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Author(s):  
Gholam Reza Ghayour Razmgah ◽  
Seyed Mousal-Reza Hosseini ◽  
Homa Hajimehdipoor ◽  
Mehdi Saberi Firoozi ◽  
Haniye Kashafroodi ◽  
...  

The most common functional gastrointestinal problem in the world is functional constipation. "Ayarij-e-Faiqra (AF)" is a polyherbal formula that has been recommended by Persian Medicine as an efficent purgative agent . The purpose of this study was to evaluate the effect of AF on functional constipation using a double-blind, placebo-controlled clinical trial. According to the Rome III classification, 79 adults with functional constipation were included in this trial. The diagnostic criteria were according to the Rome III classification. Patients with constipation symptoms who referred to the traditional medicine clinic of Shahid Beheshti University of Medical Sciences from April 2014 to September 2016 were randomly allocated to the AF and placebo groups. The AF and placebo groups received AF and placebo for three months, respectively and followed up for another three months. During the study, the treatment efficacy was assessed by a questionnaire. AF treatment significantly decreased most of the symptoms by 84% at the end of the first month (p < 0.05) and by 90% at the end of the third month in comparison to placbo group (p < 0.001). However, three months after the end of the intervention, the frequency of constipation symptoms in both groups was not statistically significant. Based on the satisfaction questionnaire, the treatment satisfaction score during the intervention was increased to 9 in the AF group, but no significant difference was found between the two groups three months after the intervention (p > 0.005). Although AF could be beneficial for treating functional constipation without significant side effects, changing patients’ lifestyles has  great importance in this process.


2022 ◽  
Vol 9 ◽  
Author(s):  
Leilani Muhardi ◽  
Marion M. Aw ◽  
Mohammed Hasosah ◽  
Ruey Terng Ng ◽  
Sze Yee Chong ◽  
...  

Regurgitation, colic, and constipation are frequently reported Functional Gastrointestinal Disorders (FGIDs) in the first few years of life. In 2016, the diagnostic criteria for FGIDs were changed from ROME III to ROME IV. This review assesses the prevalence of the most frequent FGIDs (colic, regurgitation and constipation) among children aged 0–5 years after the introduction of the later criteria. Articles published from January 1, 2016 to May 1, 2021 were retrieved from PubMed and Google Scholar using relevant keywords. A total of 12 articles were further analyzed based on the inclusion and exclusion criteria. This review consists of two studies (17%) from the Middle East, three (25%) from Asia, two (17%) from the USA, three (25%) from Europe, and one (8%) from Africa. Three studies (25%) were based on data obtained from healthcare professionals, while the rest were parent or caregiver reports. About half of the retrieved studies used the ROME IV criteria. Among infants aged 0–6 months, the reported prevalence of colic ranged between 10–15%, whilst that of regurgitation was 33.9%, and constipation was 1.5%. Among infants aged 0–12 months, the reported prevalence of regurgitation and constipation were 3.4–25.9% and 1.3–17.7%, respectively. The reported prevalence of constipation was 1.3–26% among children aged 13–48 months and 13% among children aged 4–18 years. Despite the large variations due to differences in diagnostic criteria, study respondents and age group, the prevalence of infantile colic was higher, while that for infantile regurgitation and constipation were similar using the ROME IV or III criteria.


Nutrients ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 4147
Author(s):  
Anouk Reuzé ◽  
Rosalie Delvert ◽  
Laëtitia Perrin ◽  
Robert Benamouzig ◽  
Jean-Marc Sabaté ◽  
...  

