Measurement of Radial Peripapillary Capillary Density in the Normal Human Retina Using Optical Coherence Tomography Angiography

2017 ◽  
Vol 26 (3) ◽  
pp. 241-246 ◽  
Author(s):  
Tarannum Mansoori ◽  
Jayanthi Sivaswamy ◽  
Jahnavi Sai Gamalapati ◽  
Satish Gooty Agraharam ◽  
Nagalla Balakrishna
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Capillary Density ◽  
Human Retina ◽  
Optical Coherence ◽  
Normal Human ◽  
Radial Peripapillary Capillary

scholarly journals Comparison of postoperative changes in radial peripapillary capillary density between femtosecond laser-assisted cataract surgery and conventional phacoemulsification surgery using optical coherence tomography angiography

2020 ◽  
Author(s):  
Hong Zhang ◽  
Liangzhang Tan ◽  
Fang Tian ◽  
Xue Gong ◽  
Lu Chen ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Femtosecond Laser ◽  
Cataract Surgery ◽  
Optical Coherence Tomography Angiography ◽  
Capillary Density ◽  
Optical Coherence ◽  
Time Points ◽  
Postoperative Changes ◽  
Age Related ◽  
Radial Peripapillary Capillary

Abstract Purpose: To assess differences in post-surgical radial peripapillary capillary (RPC) density changes between femtosecond laser-assisted cataract surgery (FLACS) and conventional phacoemulsification surgery (CPS) using optical coherence tomography angiography (OCTA).Methods: Fifty-two eyes of 52 patients were enrolled in this study. Depending on their preference, patients with age-related cataract underwent FLACS or CPS. Automated peripapillary maps and capillary density calculations were retrospectively evaluated using OCTA before surgery and on day 1 and months 1 and 3 postoperatively.Results: The whole-image and peripapillary RPC densities were lower at day 1 and months 1 and 3 postoperatively than before surgery in the FLACS group (all P < 0.05). However, there was no change in the whole-image and peripapillary RPC densities before and after surgery, across different time-points, in the CPS group (all P > 0.05). Moreover, comparison of data corresponding to each time-point between the FLACS and CPS groups showed no significant differences in any metrics prior to surgery (all P > 0.05). However, the whole-image and peripapillary RPC densities were significantly different at day 1 and month 1 after the surgery (all P < 0.05). At the 3-month follow-up, we did not observe significant differences (all P > 0.05). Conclusions: Postoperative whole-image and peripapillary RPC densities were lower in the FLACS group than in the CPS across time-points. While the short-term RPC density changes were resolved, to elucidate the long-term implications of FLACS, especially for eyes with glaucoma, diabetic retinopathy, etc., further investigations are required.

scholarly journals Retinal microvasculature alterations in myopic anisometropia on optical coherence tomography angiography

2020 ◽  
Author(s):  
Xiaorong Li ◽  
liangzhang Tan ◽  
lu Chen ◽  
shaochong Bu ◽  
yuanfeng jiang ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Early Stage ◽  
Capillary Density ◽  
Vessel Density ◽  
Foveal Avascular Zone ◽  
Optical Coherence ◽  
Retinal Microvasculature ◽  
Contralateral Eye ◽  
Radial Peripapillary Capillary

Abstract Background: In myopic anisometropia, investigation of alterations in the retinal capillary network may reveal the myopic pathophysiology and facilitate development of improved treatment and prevention strategies. This study aimed to evaluate alterations in retinal vessel density in patients with myopic anisometropia using optical coherence tomography angiography. Methods: Twenty-one patients with myopic anisometropia were divided into longer axial eye and contralateral eye groups, based on their axial length measurement by an IOL Master system. Automated macular and peripapillary maps and vessel density calculations were evaluated using optical coherence tomography angiography, and the findings were compared between groups. Results: The longer axial eye group had higher superficial macular vessel density (47.06±3.03% vs. 43.71±3.20%, respectively; P <0.001) and lower radial peripapillary capillary density (50.11±3.56% vs. 52.34±2.74%, respectively; P =0.013) than did the contralateral eye group. The spherical equivalent negatively correlated with the superficial macular vessel density ( P =0.021) and superficial parafoveal vessel density ( P =0.014). No significant differences were detected in the deep macular vessel density (49.12±6.32% vs. 46.73±5.30%, respectively; P >0.05), choriocapillary perfusion area (1.92±0.18 mm 2 vs.1.90±0.19 mm 2 , respectively; P >0.05), or foveal avascular zone area (0.27±0.07 mm 2 vs. 0.28±0.07 mm 2 , respectively; P >0.05) between groups. Conclusion: The superficial macular vessel density and radial peripapillary capillary density could be used as indicators to monitor myopic anisometropia development during early-stage retinopathy.

