulse Therapy with Cyclophosphamide

2006 ◽  
Vol 68 (3) ◽  
pp. 256-259 ◽  
Author(s):  
Yumi MURASE ◽  
Jun KURODA ◽  
Yoshinao MURO ◽  
Yasushi TOMITA
Keyword(s):  
Systemic Sclerosis ◽  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Pulse Therapy
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