Antiretroviral drug resistance mutations in the reverse transcriptase gene of HIV-1 isolates from Northern Indian patients: a follow-up study

2010 ◽  
Vol 155 (4) ◽  
pp. 563-569 ◽  
Author(s):  
Shubhasree Dutta Choudhury ◽  
Alok K. Chaudhury ◽  
Rajesh Kalra ◽  
Raiees Andrabi ◽  
Naveet Wig ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Reverse Transcriptase ◽  
Reverse Transcriptase Gene ◽  
Resistance Mutations ◽  
Antiretroviral Drug Resistance ◽  
Follow Up Study ◽  
Drug Resistance Mutations ◽  
Antiretroviral Drug ◽  
Hiv 1

scholarly journals ACQUIRED ANTIRETROVIRAL DRUG RESISTANCE MUTATIONS UPON TREATMENT FAILURE IN HIV-1 INFECTED PEDIATRIC PATIENTS IN CENTRAL BRAZIL

2020 ◽  
Vol 49 (2) ◽  
pp. 79-93
Author(s):  
Maly Albuquerque ◽  
Solomar Martins Marques ◽  
Ricardo Vieira Teles Filho ◽  
Paulo Sergio Sucasas Costa
Keyword(s):  
Drug Resistance ◽  
Reverse Transcriptase ◽  
Children And Adolescents ◽  
Resistance Mutations ◽  
Central Brazil ◽  
Antiretroviral Drug Resistance ◽  
Drug Resistance Mutations ◽  
Antiretroviral Drug ◽  
Hiv 1

Antiretroviral drug-resistance mutations compromise the successful treatment of children and adolescents infected with human immunodeficiency virus type 1 (HIV-1). We describe the clinical, virological, and immunological follow-up of a cohort of children and adolescents perinatally infected with HIV-1 treated at Hospital Estadual de Doenças Tropicais Dr. Anuar Auad – HDT, in Central Brazil, after therapeutic failure related to drug resistance mutations.We analyzed the results of the genotypic test (protease codons 1–99 and reverse transcriptase codons 1–325) performed from 2003 to 2015. The ARV susceptibility profile was analyzed according to Stanford HIV drug resistance database. A total of 65 patients (median age of 10 years; range, 18 m–18 y) with therapeutic failure (after a median of 55 months of follow up; range, 9 m–13 y) and plasma levels of HIV-1 RNA greater than 1,000 copies/mL which were included and demonstrated mutations in: nucleoside reverse transcriptase inhibitors (NRTIs), 98.5%; non nucleoside reverse transcriptase inhibitors (NNRTIs), 75.4%; and protease inhibitors (PI), 44.6%. The most frequent NRTI mutations were found in codon T215 (83.1%) with a predominance of T215Y (56.9%), followed by M184V (69.3%). In the NNRTI class, mutations K103N (36.9%) and 190A (23.1%) were predominant, and, in the protease, mutations 54VL (35.4%) and 82ASTL (32.3%) were found in approximately the same proportion, with a predominance of the M54V mutation. These results demonstrate the high levels of resistance to different classes of antiretrovirals in HIV-infected children and adolescents and the importance of genotypic resistance tests in this population.KEY WORDS: HIV; drug resistance; genotypes; child; adolescent.

scholarly journals HIV-1 pol gene diversity and antiretroviral drug resistance mutations in Itanhaém city, Brazil

2008 ◽  
Vol 11 (Suppl 1) ◽  
pp. P196
Author(s):  
RB Rodrigues-Matias ◽  
KCP Guatelli ◽  
RF Ambar ◽  
NB Duarte ◽  
LH Gagliani ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Gene Diversity ◽  
Resistance Mutations ◽  
Antiretroviral Drug Resistance ◽  
Drug Resistance Mutations ◽  
Antiretroviral Drug ◽  
Hiv 1

Prevalence of antiretroviral drug resistance mutations and HIV-1 non-B subtypes in newly diagnosed drug-naïve patients in Slovenia, 2000–2004

2006 ◽  
Vol 118 (1-2) ◽  
pp. 156-163 ◽  
Author(s):  
Dunja Z. Babič ◽  
Mojca Zelnikar ◽  
Katja Seme ◽  
Anne-Mieke Vandamme ◽  
Joke Snoeck ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Newly Diagnosed ◽  
Resistance Mutations ◽  
Antiretroviral Drug Resistance ◽  
Drug Resistance Mutations ◽  
Antiretroviral Drug ◽  
Drug Naïve ◽  
Hiv 1

Prevalence of HIV-1 Subtypes and Antiretroviral Drug Resistance Mutations in Nepal

2016 ◽  
Vol 14 (6) ◽  
pp. 517-524 ◽  
Author(s):  
Nirajan Bhusal ◽  
Ruengpung Sutthent ◽  
Navin Horthongkham ◽  
Niracha Athipanyasilp ◽  
Wannee Kantakamalakul
Keyword(s):  
Drug Resistance ◽  
Resistance Mutations ◽  
Antiretroviral Drug Resistance ◽  
Drug Resistance Mutations ◽  
Antiretroviral Drug ◽  
Hiv 1

scholarly journals Antiretroviral Drug Resistance Mutations Sustain or Enhance CTL Recognition of Common HIV-1 Pol Epitopes

2004 ◽  
Vol 172 (11) ◽  
pp. 7212-7219 ◽  
Author(s):  
Rosemarie D. Mason ◽  
M. Ian Bowmer ◽  
Constance M. Howley ◽  
Maureen Gallant ◽  
Jennifer C. E. Myers ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Resistance Mutations ◽  
Antiretroviral Drug Resistance ◽  
Drug Resistance Mutations ◽  
Antiretroviral Drug ◽  
Hiv 1

scholarly journals Transmitted antiretroviral drug resistance mutations in newly diagnosed HIV-1 positive patients in Turkey

2014 ◽  
Vol 17 ◽  
pp. 19750 ◽  
Author(s):  
Murat Sayan ◽  
Fatma Sargýn ◽  
Dilara Inan ◽  
Dilek Yýldýz Sevgi ◽  
Aysel Kocagül Celikbas ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Newly Diagnosed ◽  
Resistance Mutations ◽  
Antiretroviral Drug Resistance ◽  
Drug Resistance Mutations ◽  
Antiretroviral Drug ◽  
Hiv 1
Sign in / Sign up

Export Citation Format

Share Document