Evaluation of radial peripapillary capillary density in patients with Fuchs uveitis syndrome

2019 ◽  
Vol 257 (12) ◽  
pp. 2735-2742 ◽  
Author(s):  
Yasin Sakir Goker ◽  
Pinar Cakar Ozdal ◽  
Yasemin Ozdamar Erol ◽  
Hasan Kızıltoprak ◽  
Mustafa Salih Karatepe
Keyword(s):  
Capillary Density ◽  
Fuchs Uveitis Syndrome ◽  
Radial Peripapillary Capillary

scholarly journals Radial peripapillary capillary density in superior segmental optic hypoplasia measured with OCT angiography.

2020 ◽  
Author(s):  
Maiko Abe ◽  
Kazuko Omodaka ◽  
Tsutomu Kikawa ◽  
Toru Nakazawa
Keyword(s):  
Visual Field Loss ◽  
Normal Subjects ◽  
Capillary Density ◽  
Operating Characteristics ◽  
Swept Source ◽  
Superior Segmental Optic Hypoplasia ◽  
Swept Source Oct ◽  
Retinal Artery ◽  
Diagnostic Power ◽  
Radial Peripapillary Capillary

Abstract Background: To investigate the diagnostic power of radial peripapillary capillary (RPC) density, measured with optical coherence tomography angiography (OCT-A), in patients with superior segmental optic hypoplasia (SSOH). Methods: Forty subjects with SSOH and 40 age- and axial length-matched control subjects were retrospectively registered for this study. SSOH was defined as intraocular pressure less than 21 mmHg with the presence of two of the following: superior rim thinning, superior entrance of the central retinal artery, scleral halo, and pale optic disc; as well as non-progressive visual field loss. RPC density was measured with swept-source OCT-A (Triton, Topcon) overall, in the quadrants, and in the 12 clock-wise sectors. Changes in RPC density were also compared in SSOH patients and age-matched patients with mild- or moderate-stage of glaucoma. RPC density was compared in pairs of groups with Welch’s t-test. Diagnostic power was assessed with the area under the receiver operating characteristics curve (AUC). Results: Overall cpRNFLT was significantly different in the normal (106.7 ± 9.5 μm) and SSOH (77.2 ± 13.7 μm, p < 0.001) subjects. RPC density overall and in the superior, nasal, and inferior quadrants was significantly lower in the SSOH group (all, p < 0.001), but not in the temporal (p = 0.756) quadrant. The diagnostic power of RPC density was highest in the superior quadrant (AUC = 0.928) and the 1 o’clock sector (0.896). Comparing the SSOH and glaucoma patients showed that there were no significant differences in RPC density either overall (p=0.391) or in the superior quadrant (p = 0.268), while RPC density was significantly higher in the inferior (p = 0.005) and temporal quadrants (p < 0.001) and lower in the nasal quadrant (p = 0.029). Conclusions: Low RPC density was found in the three non-temporal quadrants of the optic nerve head in SSOH patients, in comparison to normal subjects. Regionally, RPC density in SSOH was lower in the nasal quadrant and higher in the inferior and temporal quadrants in comparison to glaucoma patients. Measuring RPC density with OCT-A may help the diagnosis of SSOH and may improve the management of glaucoma.

Measurement of Radial Peripapillary Capillary Density in the Normal Human Retina Using Optical Coherence Tomography Angiography

2017 ◽  
Vol 26 (3) ◽  
pp. 241-246 ◽  
Author(s):  
Tarannum Mansoori ◽  
Jayanthi Sivaswamy ◽  
Jahnavi Sai Gamalapati ◽  
Satish Gooty Agraharam ◽  
Nagalla Balakrishna
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Capillary Density ◽  
Human Retina ◽  
Optical Coherence ◽  
Normal Human ◽  
Radial Peripapillary Capillary

scholarly journals Comparison of postoperative changes in radial peripapillary capillary density between femtosecond laser-assisted cataract surgery and conventional phacoemulsification surgery using optical coherence tomography angiography

2020 ◽  
Author(s):  
Hong Zhang ◽  
Liangzhang Tan ◽  
Fang Tian ◽  
Xue Gong ◽  
Lu Chen ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Femtosecond Laser ◽  
Cataract Surgery ◽  
Optical Coherence Tomography Angiography ◽  
Capillary Density ◽  
Optical Coherence ◽  
Time Points ◽  
Postoperative Changes ◽  
Age Related ◽  
Radial Peripapillary Capillary

Abstract Purpose: To assess differences in post-surgical radial peripapillary capillary (RPC) density changes between femtosecond laser-assisted cataract surgery (FLACS) and conventional phacoemulsification surgery (CPS) using optical coherence tomography angiography (OCTA).Methods: Fifty-two eyes of 52 patients were enrolled in this study. Depending on their preference, patients with age-related cataract underwent FLACS or CPS. Automated peripapillary maps and capillary density calculations were retrospectively evaluated using OCTA before surgery and on day 1 and months 1 and 3 postoperatively.Results: The whole-image and peripapillary RPC densities were lower at day 1 and months 1 and 3 postoperatively than before surgery in the FLACS group (all P < 0.05). However, there was no change in the whole-image and peripapillary RPC densities before and after surgery, across different time-points, in the CPS group (all P > 0.05). Moreover, comparison of data corresponding to each time-point between the FLACS and CPS groups showed no significant differences in any metrics prior to surgery (all P > 0.05). However, the whole-image and peripapillary RPC densities were significantly different at day 1 and month 1 after the surgery (all P < 0.05). At the 3-month follow-up, we did not observe significant differences (all P > 0.05). Conclusions: Postoperative whole-image and peripapillary RPC densities were lower in the FLACS group than in the CPS across time-points. While the short-term RPC density changes were resolved, to elucidate the long-term implications of FLACS, especially for eyes with glaucoma, diabetic retinopathy, etc., further investigations are required.

