Healed neointima of in-stent restenosis lesions in patients with stable angina pectoris: an intracoronary optical coherence tomography study

2022 ◽  
Author(s):  
Hideo Amano ◽  
Yoshimasa Kojima ◽  
Shojiro Hirano ◽  
Yosuke Oka ◽  
Hiroto Aikawa ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Angina Pectoris ◽  
Stable Angina ◽  
Optical Coherence ◽  
Stable Angina Pectoris ◽  
Stent Restenosis ◽  
In Stent Restenosis

Usefulness of endothelinA receptor antagonists for the prevention of in-stent restenosis in patients with stable angina pectoris or silent myocardial ischemia

2003 ◽  
Vol 91 (4) ◽  
pp. 476-479 ◽  
Author(s):  
Zenon S. Kyriakides ◽  
Stavroula N. Psychari ◽  
Theofilos M. Kolettis ◽  
Michael Georgiadis ◽  
Aias Antoniadis ◽  
...  
Keyword(s):  
Angina Pectoris ◽  
Myocardial Ischemia ◽  
Stable Angina ◽  
Silent Myocardial Ischemia ◽  
Stable Angina Pectoris ◽  
Receptor Antagonists ◽  
Stent Restenosis ◽  
In Stent Restenosis

Abstract 3324: Assessment of Coronary Calcification by Optical Coherence Tomography in the Culprit Lesions: Comparison between Acute Coronary Syndrome and Stable Angina Pectoris

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Masato Mizukoshi ◽  
Takashi Kubo ◽  
Shigeho Takarada ◽  
Hironori Kitabata ◽  
Takashi Tanimoto ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Angina Pectoris ◽  
Stable Angina ◽  
Optical Coherence ◽  
Luminal Surface ◽  
Culprit Lesion ◽  
Stable Angina Pectoris ◽  
Calcium Deposit ◽  
Spotty Calcification ◽  
Calcium Deposits

[BACKGROUND] Calcification is an important phenomenon of atherosclerosis. Histopathological and intravascular ultrasound studies suggest that the characteristics of calcification might be associated with the pathogenesis of the vulnerable plaque. Optical coherence tomography (OCT) is a high-resolution imaging modality and allows us to analyse the plaque morphology in detail. In this study, we assessed the characteristics of calcification by OCT at the sites of culprit lesions in acute myocardial infarction (AMI), unstable angina pectoris (UAP), and stable angina pectoris (SAP). [METHOD and RESULTS] We evaluated the characteristics of calcification in the 20-mm-long culprit lesion segment per patient by OCT in 56 patients (AMI : n=21, UAP : n=14, SAP : n=21). In each patient, the number of calcium deposits, the arc, the distance from the luminal surface to each calcification were measured. Each calcium deposit was categorized into one of two groups by the arc : spotty calcification : a small calcium deposit with an arc of less than 90 degrees ; large calcification : a calcific lesion with an arc of more than 90 degrees. The average number of spotty calcification per patient in AMI and UAP was significantly greater than that in SAP (AMI 1.7+/−1.3, UAP 1.9+/−1.7, and SAP 0.6+/−0.8, p=0.012; AMI vs SAP, p=0.046, UAP vs SAP, p=0.030). The average number of large calcification per patient in AMI was significantly lower than that in SAP (AMI0.2+/−0.4, UAP 0.42+/−0.7, and SAP0.9+/−0.7; AMI vs SAP, p=0.005). Consequently, the percent of spotty calcification in each culprit lesion was higher in AMI and UAP than in SAP (AMI 87.5%, UAP 81.3%, and SAP40.1%, p<0.01). The distance between the luminal surface and the inner edge of each spotty calcification was significantly shorter in AMI and UAP than in SAP (AMI 0.18+/−0.11mm, UAP 0.15+/−0.1mm, SAP 0.30+/−0.13mm, p<0.001; AMI vs SAP, p=0.007, and UAP vs SAP, p=0.001), but that of each large calcification was not significantly different among AMI, UAP, and SAP. [CONCLUSION] In the culprit lesions of AMI and UAP, calcium deposits more spotty in size and more close to the lumen would be observed frequently. These characteristics of the calcium deposition might play an important role in the pathogenesis of the plaque vulnerability.

scholarly journals Prevalence and Clinical Significance of Layered Plaque in Patients With Stable Angina Pectoris　― Evaluation With Histopathology and Optical Coherence Tomography ―

2019 ◽  
Vol 83 (12) ◽  
pp. 2452-2459 ◽  
Author(s):  
Hiroshi Okamoto ◽  
Teruyoshi Kume ◽  
Ryotaro Yamada ◽  
Terumasa Koyama ◽  
Tomoko Tamada ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Angina Pectoris ◽  
Clinical Significance ◽  
Stable Angina ◽  
Optical Coherence ◽  
Stable Angina Pectoris

scholarly journals Predictors of In-Stent Restenosis in Patients With Stable Angina Pectoris

Angiology ◽  
2017 ◽  
Vol 68 (9) ◽  
pp. 831-831 ◽  
Author(s):  
Samet Yilmaz ◽  
Mehmet Kadri Akboga ◽  
Serkan Topaloglu
Keyword(s):  
Angina Pectoris ◽  
Stable Angina ◽  
Stable Angina Pectoris ◽  
Stent Restenosis ◽  
In Stent Restenosis

scholarly journals Severely Circumferentially Calcified Neointima as a New Cause of Undilatable In-Stent Restenosis

2018 ◽  
Vol 2018 ◽  
pp. 1-3
Author(s):  
Manabu Kashiwagi ◽  
Takashi Tanimoto ◽  
Hironori Kitabata
Keyword(s):  
Optical Coherence Tomography ◽  
Angina Pectoris ◽  
Coronary Angiography ◽  
Balloon Angioplasty ◽  
Balloon Dilatation ◽  
Optical Coherence ◽  
Stent Restenosis ◽  
Scoring Balloon ◽  
Recurrent Angina ◽  
In Stent Restenosis

A 74-year old man presented recurrent angina pectoris due to in-stent restenosis (ISR) with severely calcified neointima. In-stent neoatherosclerosis (NA) is associated with late stent failure, and NA with calcified neointima occurs in some cases. Because the presence of neointimal calcification could lead to underexpansion of newly implanted stent for ISR, a scoring balloon was selected for predilatation to obtain maximum extrusion of the neointimal plaque and subsequently, an everolimus-eluting stent was implanted. However, moderate stenosis remained on coronary angiography, and optical coherence tomography (OCT) revealed underexpansion of the newly implanted stent because an attempt at balloon dilatation of neointimal calcification failed. Although OCT can clearly discriminate stent struts from neointimal calcification, we did not perform OCT assessment between scoring balloon and stenting. It is highly recommended to confirm whether the lesion is adequately treated by balloon angioplasty before stenting in cases with calcified ISR.

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