Use of ultra-wide field retinal imaging and optical coherence tomography angiography in the diagnosis of incomplete Susac syndrome

2020 ◽  
pp. 112067212096548
Author(s):  
Carmen Alba-Linero ◽  
John Paul Liscombe-Sepúlveda ◽  
Victor Llorenç ◽  
Joan GiraltJosa ◽  
Alfredo Adán
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Capillary Density ◽  
Acute Attack ◽  
Clinical Findings ◽  
Drop Out ◽  
Wide Field ◽  
Optical Coherence ◽  
Cotton Wool Spots ◽  
En Face Oct

Purpose: To describe clinical findings through ultra-wide field (UWF) images and optical coherence tomography angiography (OCT-A), in Susac’s syndrome (SS). Methods: SS patients were retrospectively analyzed in a single center. Clinical features, ultra-wide-field retinographies (UWF-PR), UWF fluorescein angiographies (UWF-FA), and optical coherence tomography angiography & en face (OCT-A/EF) were reviewed. Results: Twelve eyes from six patients with a mean follow-up of 35.66 months ± SD 36.88 were included. UWF-PR showed areas of retinal whitening and cotton-wool spots in all the eyes after acute attack. Segmentary mid peripheral arteriolitis could be observed in five eyes by UWF-FA in acute and convalescent stages. OCT-A revealed capillary density changes in all of the affected eyes. During the acute phase there was a well-preserved superficial capillary network, while deep retinal plexus showed a lower density in the affected areas. OCT-A/EF revealed deep retinal plexus drop-out and surrounding edematous retina in acute attacks, becoming atrophic over time. Conversely, superficial plexus was much less affected. Perifoveal reperfusion was seen in seven eyes after the acute attack. Conclusions: UWF-PR/FA and OCT-A/EF might be helpful to stablish an early diagnosis and to monitor SS progression.

Optical coherence tomography angiography in myopic peripapillary intrachoroidal cavitation complicated by choroidal neovascularization

2020 ◽  
pp. 112067212094401
Author(s):  
Chiara Comune ◽  
Daniela Montorio ◽  
Gilda Cennamo
Keyword(s):  
Optical Coherence Tomography ◽  
Choroidal Neovascularization ◽  
Optical Coherence Tomography Angiography ◽  
Vascular Density ◽  
Optical Coherence ◽  
Pathological Myopia ◽  
Group 2 ◽  
The University ◽  
Radial Peripapillary Capillary ◽  
Intrachoroidal Cavitation

Purpose: To detect the vessel density (VD) of the radial peripapillary capillary (RPC) in eyes affected by pathological myopia with or without a peripapillary intrachoroidal cavitation (PICC) and in eyes with PICC complicated by choroidal neovascularization (CNV), using optical coherence tomography angiography (OCTA). Methods: We prospectively enrolled highly myopic patients from January 2016 to December 2019 at the Eye Clinic of the University of Naples “Federico II.” We divided included patients into three groups: group 1 including patients with PICC complicated by CNV; group 2 including patients with PICC without complications; group 3 including patients with high myopia without PICC and CNV. One-way analysis of variance (ANOVA) followed by Bonferroni post hoc analysis was used to evaluate differences in VD of radial peripapillary capillary (RPC) in papillary whole, peripapillary regions and its sectors among the three groups. Results: We enrolled 12 highly myopic eyes with PICC complicated by CNV, 21 highly myopic eyes with PICC without CNV and 23 highly myopic eyes without PICC. The myopic eyes with PICC revealed a statistically significant reduction in VD of the RPC comparing to the other groups ( p < 0.001), especially in eyes affected by myopic PICC complicated by CNV ( p < 0.001). These results were similar analyzing the VD in different sectors of the peripapillary region among the three groups ( p < 0.001). Conclusion: OCTA detects the changes in peripapillary vascular density of highly myopic eyes. We demonstrated that the RPC vasculature is significantly influenced by the presence of PICC, especially in myopic eyes developing a CNV.

scholarly journals Evaluation of flow of chorioretinal capillaries in healthy black and white subjects using optical coherence tomography angiography

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Nathalie Massamba ◽  
Anna G. Mackin ◽  
Lindsay Y. Chun ◽  
Sarah Rodriguez ◽  
Rose C. Dimitroyannis ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Racial Differences ◽  
Optical Coherence Tomography Angiography ◽  
Capillary Density ◽  
Foveal Avascular Zone ◽  
Optical Coherence ◽  
Flow Area ◽  
Black And White ◽  
Significant Difference ◽  
Retinal Capillary

AbstractThis study compared macular capillary parameters between healthy black and white subjects using optical coherence tomography angiography (OCTA). We measured vessel density (VD) of superficial (SCP), intermediate (ICP), and deep (DCP) capillary plexuses and choriocapillaris blood flow area (BFA) of the fovea, parafovea and total 3 mm-diameter circular area centered on the fovea, as well as the foveal avascular zone (FAZ) parameters, controlling for axial length. Black subjects had lower foveal and parafoveal VD in the SCP (p = 0.043 and p = 0.014) and the ICP (p = 0.014 and p = 0.002). In the DCP, black subjects had a trend toward lower foveal and parafoveal VD. Black subjects had decreased choriocapillaris BFA in the total 3 mm area (p = 0.011) and the parafovea (p = 0.033), larger FAZ area (p = 0.006) and perimeter (p = 0.014), and a higher capillary density in a 300 μm wide region around the FAZ (FD-300) (p = 0.001). There was no significant difference in FAZ acircularity index. To our knowledge, this is the first report analyzing the three distinct retinal capillary plexuses and identifying differing baseline VD, choriocapillaris and FAZ parameters in healthy young black compared to white subjects. Larger studies are needed to validate these findings and better understand racial differences in vulnerability to ocular diseases.

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