Rectal Cancer
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2021 ◽  
Vol 9 (29) ◽  
pp. 8923-8931
Yoshikuni Yonenaga ◽  
Satoshi Yokoyama

2021 ◽  
Vol 13 (10) ◽  
pp. 1412-1424
Shimpei Ogawa ◽  
Michio Itabashi ◽  
Yuji Inoue ◽  
Takeshi Ohki ◽  
Yoshiko Bamba ◽  

2021 ◽  
Vol 15 (6) ◽  
Sharlyn Kang ◽  
Kate Wilkinson ◽  
Daniel Brungs ◽  
Wei Chua ◽  
Weng Ng ◽  

2021 ◽  
Vol 27 (38) ◽  
pp. 6374-6386
Roberto Peltrini ◽  
Mauro Podda ◽  
Simone Castiglioni ◽  
Maria Michela Di Nuzzo ◽  
Michele D'Ambra ◽  

Toru Tochigi ◽  
Sophia C. Kamran ◽  
Anushri Parakh ◽  
Yoshifumi Noda ◽  
Balaji Ganeshan ◽  

2021 ◽  
Tatsuya Manabe ◽  
Yusuke Mizuuchi ◽  
Yasuhiro Tsuru ◽  
Hiroshi Kitagawa ◽  
Takaaki Fujimoto ◽  

Abstract Background: In contrast to open-surgery abdominoperineal excision (APE) for rectal cancer, postoperative perineal hernia (PPH) is reported to increase after extralevator APE and endoscopic surgery. In this study, therefore, we aimed to determine the risk factors for PPH after endoscopic APE.Methods: A total 73 patients who underwent endoscopic APE for lower rectal cancer were collected from January 2009 to March 2020, and the risk factors for PPH were analyzed retrospectively.Results: Nineteen patients (26%) developed PPH after endoscopic APE, and the diagnosis of PPH was made at 9–393 days (median: 183 days) after initial surgery. Logistic regression analysis showed that absence of pelvic peritoneal closure alone increased the incidence of PPH significantly (odds ratio; 13.76, 95% confidence interval; 1.48–1884.84, p = 0.004).Conclusions: Pelvic peritoneal closure should be performed when possible after endoscopic APE to prevent PPH.

Kent J. Peterson ◽  
Jacqueline J. Blank ◽  
Rasika R. Deshpande ◽  
Ying Liu ◽  
Carrie Y. Peterson ◽  

2021 ◽  
Tuan Pham ◽  
Vinayakumar Ravi ◽  
Na Liu ◽  
Bin Luo ◽  
Chuan-Wen Fan ◽  

Abstract RhoB protein belongs to the Rho GTPase family, which plays an important role in governing cell signaling and tissue morphology. RhoB expression is known to have implications in pathological processes of diseases. Investigation in the regulation and communication of this protein detected by immunohistochemical staining on the microscope is worth exploring to gain insightful information that may lead to identifying optimal disease treatment options. In particular, the role of RhoB in rectal cancer is not well-discovered. Here, we report that methods of deep learning-based image analysis and the decomposition of multiway arrays discover the predictive factor of RhoB in two cohorts of rectal-cancer patients having survival rates of less and more than 5 years. The analysis results show distinctions between the tensor-decomposition factors of the two cohorts.

2021 ◽  
Vol 12 (1) ◽  
pp. 17-23
Muhammad Fauzi Siregar

Purpose. The objective of this study is to review randomized clinical trials systematically that compare the outcomes of preoperative and postoperative radiotherapy in the management of rectal cancer regarding locoregional recurrance, disease free survival and overall survival.Methods. The relevant randomized clinical trials are searched via online databases such as Pubmed, Ebsco, and Proquest. RCTs publised in English between 2000 until 2020 are selected and reviewed systematically.Result. Locoregional recurrence at 5 years was statistically lower in preoperative radiotherapy group than in postoperative radiotherapy group based on two studies.  Disease free survival at 5-years was statistically higher in preoprative radiotherapy group than the postoperative one based on two studies. Overall survival at 5 years was not statistically significant between two groups for each study.Conclusion. Preoperative radiotherapy is superior to postoperative radiotherapy for controlling locoregional recurrence and disease free survival, but both are equal in overall survival. 

Cancers ◽  
2021 ◽  
Vol 13 (20) ◽  
pp. 5120
Peter Grimm ◽  
Martina Kastrup Loft ◽  
Claus Dam ◽  
Malene Roland Vils Pedersen ◽  
Signe Timm ◽  

Colorectal cancer is the second most common cancer in Europe, and accurate lymph node staging in rectal cancer patients is essential for the selection of their treatment. MRI lymph node staging is complex, and few studies have been published regarding its reproducibility. This study assesses the inter- and intraobserver variability in lymph node size, apparent diffusion coefficient (ADC) measurements, and morphological characterization among inexperienced and experienced radiologists. Four radiologists with different levels of experience in MRI rectal cancer staging analyzed 36 MRI scans of 36 patients with rectal adenocarcinoma. Inter- and intraobserver variation was calculated using interclass correlation coefficients and Cohens-kappa statistics, respectively. Inter- and intraobserver agreement for the length and width measurements was good to excellent, and for that of ADC it was fair to good. Interobserver agreement for the assessment of irregular border was moderate, heterogeneous signal was fair, round shape was fair to moderate, and extramesorectal lymph node location was moderate to almost perfect. Intraobserver agreement for the assessment of irregular border was fair to substantial, heterogeneous signal was fair to moderate, round shape was fair to moderate, and extramesorectal lymph node location was substantial to almost perfect. Our data indicate that subjective variables such as morphological characteristics are less reproducible than numerical variables, regardless of the level of experience of the observers.

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