Thirteen decades of peptide synthesis: key developments in solid phase peptide synthesis and amide bond formation utilized in peptide ligation

Amino Acids ◽  
2017 ◽  
Vol 50 (1) ◽  
pp. 39-68 ◽  
Author(s):  
Da’san M. M. Jaradat
Keyword(s):  
Peptide Synthesis ◽  
Solid Phase ◽  
Bond Formation ◽  
Solid Phase Peptide Synthesis ◽  
Amide Bond ◽  
Amide Bond Formation ◽  
Peptide Ligation

scholarly journals Real-time monitoring of solid-phase peptide synthesis using a variable bed flow reactor

2019 ◽  
Vol 55 (97) ◽  
pp. 14598-14601 ◽  
Author(s):  
Eric T. Sletten ◽  
Manuel Nuño ◽  
Duncan Guthrie ◽  
Peter H. Seeberger
Keyword(s):  
Real Time ◽  
Peptide Synthesis ◽  
Flow Reactor ◽  
Solid Phase ◽  
Bond Formation ◽  
Solid Phase Peptide Synthesis ◽  
Amide Bond ◽  
Real Time Monitoring ◽  
Amide Bond Formation

Integration of a pressure-based variable bed flow reactor into an automated solid-phase peptide synthesizer allowed for monitoring of on-resin aggregation and incomplete amide bond formation in real-time.

Amide Bond Formation with a New Fluorous Carbodiimide:  Separation by Reverse Fluorous Solid-Phase Extraction

2007 ◽  
Vol 9 (21) ◽  
pp. 4167-4170 ◽  
Author(s):  
Carlos del Pozo ◽  
Adam I. Keller ◽  
Tadamichi Nagashima ◽  
Dennis P. Curran
Keyword(s):  
Solid Phase Extraction ◽  
Solid Phase ◽  
Bond Formation ◽  
Amide Bond ◽  
Phase Extraction ◽  
Amide Bond Formation

scholarly journals Oligonucleotides with 2′-O-carboxymethyl group: synthesis and 2′-conjugation via amide bond formation on solid phase

2004 ◽  
Vol 2 (19) ◽  
pp. 2793-2797 ◽  
Author(s):  
Anna Kachalova ◽  
Eugeny Zubin ◽  
Dmitry Stetsenko ◽  
Michael Gait ◽  
Tatiana Oretskaya
Keyword(s):  
Solid Phase ◽  
Bond Formation ◽  
Amide Bond ◽  
Amide Bond Formation

Substrate-Controlled Amide Bond Formation: Innovation of Peptide Synthesis

2021 ◽  
Vol 79 (5) ◽  
pp. 382-390
Author(s):  
Tomohiro Hattori ◽  
Wataru Muramatsu ◽  
Hisashi Yamamoto
Keyword(s):  
Peptide Synthesis ◽  
Bond Formation ◽  
Amide Bond ◽  
Amide Bond Formation

A new reagent for the mediation of amide bond formation in peptide synthesis.

1984 ◽  
Vol 25 (42) ◽  
pp. 4825-4828 ◽  
Author(s):  
Robert Ramage ◽  
Christopher P. Ashton ◽  
David Hopton ◽  
Maxwell J. Parrott
Keyword(s):  
Peptide Synthesis ◽  
Bond Formation ◽  
Amide Bond ◽  
Amide Bond Formation

Metal-free approach for hindered amide-bond formation with hypervalent iodine(iii) reagents: application to hindered peptide synthesis

2021 ◽  
Author(s):  
Hyo-Jun Lee ◽  
Xiao Huang ◽  
Shigeyoshi Sakaki ◽  
Keiji Maruoka
Keyword(s):  
Peptide Synthesis ◽  
Hydrogen Fluoride ◽  
Bond Formation ◽  
Amide Bond ◽  
Hypervalent Iodine ◽  
Fluoride Complex ◽  
Metal Free ◽  
Amino Esters ◽  
Amide Bond Formation

A new, bulky amide and peptide synthesis with hypervalent iodine(iii) reagent/pyridine–hydrogen fluoride complex under mild and metal-free conditions was developed by using α-amino esters with potential activating group (PAG) at the ester residue.

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