Identification of a conserved linear neutralizing epitope recognized by monoclonal antibody 9A9 against serotype A foot-and-mouth disease virus

2016 ◽  
Vol 161 (10) ◽  
pp. 2705-2716 ◽  
Author(s):  
Weifeng Liang ◽  
Guohui Zhou ◽  
Wenming Liu ◽  
Baolin Yang ◽  
Chaosi Li ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Disease Virus ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Neutralizing Epitope ◽  
Serotype A ◽  
Mouth Disease Virus ◽  
Foot And Mouth

Cross-protective efficacy of engineering serotype A foot-and-mouth disease virus vaccine against the two pandemic strains in swine

Vaccine ◽  
2015 ◽  
Vol 33 (43) ◽  
pp. 5772-5778 ◽  
Author(s):  
Haixue Zheng ◽  
Kaiqi Lian ◽  
Fan Yang ◽  
Ye Jin ◽  
Zixiang Zhu ◽  
...  
Keyword(s):  
Disease Virus ◽  
Virus Vaccine ◽  
Protective Efficacy ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Serotype A ◽  
Mouth Disease Virus ◽  
Foot And Mouth ◽  
Pandemic Strains

scholarly journals Use of ENABL® adjuvant to increase the potency of an adenovirus-vectored foot-and-mouth disease virus serotype A subunit vaccine

Vaccine ◽  
2018 ◽  
Vol 36 (8) ◽  
pp. 1078-1084 ◽  
Author(s):  
José Barrera ◽  
Christopher Schutta ◽  
Melia Pisano ◽  
Marvin J. Grubman ◽  
David A. Brake ◽  
...  
Keyword(s):  
Disease Virus ◽  
Subunit Vaccine ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Serotype A ◽  
Mouth Disease Virus ◽  
Virus Serotype ◽  
Foot And Mouth ◽  
A Subunit

Evolution of foot-and-mouth disease virus serotype A capsid coding (P1) region on a timescale of three decades in an endemic context

2016 ◽  
Vol 41 ◽  
pp. 36-46 ◽  
Author(s):  
Biswajit Das ◽  
Jajati K. Mohapatra ◽  
Veena Pande ◽  
Saravanan Subramaniam ◽  
Aniket Sanyal
Keyword(s):  
Disease Virus ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Serotype A ◽  
Mouth Disease Virus ◽  
Virus Serotype ◽  
Foot And Mouth

scholarly journals Insertion of type O-conserved neutralizing epitope into the foot-and-mouth disease virus type Asia1 VP1 G-H loop: effect on viral replication and neutralization phenotype

2012 ◽  
Vol 93 (7) ◽  
pp. 1442-1448 ◽  
Author(s):  
Haiwei Wang ◽  
Mei Xue ◽  
Decheng Yang ◽  
Guohui Zhou ◽  
Donglai Wu ◽  
...  
Keyword(s):  
Disease Virus ◽  
Neutralizing Antibodies ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Neutralizing Epitope ◽  
Fmdv Serotypes ◽  
Mouth Disease Virus ◽  
Foot And Mouth ◽  
Fmdv Type ◽  
Neutralizing Epitopes

Previously, we finely mapped the neutralizing epitopes recognized by foot-and-mouth disease virus (FMDV) type Asia1-specific mAb 3E11 and FMDV type O-specific mAb 8E8. In this study, we engineered recombinant FMDVs of the serotype Asia1 (rFMDVs) displaying the type O-neutralizing epitope recognized by the mAb 8E8. These epitope-inserted viruses were genetically stable and exhibited growth properties that were similar to those of their parental virus. Importantly, the recombinant virus rFMDV-C showed neutralization sensitivity to both FMDV type Asia1 and type O mAbs, as well as to polyclonal antibodies. These results indicated that this epitope-inserted virus has the potential to induce neutralizing antibodies against both FMDV type Asia1 and type O. Our results demonstrated that the G-H loop of FMDV type Asia1 effectively displays the protective neutralizing epitopes of other FMDV serotypes, making this an attractive approach for the design of novel FMDV vaccines.

Fine mapping of a foot-and-mouth disease virus epitope recognized by serotype-independent monoclonal antibody 4B2

2011 ◽  
Vol 49 (1) ◽  
pp. 94-101 ◽  
Author(s):  
Yongzhong Yu ◽  
Haiwei Wang ◽  
Lei Zhao ◽  
Chunyuan Zhang ◽  
Zhigang Jiang ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Disease Virus ◽  
Fine Mapping ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Mouth Disease Virus ◽  
Foot And Mouth ◽  
Virus Epitope

scholarly journals Near-Complete Genome Sequence of a Potential Foot-and-Mouth Disease Virus Serotype A Vaccine Strain Isolated from Bangladesh

2019 ◽  
Vol 8 (37) ◽  
Author(s):  
M. Al Amin ◽  
M. Rahmat Ali ◽  
A. S. M. Rubayet Ul Alam ◽  
Mohammad Anwar Siddique ◽  
Huzzat Ullah ◽  
...  
Keyword(s):  
Disease Virus ◽  
Vaccine Strain ◽  
Genome Sequence ◽  
Complete Genome Sequence ◽  
Complete Genome ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Serotype A ◽  
Mouth Disease Virus ◽  
Foot And Mouth

The near-complete genome sequence of foot-and-mouth disease virus (FMDV) serotype A potential vaccine strain BAN/CH/Sa-304/2016 is reported here. Its genome revealed antigenic heterogeneity with the current Indian vaccine strain IND40/00, with four amino acid substitutions in antigenically critical sites of the VP1 protein.

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