Differential behavioral syndrome evoked in the rats after multiple doses of SSRI fluoxetine with selective MAO inhibitors rasagiline or selegiline

SynopsisDangerous and even fatal interactions can occur in man following combinations of antidepressants which include non-selective MAO inhibitors. To ascertain the causation, interactions reproducing the clinical phenomena have been elicited in animals with these combinations, and the mechanisms involved have been explored by various pharmacological strategies; 5-HT re-uptake inhibitors proved especially hazardous in combination. Interactions could, however, be avoided even with the 5-HT re-uptake inhibitors, by combination with relatively selective MAO A or B inhibitors, an approach with potential clinical value.

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Selenazolyl-hydrazones as Novel Selective MAO Inhibitors With Antiproliferative and Antioxidant Activities: Experimental and In-silico Studies

Frontiers in Chemistry ◽

10.3389/fchem.2018.00247 ◽

2018 ◽

Vol 6 ◽

Cited By ~ 10

Author(s):

Hana Elshaflu ◽

Tamara R. Todorović ◽

Milan Nikolić ◽

Aleksandar Lolić ◽

Aleksandar Višnjevac ◽

...

Keyword(s):

In Silico ◽

Antioxidant Activities ◽

Mao Inhibitors ◽

In Silico Studies ◽

Selective Mao Inhibitors

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Design and synthesis of novel 2-pyrazoline-1-ethanone derivatives as selective MAO inhibitors

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2014.12.010 ◽

2015 ◽

Vol 23 (3) ◽

pp. 515-525 ◽

Cited By ~ 13

Author(s):

Xu Tong ◽

Rui Chen ◽

Tong-Tian Zhang ◽

Yan Han ◽

Wen-Jian Tang ◽

...

Keyword(s):

Mao Inhibitors ◽

Design And Synthesis ◽

Selective Mao Inhibitors

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Dose-Response Aggregometry in Maternal/Neonatal Platelets

Thrombosis and Haemostasis ◽

10.1055/s-0038-1647052 ◽

1988 ◽

Vol 60 (02) ◽

pp. 314-318 ◽

Cited By ~ 34

Author(s):

A M A Gader ◽

H Bahakim ◽

F A Jabbar ◽

A L Lambourne ◽

T H Gaafar ◽

...

Keyword(s):

Arachidonic Acid ◽

Dose Response ◽

Lag Phase ◽

Phase Slope ◽

Multiple Doses ◽

Nonpregnant Adult ◽

Aggregation Of Platelets

SummaryThe aggregation of platelets collected from maternal/neonatal pairs (n = 240) at the time of childbirth, was studied in response to multiple doses of ADP, collagen, arachidonic acid and ristocetin. Similar responses were obtained from healthy nonpregnant adult controls for comparison. The lag phase, slope of the aggregation curves as well as maximum aggregation (MA%) were recorded and analysed. Neonatal and adult platelets exhibited more enhanced responses to decreasing doses of ADP, arachidonic acid and ristocetin, than maternal platelets. These enhanced responses were exhibited more consistantly in the slopes of the aggregation curves than in MA%. Although neonatal platelets have shown longer lag phase in their responses to collagen, the rate of the aggregation reaction was significantly faster than maternal platelets, with no differences in MA%. These results contradict many previous reports suggesting impaired aggregation responses of neonatal platelets to these agonist. The possible reasons for these contradictions were discussed.

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