Follicular variant of papillary thyroid carcinoma (FVPTC): histological features, BRAF V600E mutation, and lymph node status

2015 ◽  
Vol 141 (10) ◽  
pp. 1749-1756 ◽  
Author(s):  
Ann E. Walts ◽  
James M. Mirocha ◽  
Shikha Bose
Keyword(s):  
Lymph Node ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Braf V600e Mutation ◽  
Braf V600e ◽  
Lymph Node Status ◽  
Papillary Thyroid ◽  
Follicular Variant ◽  
Histological Features ◽  
Node Status

Diagnostic Accuracy of PET/MR for Evaluating Central Lymph Node Status in Patients with Papillary Thyroid Carcinoma

2017 ◽  
Vol 17 (3) ◽  
pp. 122
Author(s):  
Yoon Hyeong Byeon ◽  
Jung Eun Choi ◽  
Jeong Yeong Park ◽  
Jeong Hyun Song ◽  
Kyeong Jun Yeo ◽  
...  
Keyword(s):  
Lymph Node ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Diagnostic Accuracy ◽  
Lymph Node Status ◽  
Papillary Thyroid ◽  
Central Lymph Node ◽  
Node Status ◽  
Central Lymph

Microscopic regional lymph node status in papillary thyroid carcinoma with and without lymphadenopathy and its relation to outcomes

2007 ◽  
Vol 392 (4) ◽  
pp. 417-422 ◽  
Author(s):  
Nobuyuki Wada ◽  
Nobuyasu Suganuma ◽  
Hirotaka Nakayama ◽  
Katsuhiko Masudo ◽  
Yasushi Rino ◽  
...  
Keyword(s):  
Lymph Node ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Regional Lymph Node ◽  
Lymph Node Status ◽  
Papillary Thyroid ◽  
Node Status

Lymph node status of lateral neck compartment in patients with N1b papillary thyroid carcinoma

2015 ◽  
Vol 136 (3) ◽  
pp. 319-324 ◽  
Author(s):  
Young Min Park ◽  
Soo-Geun Wang ◽  
Dong Hoon Shin ◽  
In-Ju Kim ◽  
Seok-Man Son ◽  
...  
Keyword(s):  
Lymph Node ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Lymph Node Status ◽  
Lateral Neck ◽  
Papillary Thyroid ◽  
Node Status

scholarly journals Prediction of Lymph Node Metastasis in Patients With Papillary Thyroid Carcinoma: A Radiomics Method Based on Preoperative Ultrasound Images

2019 ◽  
Vol 18 ◽  
pp. 153303381983171 ◽  
Author(s):  
Tongtong Liu ◽  
Shichong Zhou ◽  
Jinhua Yu ◽  
Yi Guo ◽  
Yuanyuan Wang ◽  
...  
Keyword(s):  
Lymph Node ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Receiver Operating Characteristic Curve ◽  
Receiver Operating Characteristic ◽  
Operating Characteristic ◽  
Lymph Node Status ◽  
Papillary Thyroid ◽  
Node Status ◽  
Operating Characteristic Curve

Background: Papillary thyroid carcinoma is a type of indolent tumor with a dramatically increasing incidence rate and stably high survival rate. Reducing the overdiagnosis and overtreatment of papillary thyroid carcinoma is clinically emergent and important. A radiomics model is proposed in this article to predict lymph node metastasis, the most important risk factor of papillary thyroid carcinoma, based on noninvasive routine preoperative ultrasound images. Methods: Four hundred fifty ultrasound manually segmented images of patients with papillary thyroid carcinoma with lymph node status obtained from pathology report were enrolled in our retrospective study. A radiomics evaluation of 614 high-throughput features were calculated, including size, shape, margin, boundary, orientation, position, echo pattern, posterior acoustic pattern, and calcification features. Then, combined feature selection strategy was used to select features with the greatest ability to discriminate lymph node status. A support vector machine classifier was employed to build and validate the prediction model. Another independent testing cohort was used to further evaluate the performance of the radiomics model. Results: Among 614 radiomics features, 50 selected features most reflecting echo pattern, posterior acoustic pattern, and calcification showed the superior lymph node status distinguishable performance with area under the receiver operating characteristic curve of 0.753, 0.740, and 0.743 separately when using each type of features predicting the lymph node status. The results of model based on all 50 final features predicting the lymph node status shown an area under the receiver operating characteristic curve of 0.782, and accuracy of 0.712. In the independent testing cohort, the proposed approach showed similar results, with area under the receiver operating characteristic curve of 0.727 and accuracy of 0.710. Conclusion: Papillary thyroid carcinoma with lymph node metastasis usually shows a complex echo pattern, posterior region homogeneity, and macrocalcification or multiple calcification. The radiomics model proposed in this article is a promising method for assessing the risk of papillary thyroid carcinoma metastasis noninvasively.