Self-management of irritable bowel syndrome (IBS) is increasingly focusing on exclusion diets. In particular; patients are showing a significant interest in the gluten-free diet for the treatment of IBS. However; the lack of scientific evidence prevents the establishment of clear dietary guidelines and attention is needed as dietary restriction can lead to potentially adverse effects. This cross-sectional study aims to explore the practice of gluten avoidance in participants identified with IBS in a large cohort of non-celiac French adults. The population included 15,103 participants of the NutriNet-Santé study who completed a functional gastrointestinal disorder questionnaire based on the Rome III criteria to identify IBS in 2013 and a food avoidance questionnaire in 2016. Data on diet and anthropometric and sociodemographic characteristics were collected. Multivariate logistic regression models were used to compare the avoidance of gluten between IBS and non-IBS participants. Participants were mainly women (73.4%) and the mean age in this population was 55.8 ± 13.2 years. Among these individuals, 804 (5.4%) participants were identified as IBS cases. Among them, the prevalence of gluten avoidance was estimated at 14.8%, of which 3.0% reported total avoidance; versus 8.8% and 1.6% in non-IBS participants. After adjustments; gluten avoidance was higher in IBS participants compared to their non-IBS counterparts: (OR = 1.86; 95%CI = 1.21, 2.85) for total and (OR = 1.71; 95%CI = 1.36, 2.14) for partial avoidance. Participants identified with IBS were more associated with gluten avoidance than non-IBS participants. Further studies are needed to explore the long-term consequences of dietary interventions and to provide consistent dietary guidance connected to patient perception.


Author(s):  
Khaldoon Thanoon Al-Abachi

Abstract Background Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder. Celiac disease (CD), a treatable autoimmune enteropathy, with varied presentations, may simulate clinically symptoms of IBS. The aim of the present study is to screen for CD in patients with IBS diagnosed based on the Rome III criteria. Patients and Methods A cross-sectional study was conducted at a secondary care gastrointestinal unit in Al-Salam General Hospital in Mosul city, Iraq, from November 2015 to October 2016. All patients fulfilling the Rome III criteria for IBS were screened for CD using antitissue transglutaminase IgA antibodies (anti-tTG). Patients who tested positive were subjected to endoscopic duodenal biopsy to confirm the diagnosis of CD. Results A total of 100 patients were included in the present study (58 female and 42 male), the mean age of the participants was 40.8 years old (standard deviation [SD] ± 11.57). Ten patients (10/100, 10%) tested positive for anti-tTG antibodies. Five of the seropositive patients (5/10, 50%) showed positive biopsy results according to the Marsh classification, 3 of whom having diarrhea, and 2 with constipation. Conclusion Positive serology and biopsy results suggestive of CD are common among patients with IBS. Screening patients with IBS for CD is justified.


2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Sara Tavassoli ◽  
Kambiz Eftekhari ◽  
Mehrdad Karimi ◽  
Ali Ghobadi ◽  
Mohsen Shati ◽  
...  

Background. Functional constipation (FC) is a health concern that is prevalent in the pediatric population. It lowers the quality of life and increases the probability of comorbidities. As a complementary modality, herbal medicine has been considered useful in a variety of conditions. Persian medicine (PM) resources mention the Viola flower as an effective herb in treating constipation. The purpose of the current trial was to evaluate the efficacy of Viola flower syrup (VFS) compared with polyethylene glycol (PEG) in children with functional constipation. Methods. This randomized, active-controlled, single-center trial was conducted on 140 children aged between 4 and 10 years with confirmed FC according to Rome III criteria. Participants were randomly assigned to receive either VFS or PEG for four weeks. Independent t-test and general linear model (GLM) repeated measures analysis of variance were used to determine the intergroup difference, and paired sample t-test was used to evaluate the intragroup difference. Results. After four weeks of intervention, 133 individuals (66 in VFS and 67 in the PEG group) were analyzed. Results of both groups demonstrated significant improvement in all measured criteria at the end of the study compared to baseline ( P < 0.001 ). No significant difference was observed between the two groups at baseline or at the end of the study ( P > 0.05 ), except for fecal retention at baseline ( P = 0.028 ). Participants in the PEG group experienced more side effects compared to the VFS group. Conclusion. The findings of this investigation indicated that VFS is an effective and relatively safe medication to be used in the treatment of pediatric FC.


