Does long-term medication with a proton pump inhibitor induce a tolerance to H2 receptor antagonist?

2007 ◽  
Vol 42 (4) ◽  
pp. 275-278 ◽  
Author(s):  
Hiroshi Hashimoto ◽  
Tetsuya Kushikata ◽  
Mihoko Kudo ◽  
Kazuyoshi Hirota
Keyword(s):  
Proton Pump Inhibitor ◽  
Receptor Antagonist ◽  
Proton Pump ◽  
H2 Receptor Antagonist ◽  
H2 Receptor

Administration of H2 Receptor Antagonist With Proton Pump Inhibitor Is Effective for Long-term Control of Refractory Reflux Esophagitis

2004 ◽  
Vol 38 (3) ◽  
pp. 297-298 ◽  
Author(s):  
Kyoichi Adachi ◽  
Yoshinori Komazawa ◽  
Takafumi Mihara ◽  
Hirofumi Fujishiro ◽  
Shunji Ishihara ◽  
...  
Keyword(s):  
Proton Pump Inhibitor ◽  
Receptor Antagonist ◽  
Proton Pump ◽  
Reflux Esophagitis ◽  
H2 Receptor Antagonist ◽  
H2 Receptor

scholarly journals Reducing dyspeptic symptoms in children: proton pump inhibitor vs. H2 receptor antagonist

2014 ◽  
Vol 54 (4) ◽  
pp. 198
Author(s):  
Tien Budi Febriani ◽  
Titis Widowati ◽  
Mohammad Juffrie
Keyword(s):  
Proton Pump Inhibitor ◽  
Receptor Antagonist ◽  
Proton Pump ◽  
Rome Iii Criteria ◽  
Receptor Antagonists ◽  
H2 Receptor Antagonist ◽  
Double Blind ◽  
H2 Receptor ◽  
Dyspeptic Symptoms ◽  
Rome Iii

Background Dyspepsia is known as a leading cause of uppergastrointestinal tract morbidity. If left untreated, dyspepsia maybecome chronic. Dyspeptic symptoms manifest as epigastricpain, heartburn, nausea, hematemesis, or melena. Experimentalstudies have shown that omeprazole is more effective at reducingheartburn than ranitidine in adults. However, there have beenfew studies comparing the effects of proton pump inhibitorsto Hz receptor antagonists for reducing dyspeptic symptoms inchildren.Objective To compare the effect of omeprazole with ranitidinefor reducing dyspeptic symptoms .Methods We performed a double-blind randomized controlledtrial (RCT) at Sardjito Hospital and three community h ealthcenters in the Sleman District from June to November 2012.We recruited children aged 3-18 years with dyspepsia. Subjectswere allocated into two groups using block randomization:the proton pump inhibitor (omeprazole) and the Hz receptorantagonist (ranitidine) groups. According to the groups, eitheromeprazole (0.4-0 .8 mg/kg/dose) or ranitidine (2-4 mg/kg/dose) ,respectively, were taken twice daily for 5 days. Dyspepsia wasclinically diagnosed using the new Rome III criteria. Both groupswere monitored for 5 days to assess for a reduction of dyspepticsymptoms.Results Significantly more subjects in the omeprazole grouprecovered from dyspeptic symptoms than in the ranitidine group(RR= 4.87; 95%CI 1.5 to 15.3; P=0.005).Conclusion Omeprazole was 4.87 (95% CI 1.5 to 15.3) timesbetter than ranitidine in reducing dyspeptic symptoms on childrenaged 3-18 years with dyspepsia.

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