Comparing functional outcomes between transanal total mesorectal excision (TaTME) and laparoscopic total mesorectal excision (LaTME) for rectal cancer: a systematic review and meta-analysis

2021 ◽  
Author(s):  
Kay T. Choy ◽  
Tze Wei Wilson Yang ◽  
Swetha Prabhakaran ◽  
Alexander Heriot ◽  
Joseph C. Kong ◽  
...  
Keyword(s):  
Systematic Review ◽  
Rectal Cancer ◽  
Total Mesorectal Excision ◽  
Functional Outcomes ◽  
Meta Analysis ◽  
Transanal Total Mesorectal Excision ◽  
Laparoscopic Total Mesorectal Excision ◽  
Mesorectal Excision

scholarly journals Rise and fall of total mesorectal excision with lateral pelvic lymphadenectomy for rectal cancer: an updated systematic review and meta-analysis of 11,366 patients

2021 ◽  
Author(s):  
Gabriele Anania ◽  
Richard Justin Davies ◽  
Alberto Arezzo ◽  
Francesco Bagolini ◽  
Vito D’Andrea ◽  
...  
Keyword(s):  
Systematic Review ◽  
Rectal Cancer ◽  
Total Mesorectal Excision ◽  
Neoadjuvant Therapy ◽  
Functional Outcomes ◽  
Meta Analysis ◽  
Neoadjuvant Chemoradiotherapy ◽  
Disease Free Survival ◽  
Mesorectal Excision ◽  
Timeline Analysis

Abstract The role of lateral lymph node dissection (LLND) during total mesorectal excision (TME) for rectal cancer is still controversial. Many reviews were published on prophylactic LLND in rectal cancer surgery, some biased by heterogeneity of overall associated treatments. The aim of this systematic review and meta-analysis is to perform a timeline analysis of different treatments associated to prophylactic LLND vs no-LLND during TME for rectal cancer. Methods A literature search was performed in PubMed, SCOPUS and WOS for publications up to 1 September 2020. We considered RCTs and CCTs comparing oncologic and functional outcomes of TME with or without LLND in patients with rectal cancer. Results Thirty-four included articles and 29 studies enrolled 11,606 patients. No difference in 5-year local recurrence (in every subgroup analysis including preoperative neoadjuvant chemoradiotherapy), 5-year distant and overall recurrence, 5-year overall survival and 5-year disease-free survival was found between LLND group and non LLND group. The analysis of post-operative functional outcomes reported hindered quality of life (urinary, evacuatory and sexual dysfunction) in LLND patients when compared to non LLND. Conclusion Our publication does not demonstrate that TME with LLND has any oncological advantage when compared to TME alone, showing that with the advent of neoadjuvant therapy, the advantage of LLND is lost. In this review, the most important bias is the heterogeneous characteristics of patients, cancer staging, different neoadjuvant therapy, different radiotherapy techniques and fractionation used in different studies. Higher rate of functional post-operative complications does not support routinely use of LLND.

A systematic review and meta‐analysis on complications of Transanal Total Mesorectal Excision

2021 ◽  
Author(s):  
Yongbo An ◽  
Sapho X. Roodbeen ◽  
Kevin Talboom ◽  
Pieter J. Tanis ◽  
Willem A. Bemelman ◽  
...  
Keyword(s):  
Systematic Review ◽  
Total Mesorectal Excision ◽  
Meta Analysis ◽  
Transanal Total Mesorectal Excision ◽  
Mesorectal Excision

30: Systematic Review and Meta-Analysis of Radiotherapy for T3N0 Rectal Cancer Treated with Total Mesorectal Excision

2021 ◽  
Vol 163 ◽  
pp. S16
Author(s):  
Andrew Bang ◽  
Michael Tjong ◽  
Jesus Fabregas ◽  
Stefania Papatheodorou ◽  
Michael Kucharczyk
Keyword(s):  
Systematic Review ◽  
Rectal Cancer ◽  
Total Mesorectal Excision ◽  
Meta Analysis ◽  
Mesorectal Excision
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