Recreational drug abuse in patients hospitalized for diabetic ketosis or diabetic ketoacidosis

Abstract Background: Sick euthyroid syndrome is frequent in children admitted with diabetic ketoacidosis/diabetic ketosis (DKA/DK). This study evaluates the interplay of various metabolic factors with occurrence of deranged thyroid function tests in children admitted for management of DKA/DK.Methods: 98 DKA and 96 DK children patients were selected from hospital records, among which individuals on thyroxine replacement, with overt hypothyroidism or positive anti-thyroperoxidase (TPO) antibody were excluded. Tests for liver function, renal function, lipid profile, serum osmolarity, thyroid function, c-peptide levels, and glycosylated hemoglobin were done for all. Children were divided into euthyroid (n=88) and euthyroid sick syndrome（ESS）groups (n=106).Results: The ESS group had a higher level of white blood cell count (WBC), plasma glucose (PG), beta-hydroxybutyric acid (β-HB), triglyceride (TG), anion gap (AG), glycosylated hemoglobin (HbA1c) and a lower level of HCO3-, prealbumin (PA), and albumin (ALB) compared with the euthyroid group (P<0.05). Free T3 (FT3) levels were significantly correlated to β-HB, HCO3-, AG, PA, and HbA1c (r=-0.642, 0.681, -0.377, 0.581, -0.309, respectively; P<0.01). Free T4 （FT4） levels were significantly correlated to β-HB, HCO3-, and ALB levels (r=-0.489, 0.338, 0.529, respectively; P<0.01). TSH levels were significantly affected by HCO3– only (r=-0.28; P<0.01). HCO3– level was the most important factor deciding euthyroid or ESS on logistic regression analysis (OR=0.844, P=0.004, 95%CI=0.751-0.948).Conclusions: Lower levels of free thyroid hormones and occurrence of ESS were associated with a higher degree of acidosis in children with DKA/DK.

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Association between weight status and recreational drug abuse in Korean adolescents

Open Medicine ◽

10.2478/s11536-011-0136-8 ◽

2012 ◽

Vol 7 (2) ◽

pp. 224-229 ◽

Cited By ~ 2

Author(s):

Seong-Ik Baek ◽

Wi-Young So

Keyword(s):

Drug Abuse ◽

Drug Use ◽

Weight Status ◽

Alcohol Intoxication ◽

Risk Behaviour ◽

Overweight And Obesity ◽

Multivariable Logistic Regression Analysis ◽

Recreational Drug ◽

Korean Adolescents ◽

Recreational Drug Use

AbstractThe purpose of this study was to investigate the relationship between weight status and recreational drug use in Korean adolescents. A total of 72,399 adolescent students (38,152 boys and 34,247 girls) from the middle first to high third grade participated in the 5th Korea Youth Risk Behaviour Web-based Survey (KYRBWS-V) project in 2009. They were assessed for body mass index (BMI) and recreational drug abuse. The associations between BMI and recreational drug use were examined using multivariable logistic regression analysis after adjusting for the covariate variables of age, smoking frequency and cigarette consumption, frequency of alcohol consumption and severe alcohol intoxication, amount of alcohol consumed, parents’ education level, economic status, sedentary activities during the week, mental stress, sleep duration, frequency of vigorous and moderate physical activities, and muscular strength exercises during the week. For boys, the odds ratio (OR) (95% confidence interval [CI]) between overweight and drug use were 0.990 (0.723–1.356; p = 0.950) for almost none, 0.939 (0.521–1.693; p = 0.834) for past use, and 0.791 (0.385–1.624; p = 0.523) for present use. The OR (95% CI) between obesity and drug use was 0.731(0.508–1.052; p = 0.091) for almost none, 0.755 (0.389–1.465; p = 0.407) for past use, and 0.701 (0.314–1.565; p = 0.386) for present use. For girls, the OR (95% CI) between overweight and drug use was 1.112 (0.702–1.763; p = 0.650) for almost none, 1.103 (0.464–2.619; p = 0.825) for past use, and 0.927 (0.267–3.218; p = 0.905) for present use. The OR (95% CI) between obesity and drug abuse was 0.594 (0.261–1.352; p = 0.215) for almost none, 1.318 (0.462–3.764; p = 606) for past use, and <0.001(<0.001–<0.001; p = 0.998) for present use. We concluded that recreational drug use had no correlation with overweight and obesity in Korean adolescents.