Life ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 772
Author(s):  
Judith M. Lionarons ◽  
Imelda J. M. de Groot ◽  
Johanna M. Fock ◽  
Sylvia Klinkenberg ◽  
Desiree M. J. Vrijens ◽  
...  

Introduction: Lower urinary tract symptoms (LUTS) and gastrointestinal (GI) problems are common in Duchenne muscular dystrophy (DMD), but not systematically assessed in regular care. We aimed to determine the prevalence of bladder and bowel dysfunction (BBD) in DMD patients compared with healthy controls (HC). Methods: The Childhood Bladder and Bowel Dysfunction Questionnaire (CBBDQ) based on the International Rome III criteria and the International Children’s Continence Society was filled out by 57 DMD patients and 56 HC. Additionally, possible associations of BBD with, for example, medication use or quality of life were evaluated in an additional questionnaire developed by experts. Results: In 74% of patients versus 56% of HC ≥1 LUTS (n.s.) were reported, 68% of patients versus 39% of HC reported ≥1 bowel symptom (p = 0.002) and 53% of patients versus 30% of HC reported combined LUTS and bowel symptoms (p = 0.019). A negative impact of BBD on daily life functioning was reported by 42% of patients. Conclusions: These data underscore that standard screening for BBD is needed and that the CBBDQ could be of added value to optimize DMD care.


2021 ◽  
Vol 502 (1) ◽  
Author(s):  
Võ Duy Thông ◽  
Nguyễn Ngọc Phúc
Keyword(s):  

Đặt vấn đề: Hội chứng ruột kích thích (IBS) là một bệnh lý với các triệu chứng đường tiêu hóa như đau bụng, chướng bụng, đầy hơi, ảnh hưởng nhiều đến chất lượng cuộc sống (CLCS) của bệnh nhân (BN). Mục tiêu: Khảo sát hiệu quả điều trị của thuốc sulpiride trong cải thiện chất lượng cuộc sống ở bệnh nhận hội chứng ruột kích thích. Đối tượng và phương pháp nghiên cứu: Nghiên cứu cắt ngang mô tả thực hiện trên những BN IBS được bác sĩ chẩn đoán bằng tiêu chuẩn ROME III tại phòng khám Tiêu hoá, bệnh viện Đại học Y Dược TP. Hồ Chí Minh từ 01/06/2018 – 01/02/2019, có hoặc không sử dụng sulpiride. Thu thập số liệu về đặc điểm nền của bệnh nhân, điểm CLCS được thu thập dựa trên bộ câu hỏi IBS-QoL phiên bản tiếng Việt đã được dịch thuật và thẩm định cho toàn bộ đối tượng tham gia nghiên cứu tại thời điểm ban đầu và sau 8 tuần theo dõi. Kết quả: Sau 8 tuần theo dõi, 246 BN hoàn thành nghiên cứu, trong đó 120 BN nhóm điều trị có sulpiride và 126 BN nhóm điều trị không có sulpiride, tỷ lệ nữ/nam là 1,4/1. Sau 8 tuần theo dõi, kết quả điểm CLCS tổng thể và các điểm CLCS ở các khía cạnh đặc điểm khó chịu, lo lắng sức khỏe, phản ứng xã hội, mối quan hệ cao hơn có ý nghĩa thống kê so với nhóm không sulpiride (p < 0,001). Khi đánh giá độ thay đổi điểm CLCS, độ thay đổi điểm CLCS tổng thể và các khía cạnh khó chịu, cản trở hoạt động, hình thể, lo lắng sức khỏe, phản ứng xã hội, mối quan hệ ở nhóm có sulpiride cũng cao hơn có ý nghĩa thống kê so với nhóm không dùng sulpiride, ulpuride (p < 0,05). Kết luận: Sử dụng thuốc sulpiride điều trị BN IBS giúp cải thiện CLCS tổng thể, thay đổi ở các đặc điểm khó chịu, cản trở hoạt động, hình thể, lo lắng sức khỏe, phản ứng xã hội, mối quan hệ.


