Radial peripapillary capillary density in superior segmental optic hypoplasia measured with OCT angiography

Abstract Background: To investigate the diagnostic power of radial peripapillary capillary (RPC) density, measured with optical coherence tomography angiography (OCT-A), in patients with superior segmental optic hypoplasia (SSOH). Methods: Forty subjects with SSOH and 40 age- and axial length-matched control subjects were retrospectively registered for this study. SSOH was defined as intraocular pressure less than 21 mmHg with the presence of two of the following: superior rim thinning, superior entrance of the central retinal artery, scleral halo, and pale optic disc; as well as non-progressive visual field loss. RPC density was measured with swept-source OCT-A (Triton, Topcon) overall, in the quadrants, and in the 12 clock-wise sectors. Changes in RPC density were also compared in SSOH patients and age-matched patients with mild- or moderate-stage of glaucoma. RPC density was compared in pairs of groups with Welch’s t-test. Diagnostic power was assessed with the area under the receiver operating characteristics curve (AUC). Results: Overall cpRNFLT was significantly different in the normal (106.7 ± 9.5 μm) and SSOH (77.2 ± 13.7 μm, p < 0.001) subjects. RPC density overall and in the superior, nasal, and inferior quadrants was significantly lower in the SSOH group (all, p < 0.001), but not in the temporal (p = 0.756) quadrant. The diagnostic power of RPC density was highest in the superior quadrant (AUC = 0.928) and the 1 o’clock sector (0.896). Comparing the SSOH and glaucoma patients showed that there were no significant differences in RPC density either overall (p=0.391) or in the superior quadrant (p = 0.268), while RPC density was significantly higher in the inferior (p = 0.005) and temporal quadrants (p < 0.001) and lower in the nasal quadrant (p = 0.029). Conclusions: Low RPC density was found in the three non-temporal quadrants of the optic nerve head in SSOH patients, in comparison to normal subjects. Regionally, RPC density in SSOH was lower in the nasal quadrant and higher in the inferior and temporal quadrants in comparison to glaucoma patients. Measuring RPC density with OCT-A may help the diagnosis of SSOH and may improve the management of glaucoma.

Download Full-text

Radial peripapillary capillary density in superior segmental optic hypoplasia measured with OCT angiography.

10.21203/rs.2.17299/v4 ◽

2020 ◽

Author(s):

Maiko Abe ◽

Kazuko Omodaka ◽

Tsutomu Kikawa ◽

Toru Nakazawa

Keyword(s):

Visual Field Loss ◽

Normal Subjects ◽

Capillary Density ◽

Operating Characteristics ◽

Swept Source ◽

Superior Segmental Optic Hypoplasia ◽

Swept Source Oct ◽

Retinal Artery ◽

Diagnostic Power ◽

Radial Peripapillary Capillary

Abstract Background: To investigate the diagnostic power of radial peripapillary capillary (RPC) density, measured with optical coherence tomography angiography (OCT-A), in patients with superior segmental optic hypoplasia (SSOH).Methods: Forty subjects with SSOH and 40 age- and axial length-matched control subjects were retrospectively registered for this study. SSOH was defined as intraocular pressure less than 21 mmHg with the presence of two of the following: superior rim thinning, superior entrance of the central retinal artery, scleral halo, and pale optic disc; as well as non-progressive visual field loss. RPC density was measured with swept-source OCT-A (Triton, Topcon) overall, in the quadrants, and in the 12 clock-wise sectors. Changes in RPC density were also compared in SSOH patients and age-matched patients with mild- or moderate-stage of glaucoma. RPC density was compared in pairs of groups with Welch’s t-test. Diagnostic power was assessed with the area under the receiver operating characteristics curve (AUC). Results: Overall cpRNFLT was significantly different in the normal (106.7 ± 9.5 μm) and SSOH (77.2 ± 13.7 μm, p < 0.001) subjects. RPC density overall and in the superior, nasal, and inferior quadrants was significantly lower in the SSOH group (all, p < 0.001), but not in the temporal (p = 0.756) quadrant. The diagnostic power of RPC density was highest in the superior quadrant (AUC = 0.928) and the 1 o’clock sector (0.896). Comparing the SSOH and glaucoma patients showed that there were no significant differences in RPC density either overall (p=0.391) or in the superior quadrant (p = 0.268), while RPC density was significantly higher in the inferior (p = 0.005) and temporal quadrants (p < 0.001) and lower in the nasal quadrant (p = 0.029).Conclusions: Low RPC density was found in the three non-temporal quadrants of the optic nerve head in SSOH patients, in comparison to normal subjects. Regionally, RPC density in SSOH was lower in the nasal quadrant and higher in the inferior and temporal quadrants in comparison to glaucoma patients. Measuring RPC density with OCT-A may help the diagnosis of SSOH and may improve the management of glaucoma.

Download Full-text

Radial peripapillary capillary density in superior segmental optic hypoplasia measured with OCT angiography.

