Oncological outcomes of lateral lymph node dissection (LLND) for locally advanced rectal cancer: is LLND alone sufficient?

2020 ◽  
Author(s):  
Atsushi Ishibe ◽  
Jun Watanabe ◽  
Yusuke Suwa ◽  
Shinsuke Suzuki ◽  
Kazuya Nakagawa ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Lymph Node ◽  
Lymph Node Dissection ◽  
Locally Advanced ◽  
Advanced Rectal Cancer ◽  
Locally Advanced Rectal Cancer ◽  
Lateral Lymph Node Dissection ◽  
Node Dissection ◽  
Lateral Lymph Node ◽  
Oncological Outcomes

Oncological outcomes of robotic-assisted laparoscopic versus open lateral lymph node dissection for locally advanced low rectal cancer

2018 ◽  
Vol 32 (11) ◽  
pp. 4498-4505 ◽  
Author(s):  
Tomohiro Yamaguchi ◽  
Yusuke Kinugasa ◽  
Akio Shiomi ◽  
Hiroyasu Kagawa ◽  
Yushi Yamakawa ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Lymph Node ◽  
Lymph Node Dissection ◽  
Locally Advanced ◽  
Low Rectal Cancer ◽  
Lateral Lymph Node Dissection ◽  
Node Dissection ◽  
Lateral Lymph Node ◽  
Robotic Assisted ◽  
Oncological Outcomes

Lateral lymph node dissection after neoadjuvant (chemo)radiotherapy may improve oncological outcomes in Western patients with low rectal cancer.

2020 ◽  
Vol 38 (4_suppl) ◽  
pp. 163-163 ◽  
Author(s):  
Hidde Maarten Kroon ◽  
Songphol Malakorn ◽  
Nagendra N Dudi-Venkata ◽  
Sergei Bedrikovetski ◽  
Jianliang Liu ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Lymph Node ◽  
Adjuvant Chemotherapy ◽  
Lymph Node Dissection ◽  
Local Recurrence Rate ◽  
Lateral Lymph Node Dissection ◽  
Short Axis ◽  
Node Dissection ◽  
Lateral Lymph Node ◽  
Oncological Outcomes

163 Background: In the West, rectal cancer patients with pre-treatment abnormal lateral lymph nodes (LLN) are commonly treated with neoadjuvant (chemo)radiotherapy (n(C)RT) followed by total mesorectal excision (TME). Few centers perform lateral lymph node dissection (LLND) in addition to this, with the aim of improving oncological outcomes. To date, no comparative data are available in Western patients. Methods: An international multi-center cohort study was conducted comparing six centers from the Netherlands and Australia treating patients with abnormal LLN (≥5mm short-axis) with n(C)RT and TME (LLND- group) versus similarly staged patients from a dedicated cancer center in the USA who underwent a LLND in addition to n(C)RT and TME (LLND+ group). Results: Data were available on 169 patients. LLND+ patients (n = 44) consisted of significantly younger and more female patients with higher ASA-scores and ypN-stages compared to LLND- patients (n = 115). LLND+ patients also had a larger median LLN short-axis and were more likely to receive adjuvant chemotherapy (100 vs. 30%; p < 0.0001). Between groups, the lateral local recurrence rate (LLRR) was 0% for LLND+ vs. 7% for LLND- (p = 0.09) and the local recurrence rate (LRR) was 3% for LLND+ vs. 11% for LLND- (p = 0.13). No significant differences were observed in disease-free survival (DFS, p = 0.94) or overall survival (OS, p = 0.42). Sub-analysis of patients who underwent adjuvant chemotherapy (LLND- patients: n = 35) demonstrated clinically relevant though non-statistically significant trends towards a lower LLRR (0% for LLND+ vs. 6% for LLND-; p = 0.07), LRR (3% for LLND+ vs. 14% for LLND-; p = 0.06), DFS (p = 0.19) and OS (p = 0.17) in favour of the LLND+ group. Conclusions: Lateral lymph node dissection in addition to neoadjuvant (chemo)radiotherapy may improve oncological outcomes in Western patients with low rectal cancer and abnormal lateral lymph nodes.

Laparoscopic Versus Open Lateral Lymph Node Dissection for Locally Advanced Low Rectal Cancer

2017 ◽  
Vol 60 (9) ◽  
pp. 954-964 ◽  
Author(s):  
Tomohiro Yamaguchi ◽  
Tsuyoshi Konishi ◽  
Yusuke Kinugasa ◽  
Seiichiro Yamamoto ◽  
Takashi Akiyoshi ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Lymph Node ◽  
Lymph Node Dissection ◽  
Locally Advanced ◽  
Low Rectal Cancer ◽  
Lateral Lymph Node Dissection ◽  
Node Dissection ◽  
Lateral Lymph Node

scholarly journals Laparoscopic lateral lymph node dissection in two fascial spaces for locally advanced lower rectal cancer

2021 ◽  
Vol 27 (24) ◽  
pp. 3654-3667
Author(s):  
Hui-Hong Jiang ◽  
Hai-Long Liu ◽  
A-Jian Li ◽  
Wen-Chao Wang ◽  
Liang Lv ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Lymph Node ◽  
Lymph Node Dissection ◽  
Locally Advanced ◽  
Lateral Lymph Node Dissection ◽  
Lower Rectal Cancer ◽  
Node Dissection ◽  
Lateral Lymph Node ◽  
Fascial Spaces

Oncological Impact of Lateral Lymph Node Dissection After Preoperative Chemoradiotherapy in Patients with Rectal Cancer

2020 ◽  
Vol 27 (9) ◽  
pp. 3525-3533
Author(s):  
Min Jung Kim ◽  
George J. Chang ◽  
Han-Ki Lim ◽  
Mi Kyung Song ◽  
Sung Chan Park ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Lymph Node ◽  
Lymph Node Dissection ◽  
Preoperative Chemoradiotherapy ◽  
Lateral Lymph Node Dissection ◽  
Node Dissection ◽  
Lateral Lymph Node
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