scholarly journals R132H-mutation of isocitrate dehydrogenase-1 is not sufficient for HIF-1α upregulation in adult glioma

2010 ◽  
Vol 121 (2) ◽  
pp. 279-281 ◽  
Author(s):  
Susan C. Williams ◽  
Matthias A. Karajannis ◽  
Luis Chiriboga ◽  
John G. Golfinos ◽  
Andreas von Deimling ◽  
...  
Keyword(s):  
Isocitrate Dehydrogenase ◽  
Isocitrate Dehydrogenase 1 ◽  
R132h Mutation ◽  
Adult Glioma

scholarly journals Extent of BOLD Vascular Dysregulation Is Greater in Diffuse Gliomas without Isocitrate Dehydrogenase 1 R132H Mutation

Radiology ◽  
2018 ◽  
Vol 287 (3) ◽  
pp. 965-972 ◽  
Author(s):  
Zachary K. Englander ◽  
Craig I. Horenstein ◽  
Stephen G. Bowden ◽  
Daniel S. Chow ◽  
Marc L. Otten ◽  
...  
Keyword(s):  
Isocitrate Dehydrogenase ◽  
Isocitrate Dehydrogenase 1 ◽  
Vascular Dysregulation ◽  
Diffuse Gliomas ◽  
R132h Mutation

scholarly journals An R132H Mutation in Isocitrate Dehydrogenase 1 Enhances p21 Expression and Inhibits Phosphorylation of Retinoblastoma Protein in Glioma Cells

2013 ◽  
Vol 53 (10) ◽  
pp. 645-654 ◽  
Author(s):  
Satsuki MIYATA ◽  
Masashi URABE ◽  
Akira GOMI ◽  
Mutsumi NAGAI ◽  
Takashi YAMAGUCHI ◽  
...  
Keyword(s):  
Isocitrate Dehydrogenase ◽  
Glioma Cells ◽  
Retinoblastoma Protein ◽  
Isocitrate Dehydrogenase 1 ◽  
R132h Mutation

Confirmation of R132H mutation of isocitrate dehydrogenase 1 as an independent prognostic factor in anaplastic astrocytoma

2011 ◽  
Vol 122 (5) ◽  
pp. 651-652 ◽  
Author(s):  
Jens Schittenhelm ◽  
Michel Mittelbronn ◽  
Richard Meyermann ◽  
Arthur Melms ◽  
Marcos Tatagiba ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Isocitrate Dehydrogenase ◽  
Anaplastic Astrocytoma ◽  
Independent Prognostic Factor ◽  
Isocitrate Dehydrogenase 1 ◽  
R132h Mutation

Isocitrate dehydrogenase 1 R132H mutation is not detected in angiocentric glioma

2012 ◽  
Vol 16 (4) ◽  
pp. 255-259 ◽  
Author(s):  
Aditya Raghunathan ◽  
Adriana Olar ◽  
Hannes Vogel ◽  
John R. Parker ◽  
Susan C. Coventry ◽  
...  
Keyword(s):  
Isocitrate Dehydrogenase ◽  
Isocitrate Dehydrogenase 1 ◽  
Angiocentric Glioma ◽  
R132h Mutation

scholarly journals Cancer-associated Isocitrate Dehydrogenase 1 (IDH1) R132H Mutation and d-2-Hydroxyglutarate Stimulate Glutamine Metabolism under Hypoxia

2014 ◽  
Vol 289 (34) ◽  
pp. 23318-23328 ◽  
Author(s):  
Zachary J. Reitman ◽  
Christopher G. Duncan ◽  
Ethan Poteet ◽  
Ali Winters ◽  
Liang-Jun Yan ◽  
...  
Keyword(s):  
Isocitrate Dehydrogenase ◽  
Glutamine Metabolism ◽  
Isocitrate Dehydrogenase 1 ◽  
Idh1 R132h ◽  
R132h Mutation

scholarly journals P01.03 * FUNCTIONAL CHARACTERISATION OF THE ISOCITRATE DEHYDROGENASE 1 (IDH 1) R132H MUTATION IN GLIOMAS

2014 ◽  
Vol 16 (suppl 2) ◽  
pp. ii27-ii27
Author(s):  
J. Biedermann ◽  
K. A. El-Ardat ◽  
M. Conde ◽  
R. Wiedemuth ◽  
M. Peitzsch ◽  
...  
Keyword(s):  
Isocitrate Dehydrogenase ◽  
Isocitrate Dehydrogenase 1 ◽  
Functional Characterisation ◽  
R132h Mutation

Structural analysis of oncogenic mutation of isocitrate dehydrogenase 1

2016 ◽  
Vol 12 (7) ◽  
pp. 2276-2287 ◽  
Author(s):  
Vidya Rajendran
Keyword(s):  
Structural Analysis ◽  
Isocitrate Dehydrogenase ◽  
Isocitrate Dehydrogenase 1 ◽  
Oncogenic Mutation

Arginine to histidine mutation at position 132 (R132H) in isocitrate dehydrogenase 1 (IDH1) led to reduced affinity of the respective enzymes for isocitrate and increased affinity for α-ketoglutarate (AKG) and NADPH.

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