10.21203/rs.2.17299/v1 ◽

2019 ◽

Author(s):

Maiko Abe ◽

Kazuko Omodaka ◽

Tsutomu Kikawa ◽

Toru Nakazawa

Keyword(s):

Visual Field Loss ◽

Capillary Density ◽

Operating Characteristics ◽

Swept Source ◽

Receiver Operating Characteristics Curve ◽

Superior Segmental Optic Hypoplasia ◽

Swept Source Oct ◽

Retinal Artery ◽

Diagnostic Power ◽

Radial Peripapillary Capillary

Abstract Background: To investigate the diagnostic power of radial peripapillary capillary (RPC) density, measured with optical coherence tomography angiography (OCT-A), in patients with superior segmental optic hypoplasia (SSOH), a disease which is important to differentiate from glaucoma. Methods: Forty subjects with SSOH and 40 age- and axial length-matched control subjects were retrospectively registered for this study. SSOH was defined as intraocular pressure (IOP) less than 21 mmHg with the presence of two of the following: superior rim thinning, superior entrance of the central retinal artery, scleral halo, and pale optic disc; as well as non-progressive visual field loss. RPC density was measured with swept-source OCT-A (Triton, Topcon) in the overall, quadrants, and 12 clock-wise sectors. RPC density was compared in normal and SSOH subjects with Welch’s t-test. Diagnostic power was assessed with the area under the receiver operating characteristics curve. Results: Overall cpRNFLT was significantly different in the normal (106.7 ± 9.5 μm) and SSOH (77.2 ± 13.7 μm, p < 0.001) subjects. RPC density in the overall area (p < 0.001) and superior (p < 0.001), nasal (p < 0.001), and inferior (p < 0.001) quadrants was significantly lower in the SSOH group, but not in the temporal (p = 0.756) quadrant. The diagnostic power of RPC density was highest in the superior quadrant (AUC = 0.928) and the 1 o’clock sector (0.896). Conclusions: Low RPC density was found in the three non-temporal quadrants of the optic nerve head. Measuring RPC density with OCT-A may help the diagnosis of SSOH and may improve the management of glaucoma.

Download Full-text

Radial peripapillary capillary density in superior segmental optic hypoplasia measured with OCT angiography.

10.21203/rs.2.17299/v3 ◽

2020 ◽

Author(s):

Maiko Abe ◽

Kazuko Omodaka ◽

Tsutomu Kikawa ◽

Toru Nakazawa

Keyword(s):

Visual Field Loss ◽

Normal Subjects ◽

Capillary Density ◽

Operating Characteristics ◽

Swept Source ◽

Superior Segmental Optic Hypoplasia ◽

Swept Source Oct ◽

Retinal Artery ◽

Diagnostic Power ◽

Radial Peripapillary Capillary

Abstract Background: To investigate the diagnostic power of radial peripapillary capillary (RPC) density, measured with optical coherence tomography angiography (OCT-A), in patients with superior segmental optic hypoplasia (SSOH). Methods: Forty subjects with SSOH and 40 age- and axial length-matched control subjects were retrospectively registered for this study. SSOH was defined as intraocular pressure less than 21 mmHg with the presence of two of the following: superior rim thinning, superior entrance of the central retinal artery, scleral halo, and pale optic disc; as well as non-progressive visual field loss. RPC density was measured with swept-source OCT-A (Triton, Topcon) overall, in the quadrants, and in the 12 clock-wise sectors. Changes in RPC density were also compared in SSOH patients and age-matched patients with mild- or moderate-stage of glaucoma. RPC density was compared in pairs of groups with Welch’s t-test. Diagnostic power was assessed with the area under the receiver operating characteristics curve (AUC). Results: Overall cpRNFLT was significantly different in the normal (106.7 ± 9.5 μm) and SSOH (77.2 ± 13.7 μm, p < 0.001) subjects. RPC density overall and in the superior, nasal, and inferior quadrants was significantly lower in the SSOH group (all, p < 0.001), but not in the temporal (p = 0.756) quadrant. The diagnostic power of RPC density was highest in the superior quadrant (AUC = 0.928) and the 1 o’clock sector (0.896). Comparing the SSOH and glaucoma patients showed that there were no significant differences in RPC density either overall (p=0.391) or in the superior quadrant (p = 0.268), while RPC density was significantly higher in the inferior (p = 0.005) and temporal quadrants (p < 0.001) and lower in the nasal quadrant (p = 0.029). Conclusions: Low RPC density was found in the three non-temporal quadrants of the optic nerve head in SSOH patients, in comparison to normal subjects. Regionally, RPC density in SSOH was lower in the nasal quadrant and higher in the inferior and temporal quadrants in comparison to glaucoma patients. Measuring RPC density with OCT-A may help the diagnosis of SSOH and may improve the management of glaucoma.