Gerontology ◽  
2021 ◽  
pp. 1-10
Author(s):  
Sandra Arco ◽  
Esther Saldaña ◽  
Mateu Serra-Prat ◽  
Elisabet Palomera ◽  
Yolanda Ribas ◽  
...  

<b><i>Introduction:</i></b> Functional constipation (FC) is very prevalent in older adults, especially in women, but its relationship with frailty is not fully understood. The aims were to assess FC prevalence, clinical symptoms and subtypes, association with frailty, and impact on quality of life (QoL) in older people. <b><i>Methods:</i></b> This epidemiological study included 384 individuals aged over 70 years recruited from the community, a hospital, and a nursing home and stratified into robust, pre-frail, and frail groups (Fried criteria). The following criteria were evaluated: frailty, FC (Rome III criteria), stool consistency (Bristol Stool Chart), comorbidities (Charlson), dependency (Barthel), QoL (EQ5D), and clinical and sociodemographic data. Defined by symptom aggregation were 2 main clinical subtypes as follows: slow colonic transit time (CTT) and functional defecation disorder (FDD). <b><i>Results:</i></b> Mean age was 79.11 ± 6.43 years. Overall FC prevalence was 26.8%, higher in women (32.4% women vs. 21.8% men; <i>p</i> = 0.019) and highest in frail patients (41.7% frail vs. 33.9% pre-frail vs. 24.2% robust; <i>p</i> &#x3c; 0.001). Straining and hard stools (Bristol 1–2) were the most prevalent symptoms (89.3 and 75.7%, respectively). Frailty and benzodiazepine intake were independently associated with FC. Patients with FC obtained poorer QoL scores in the EQ5D (perceived health 66.09 ± 17.8 FC patients vs. 56.4 ± 19.03 non-FC patients; <i>p</i> &#x3c; 0.05). The FDD subtype became significantly more prevalent as frailty increased (6.5, 25.8, and 67.7% for robust, pre-frail, and frail patients, respectively); the slow CTT subtype was significantly more frequent in robust patients (38.5% robust vs. 30.5% pre-frail vs. 23.1% frail), <i>p</i> = 0.002. <b><i>Discussion/Conclusion:</i></b> FC prevalence in older adults was high, especially in women, and was associated with frailty and poor QoL. Clinical subtypes as related to frailty phenotypes reflect specific pathophysiological aspects and should lead to more specific diagnoses and improved treatment.


2021 ◽  
Vol 51 (2) ◽  
Author(s):  
Tatiana Noemí Uehara ◽  
Harumi Hashimoto ◽  
Federico Bazán ◽  
Adriana Tévez ◽  
Gladys Bravo ◽  
...  

Background and aims. The appropriate diagnosis of irritable bowel syndrome is critical due to its association with impaired quality of life and high health care costs. We aim to explore the proportion of subjects with irritable bowel syndrome by the Rome IV criteria at a tertiary care hospital and compare them with previous diagnostic criteria. Material and methods. We conducted a cross-sectional descriptive study in a tertiary care hospital located in Buenos Aires. There were included to the consecutive adult patients who consulted for abdominal disorders and in whom an organic pathology had been excluded. Subjects completed a gastrointestinal symptom questionnaire and the proportion of patients with IBS, according to Roma IV criteria, was compare with the proportion of those who met the previous criteria (Manning, Rome I, II and III). Results. Of 178 patients included, 58% met the diagnosis criteria for IBS using the Rome IV criteria. Of these, 98% were also Rome III positive, 76.7% IBS Rome II positive, 93% IBS Rome I positive and 99% IBS Manning positive. The agreement was very good with Rome III (kappa = 0.87), good with Rome I (kappa = 0.76) and good, but lower with Rome II (kappa = 0.73) and Manning (kappa = 0.66). Conclusions. Good diagnostic agreement was established between Rome IV and the previous IBS criteria, except with Rome II and Manning, which were lower.


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