scholarly journals Patients with unilateral retinal vein occlusion show reduced radial peripapillary capillary density in their fellow eyes

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Lingling Fan ◽  
Yazhou Zhu ◽  
Xiaomei Sun ◽  
Jinguo Yu ◽  
Hua Yan
Keyword(s):  
Retinal Vein Occlusion ◽  
Capillary Density ◽  
Fiber Layer ◽  
Vein Occlusion ◽  
Rnfl Thickness ◽  
Temporal Quadrant ◽  
Scan Pattern ◽  
Normal Controls ◽  
Radial Peripapillary Capillary ◽  
Fellow Eyes

Abstract Background To evaluate the radial peripapillary capillary (RPC) density in the fellow eyes of unilateral retinal vein occlusion (RVO) patients using optical coherence tomography angiography (OCTA), and further analyze the correlation between RPC density and peripapillary retinal nerve fiber layer (RNFL) thickness. Methods Seventy-eight unilateral RVO patients and 70 normal controls were included in the study. OCTA was conducted with the 4.5 × 4.5-mm scan pattern centered on the optic nerve head, and the RPC density and peripapillary RNFL thickness were quantified. Results The peripapillary RNFL in the RVO fellow eyes was significantly thinner than in normal controls in the average, inferior-hemisphere, inferior quadrant, and temporal quadrant (P < 0.05, respectively). The RPC density in the fellow eyes was also significantly lower in the average, inferior-hemisphere, nasal quadrant, and temporal quadrant ((P < 0.05, respectively). There were no significant differences in RNFL thickness and RPC density between branch RVO fellow eyes and central RVO fellow eyes. Pearson’s correlation analysis showed significant positive correlations between the RPC density and RNFL thickness in all measurements (P < 0.001, respectively). Conclusions The regional RPC density was reduced in the RVO fellow eyes, which might contribute to peripapillary RNFL thinning in the corresponding region, suggesting the influence of systemic risk factors on RVO. OCTA may offer new insights into the pathophysiology of RVO.

scholarly journals Radial peripapillary capillary density in superior segmental optic hypoplasia measured with OCT angiography.

2020 ◽  
Author(s):  
Maiko Abe ◽  
Kazuko Omodaka ◽  
Tsutomu Kikawa ◽  
Toru Nakazawa
Keyword(s):  
Visual Field Loss ◽  
Normal Subjects ◽  
Capillary Density ◽  
Operating Characteristics ◽  
Swept Source ◽  
Superior Segmental Optic Hypoplasia ◽  
Swept Source Oct ◽  
Retinal Artery ◽  
Diagnostic Power ◽  
Radial Peripapillary Capillary

Abstract Background: To investigate the diagnostic power of radial peripapillary capillary (RPC) density, measured with optical coherence tomography angiography (OCT-A), in patients with superior segmental optic hypoplasia (SSOH).Methods: Forty subjects with SSOH and 40 age- and axial length-matched control subjects were retrospectively registered for this study. SSOH was defined as intraocular pressure less than 21 mmHg with the presence of two of the following: superior rim thinning, superior entrance of the central retinal artery, scleral halo, and pale optic disc; as well as non-progressive visual field loss. RPC density was measured with swept-source OCT-A (Triton, Topcon) overall, in the quadrants, and in the 12 clock-wise sectors. Changes in RPC density were also compared in SSOH patients and age-matched patients with mild- or moderate-stage of glaucoma. RPC density was compared in pairs of groups with Welch’s t-test. Diagnostic power was assessed with the area under the receiver operating characteristics curve (AUC). Results: Overall cpRNFLT was significantly different in the normal (106.7 ± 9.5 μm) and SSOH (77.2 ± 13.7 μm, p < 0.001) subjects. RPC density overall and in the superior, nasal, and inferior quadrants was significantly lower in the SSOH group (all, p < 0.001), but not in the temporal (p = 0.756) quadrant. The diagnostic power of RPC density was highest in the superior quadrant (AUC = 0.928) and the 1 o’clock sector (0.896). Comparing the SSOH and glaucoma patients showed that there were no significant differences in RPC density either overall (p=0.391) or in the superior quadrant (p = 0.268), while RPC density was significantly higher in the inferior (p = 0.005) and temporal quadrants (p < 0.001) and lower in the nasal quadrant (p = 0.029).Conclusions: Low RPC density was found in the three non-temporal quadrants of the optic nerve head in SSOH patients, in comparison to normal subjects. Regionally, RPC density in SSOH was lower in the nasal quadrant and higher in the inferior and temporal quadrants in comparison to glaucoma patients. Measuring RPC density with OCT-A may help the diagnosis of SSOH and may improve the management of glaucoma.

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