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Determinants of deranged thyroid function parameters in children admitted for management of diabetic ketoacidosis/diabetic ketosis

10.21203/rs.3.rs-21868/v3 ◽

2020 ◽

Author(s):

Peng Shao ◽

Shujuan Guo ◽

Guimei Li ◽

Daogang Qin ◽

Sen Li ◽

...

Keyword(s):

Diabetic Ketoacidosis ◽

Thyroid Function ◽

Glycosylated Hemoglobin ◽

Overt Hypothyroidism ◽

Thyroid Function Tests ◽

Hydroxybutyric Acid ◽

Free T4 ◽

Free Thyroid Hormones ◽

Euthyroid Sick Syndrome ◽

Diabetic Ketosis

Abstract Background: Euthyroid sick syndrome (ESS) frequently arises in children admitted with diabetic ketoacidosis/diabetic ketosis (DKA/DK). This study evaluates the interplay of various metabolic factors with occurrence of deranged thyroid function tests in children suffering from DKA/DK.Methods: 98 DKA and 96 DK pediatric patients were selected from hospital records. Those on thyroxine replacement, with overt hypothyroidism, or with positive anti-thyroperoxidase (TPO) antibody were excluded. Tests for liver function, renal function, lipid profile, serum osmolarity, thyroid function, c-peptide levels, and glycosylated hemoglobin were done on all patients. Children were divided into euthyroid (n=88) and ESS groups (n=106).Results: The ESS group had a higher level of white blood cell count (WBC), plasma glucose (PG), beta-hydroxybutyric acid (β-HB), triglyceride (TG), anion gap (AG), glycosylated hemoglobin (HbA1c) and a lower level of HCO3-, prealbumin (PA), and albumin (ALB) compared with the euthyroid group (P<0.05). Free T3 (FT3) levels were significantly correlated to β-HB, HCO3-, AG, PA, and HbA1c (r=-0.642, 0.681, -0.377, 0.581, -0.309, respectively; P<0.01). Free T4 (FT4) levels were significantly correlated to β-HB, HCO3-, and ALB levels (r=-0.489, 0.338, 0.529, respectively; P<0.01). TSH levels were significantly affected by HCO3– only (r=-0.28; P<0.01). HCO3– level was the most important factor deciding euthyroid or ESS on logistic regression analysis (OR=0.844, P=0.004, 95%CI=0.751-0.948).Conclusions: Lower levels of free thyroid hormones and occurrence of ESS were associated with a higher degree of acidosis in children with DKA/DK.

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Striking increase in the incidence of infective endocarditis associated with recreational drug abuse in urban South Africa

South African Medical Journal ◽

10.7196/samj.2018.v108i7.13007 ◽

2018 ◽

Vol 108 (7) ◽

pp. 585 ◽

Cited By ~ 7

Author(s):

R Meel ◽

M R Essop

Keyword(s):

South Africa ◽

Drug Abuse ◽

Infective Endocarditis ◽

Recreational Drug ◽

Striking Increase ◽

Urban South

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Diabetic Ketosis and Coma (Continued)

PEDIATRICS ◽

10.1542/peds.48.6.993 ◽

1971 ◽

Vol 48 (6) ◽

pp. 993-994

Author(s):

Gilbert Martin ◽

Robert Schwartz

Keyword(s):

Diabetic Ketoacidosis ◽

Initial Therapy ◽

Glucose Administration ◽

Diabetic Ketosis

I read the article on diabetic ketoacidosis by Robert Schwartz in the May issue of Pediatrics1 and felt that it certainly offered a concise, organized approach to therapy. There are, however, several points which deserve comment. First, it is mentioned, "Initial therapy should avoid glucose administration, especially if marked hypoglycemia is present." This may be correct if levels are in the 600 mg per 100 ml range, but is of questionable value at lower levels.

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