Features of anti-aquaporin 4 antibody-seropositive Chinese patients with neuromyelitis optica spectrum optic neuritis

2015 ◽  
Vol 262 (10) ◽  
pp. 2293-2304 ◽  
Author(s):  
Hongyang Li ◽  
Yanling Wang ◽  
Quangang Xu ◽  
Aidi Zhang ◽  
Huanfen Zhou ◽  
...  
Keyword(s):  
Optic Neuritis ◽  
Neuromyelitis Optica ◽  
Aquaporin 4 ◽  
Chinese Patients ◽  
Aquaporin 4 Antibody

Optic neuritis: a 5-year follow-up study of Chinese patients based on aquaporin-4 antibody status and ages

2016 ◽  
Vol 263 (7) ◽  
pp. 1382-1389 ◽  
Author(s):  
Huanfen Zhou ◽  
Shuo Zhao ◽  
Dongfang Yin ◽  
Xiaofei Chen ◽  
Quangang Xu ◽  
...  
Keyword(s):  
Optic Neuritis ◽  
Aquaporin 4 ◽  
Chinese Patients ◽  
Follow Up Study ◽  
Aquaporin 4 Antibody

Prognostic factors and disease course in aquaporin-4 antibody-positive Chinese patients with acute optic neuritis

2017 ◽  
Vol 264 (10) ◽  
pp. 2130-2140 ◽  
Author(s):  
Hao Kang ◽  
Tingjun Chen ◽  
Hongyang Li ◽  
Quangang Xu ◽  
Shanshan Cao ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Optic Neuritis ◽  
Aquaporin 4 ◽  
Chinese Patients ◽  
Disease Course ◽  
Acute Optic Neuritis ◽  
Aquaporin 4 Antibody

scholarly journals The expanded spectrum of neuromyelitis optica: evidences for a new definition

2012 ◽  
Vol 70 (10) ◽  
pp. 807-813 ◽  
Author(s):  
Marco A Lana-Peixoto ◽  
Dagoberto Callegaro
Keyword(s):  
Optic Nerve ◽  
Optic Neuritis ◽  
Neuromyelitis Optica ◽  
Brain Mri ◽  
Transverse Myelitis ◽  
Aquaporin 4 ◽  
Longitudinally Extensive Transverse Myelitis ◽  
Index Event ◽  
Aquaporin 4 Antibody ◽  
Extensive Transverse Myelitis

Neuromyelitis optica (NMO) has been traditionally described as the association of recurrent or bilateral optic neuritis and longitudinally extensive transverse myelitis (LETM). Identification of aquaporin-4 antibody (AQP4-IgG) has deeply changed the concept of NMO. A spectrum of NMO disorders (NMOSD) has been formulated comprising conditions which include both AQP4-IgG seropositivity and one of the index events of the disease (recurrent or bilateral optic neuritis and LETM). Most NMO patients harbor asymptomatic brain MRI lesions, some of them considered as typical of NMO. Some patients with aquaporin-4 autoimmunity present brainstem, hypothalamic or encephalopathy symptoms either preceding an index event or occurring isolatedly with no evidence of optic nerve or spinal involvement. On the opposite way, other patients have optic neuritis or LETM in association with typical lesions of NMO on brain MRI and yet are AQP4-IgG seronegative. An expanded spectrum of NMO disorders is proposed to include these cases.

Distinct clinical characteristics of atypical optic neuritis with seronegative aquaporin-4 antibody among Chinese patients

2017 ◽  
Vol 101 (12) ◽  
pp. 1720-1724 ◽  
Author(s):  
Huanfen Zhou ◽  
Quangang Xu ◽  
Shuo Zhao ◽  
Wei Wang ◽  
Junqing Wang ◽  
...  
Keyword(s):  
Optic Neuritis ◽  
Clinical Characteristics ◽  
Aquaporin 4 ◽  
Chinese Patients ◽  
Aquaporin 4 Antibody

Cortical oscillopsia without nystagmus, an isolated symptom of neuromyelitis optica spectrum disorder with anti-aquaporin 4 antibody

2011 ◽  
Vol 18 (2) ◽  
pp. 244-247 ◽  
Author(s):  
Sung-Min Kim ◽  
Ji-Soo Kim ◽  
Young Eun Heo ◽  
Hye-Ran Yang ◽  
Kyung Seok Park
Keyword(s):  
Spinal Cord ◽  
Neuromyelitis Optica ◽  
Spectrum Disorder ◽  
Aquaporin 4 ◽  
Neuromyelitis Optica Spectrum Disorder ◽  
Ocular Manifestation ◽  
Initial Manifestation ◽  
Ocular Symptoms ◽  
Head Tremor ◽  
Aquaporin 4 Antibody

Neuromyelitis optica (NMO), mainly affecting optic nerve and spinal cord, can also manifest diverse ocular symptoms due to brain abnormalities. We present a cortical oscillopsia without nystagmus or head tremor in a patient with neuromyelitis optica spectrum disorder (NMOSD) with anti-aquaporin 4 antibody. This rare ocular manifestation, which is easily underestimated owing to absence of the typical nystagmus, can be an initial manifestation of NMOSD.

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