Download Full-text

Parafoveal OCT Angiography Features in Diabetic Patients without Clinical Diabetic Retinopathy: A Qualitative and Quantitative Analysis

Journal of Ophthalmology ◽

10.1155/2017/8676091 ◽

2017 ◽

Vol 2017 ◽

pp. 1-14 ◽

Cited By ~ 16

Author(s):

Mathilde M. Goudot ◽

Anne Sikorav ◽

Oudy Semoun ◽

Alexandra Miere ◽

Camille Jung ◽

...

Keyword(s):

Diabetic Retinopathy ◽

Quantitative Analysis ◽

Capillary Density ◽

Oct Angiography ◽

Foveal Avascular Zone ◽

Diabetic Patients ◽

Cross Sectional ◽

The Mean ◽

Fundus Photographs ◽

And Gender

Purpose. To evaluate the capacity of OCT angiography (OCTA) for detecting infraclinical lesions in parafoveal capillaries in diabetic patients without diabetic retinopathy (DR). Methods. This prospective observational cross-sectional case-control study analyzed the superficial and deep capillary plexuses (SCP and DCP) on macular OCTA scans (3 × 3 mm) centered on the fovea. We compared 22 diabetic patients (34 eyes included) without DR diagnosis on color fundus photographs, with 22 age- and gender-matched nondiabetic controls (40 eyes included). Qualitative analysis concerned morphological ischemic capillary alterations. Quantitative analysis measured foveal avascular zone (FAZ) size, parafoveal capillary density, and enlargement coefficient of FAZ between SCP and DCP. Results. Neither the qualitative nor quantitative parameters were significantly different between both groups. No microaneurysms or venous tortuosity was observed in any of the analyzed images. On the SCP, the mean FAZ area was 0.322 ± 0.125 mm2 in diabetic patients and 0.285 ± 0.150 mm2 in controls, P=0.31. On the DCP, the mean FAZ area was 0.444 ± 0.153 mm2 in cases and 0.398 ± 0.138 mm2 in controls, P=0.20. Conclusion. OCTA did not detect infraclinical qualitative or quantitative differences in parafoveal capillaries of diabetic patients without DR in comparison with nondiabetic controls.

Download Full-text

Quantitative assessment of macular microvasculature and radial peripapillary capillary plexus in the fellow eyes of patients with retinal vein occlusion using OCT angiography

Journal Français d Ophtalmologie ◽

10.1016/j.jfo.2020.06.004 ◽

2020 ◽

Vol 43 (9) ◽

pp. 842-850

Author(s):

S. Ozcaliskan ◽

Y. Ozcan

Keyword(s):

Retinal Vein Occlusion ◽

Quantitative Assessment ◽

Oct Angiography ◽

Vein Occlusion ◽

Capillary Plexus ◽

Radial Peripapillary Capillary ◽

Fellow Eyes

Download Full-text

Micro-Heterogeneity of Flow in a Mouse Model of Chronic Cerebral Hypoperfusion Revealed by Longitudinal Doppler Optical Coherence Tomography and Angiography

Journal of Cerebral Blood Flow & Metabolism ◽

10.1038/jcbfm.2015.175 ◽

2015 ◽

Vol 35 (10) ◽

pp. 1552-1560 ◽

Cited By ~ 16

Author(s):

Vivek J Srinivasan ◽

Esther Yu ◽

Harsha Radhakrishnan ◽

Anil Can ◽

Mihail Climov ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Capillary Density ◽

Chronic Cerebral Hypoperfusion ◽

Cerebral Hypoperfusion ◽

Oct Angiography ◽

Imaging Method ◽

Optical Coherence ◽

Doppler Optical Coherence Tomography ◽

Longitudinal Imaging

Although microvascular dysfunction accompanies cognitive decline in aging, vascular dementia, and Alzheimer's disease, tools to study microvasculature longitudinally in vivo are lacking. Here, we use Doppler optical coherence tomography (OCT) and angiography for noninvasive, longitudinal imaging of mice with chronic cerebral hypoperfusion for up to 1 month. In particular, we optimized the OCT angiography method to selectively image red blood cell (RBC)-perfused capillaries, leading to a novel way of assessing capillary supply heterogeneity in vivo. After bilateral common carotid artery stenosis (BCAS), cortical blood flow measured by Doppler OCT dropped to half of baseline throughout the imaged tissue acutely. Microscopic imaging of the capillary bed with OCT angiography further revealed local heterogeneities in cortical flow supply during hypoperfusion. The number of RBC-perfused capillaries decreased, leading to increased oxygen diffusion distances in the days immediately after BCAS. Linear regression showed that RBC-perfused capillary density declined by 0.3% for a drop in flow of 1 mL/100 g per minute, and decreases in RBC-perfused capillary density as high as 25% were observed. Taken together, these results demonstrate the existence of local supply heterogeneity at the capillary level even at nonischemic global flow levels, and demonstrate a novel imaging method to assess this heterogeneity.

Download Full-text