scholarly journals High Preponderance of BRAF V600E Mutation in Papillary Thyroid Carcinoma Among Filipinos: A Clinicopathologic Study

2019 ◽  
pp. 1-6
Author(s):  
Gerard Anthony M. Espiritu ◽  
Joemari T. Malana ◽  
Arlie Jean Grace V. Dumasis ◽  
Daphne C. Ang
Keyword(s):  
Lymph Node ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Braf Mutation ◽  
Lymph Node Involvement ◽  
Extrathyroidal Extension ◽  
Braf V600e Mutation ◽  
Braf V600e ◽  
Papillary Thyroid ◽  
Node Involvement

Purpose BRAF mutation in papillary thyroid carcinoma (PTC) is associated with an aggressive phenotype, with varying incidence. We evaluated the prevalence of BRAF mutations in PTC among Filipino patients and their correlation with clinicopathologic characteristics. Patients and Methods Clinicopathologic data were retrieved from 64 sequential patients who underwent thyroidectomy from June 2016 to December 2016. BRAF mutation testing was performed using Sanger sequencing. Results Eighteen (28%) of 64 patients were diagnosed with PTC; 12 (70.59%) of 17 harbored a BRAF V600E mutation (no amplification in one patient). Demographics of patients with PTC were as follows: 13 women and five men, with median age of 46 years (range, 25 to 74 years). Fourteen patients had conventional subtype PTC; two, follicular variant; one, oncocytic variant; and one, tall-cell features. Tumor size ranged from 0.8 to 7.0 cm (median, 2.4 cm); extrathyroidal extension was present in seven (38.9%) of 18 patients, multifocality in six (33.33%) of eight, and lymph node involvement in eight (44.4%) of 18. Significant association between presence of a BRAF mutation and presence of extrathyroidal extension or lymph node involvement was not determined due to the limited sample size. Conclusion The high preponderance of BRAF mutation (70.59%) suggests some correlation with the previously reported lower 5-year survival among Filipinos. This warrants further investigation in a larger-cohort prospective study.

Role of BRAF V600E mutation as an indicator of the extent of thyroidectomy and lymph node dissection in conventional papillary thyroid carcinoma

Surgery ◽  
2015 ◽  
Vol 158 (6) ◽  
pp. 1500-1511 ◽  
Author(s):  
Seo Ki Kim ◽  
Jung-Woo Woo ◽  
Jun Ho Lee ◽  
Inhye Park ◽  
Jun-Ho Choe ◽  
...  
Keyword(s):  
Lymph Node ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Lymph Node Dissection ◽  
Braf V600e Mutation ◽  
Braf V600e ◽  
Papillary Thyroid ◽  
Node Dissection

Follicular thyroid carcinoma and follicular variant papillary thyroid carcinoma: Clinical and histological features depending on the initial size

2017 ◽  
Author(s):  
Fernando Garcia Perez ◽  
Guillermo Martinez de Pinillos Gordillo ◽  
Mariana Tome Fernandez-Ladreda ◽  
Eyvee Arturo Cuellar Lloclla ◽  
Jose Alvaro Romero Porcel ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Follicular Thyroid Carcinoma ◽  
Papillary Thyroid ◽  
Follicular Variant ◽  
Initial Size ◽  
Histological Features

Mixed histiocytosis with BRAF (V600E) mutation and papillary thyroid carcinoma

2019 ◽  
Author(s):  
Francoise Archambeaud ◽  
Pauline Vital ◽  
Gilles Russ ◽  
Isabelle Pommepuy ◽  
Julien Haroche ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Braf V600e Mutation ◽  
Braf V600e ◽  
Papillary Thyroid

The role of BRAF V600E mutation in post-surgical 131I therapy in papillary thyroid carcinoma. A study based on SPECT-CT uptake analysis

2021 ◽  
Author(s):  
Maite DOMÍNGUEZ-AYALA ◽  
Pablo MÍNGUEZ-GABIÑA ◽  
Miguel PAJA-FANO ◽  
Amaia BILBAO-GONZÁLEZ ◽  
Amaia EXPÓSITO-RODRÍGUEZ ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Braf V600e Mutation ◽  
Braf V600e ◽  
131I Therapy ◽  
Papillary Thyroid
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