scholarly journals Oligonucleotides with 2′-O-carboxymethyl group: synthesis and 2′-conjugation via amide bond formation on solid phase

2004 ◽  
Vol 2 (19) ◽  
pp. 2793-2797 ◽  
Author(s):  
Anna Kachalova ◽  
Eugeny Zubin ◽  
Dmitry Stetsenko ◽  
Michael Gait ◽  
Tatiana Oretskaya
Keyword(s):  
Solid Phase ◽  
Bond Formation ◽  
Amide Bond ◽  
Amide Bond Formation

Amide Bond Formation with a New Fluorous Carbodiimide:  Separation by Reverse Fluorous Solid-Phase Extraction

2007 ◽  
Vol 9 (21) ◽  
pp. 4167-4170 ◽  
Author(s):  
Carlos del Pozo ◽  
Adam I. Keller ◽  
Tadamichi Nagashima ◽  
Dennis P. Curran
Keyword(s):  
Solid Phase Extraction ◽  
Solid Phase ◽  
Bond Formation ◽  
Amide Bond ◽  
Phase Extraction ◽  
Amide Bond Formation

A New and Efficient Method for Synthesis of 5′-Conjugates of Oligonucleotides through Amide-Bond Formation on Solid Phase

2002 ◽  
Vol 85 (8) ◽  
pp. 2409-2416 ◽  
Author(s):  
Anna V. Kachalova ◽  
Dmitry A. Stetsenko ◽  
Elena A. Romanova ◽  
Vadim N. Tashlitsky ◽  
Michael J. Gait ◽  
...  
Keyword(s):  
Efficient Method ◽  
Solid Phase ◽  
Bond Formation ◽  
Amide Bond ◽  
Amide Bond Formation

scholarly journals Real-time monitoring of solid-phase peptide synthesis using a variable bed flow reactor

2019 ◽  
Vol 55 (97) ◽  
pp. 14598-14601 ◽  
Author(s):  
Eric T. Sletten ◽  
Manuel Nuño ◽  
Duncan Guthrie ◽  
Peter H. Seeberger
Keyword(s):  
Real Time ◽  
Peptide Synthesis ◽  
Flow Reactor ◽  
Solid Phase ◽  
Bond Formation ◽  
Solid Phase Peptide Synthesis ◽  
Amide Bond ◽  
Real Time Monitoring ◽  
Amide Bond Formation

Integration of a pressure-based variable bed flow reactor into an automated solid-phase peptide synthesizer allowed for monitoring of on-resin aggregation and incomplete amide bond formation in real-time.

Diethylphosphoryl-OxymaB (DEPO-B) as a Solid Coupling Reagent for Amide Bond Formation

2018 ◽  
Vol 16 (1) ◽  
pp. 30-33
Author(s):  
Ashish Kumar ◽  
Yahya E. Jad ◽  
Ayman El-Faham ◽  
Beatriz G. de la Torre ◽  
Fernando Albericio
Keyword(s):  
Bond Formation ◽  
Hydrolytic Stability ◽  
Solid Material ◽  
Amide Bond ◽  
Amide Bond Formation ◽  
Coupling Reagent

A new phosphonium based coupling reagent DEPO-B has been synthesized from 5- (hydroxyimino)-1,3-dimethylpyrimidine-2,4,6 (1H,3H,5H)-trione (Oxyma B) and diethyl chlorophosphate in presence of base. It is a solid material and the hydrolytic stability and solubility was evaluated for confirming its capability for usage in automated peptide synthesizer.

A Review of Amide Bond Formation in Microwave Organic Synthesis

2014 ◽  
Vol 11 (4) ◽  
pp. 592-604 ◽  
Author(s):  
Natalia Lukasik ◽  
Ewa Wagner-Wysiecka
Keyword(s):  
Organic Synthesis ◽  
Bond Formation ◽  
Amide Bond ◽  
Amide Bond Formation

A computational study on the mechanism of ynamide-mediated amide bond formation from carboxylic acids and amines

2017 ◽  
Vol 15 (30) ◽  
pp. 6367-6374 ◽  
Author(s):  
Song-Lin Zhang ◽  
Hai-Xing Wan ◽  
Zhu-Qin Deng
Keyword(s):  
Reaction Mechanism ◽  
Carboxylic Acids ◽  
Computational Study ◽  
Bond Formation ◽  
Amide Bond ◽  
Reactivity Pattern ◽  
Amide Bond Formation ◽  
Coupling Reagent ◽  
Catalytic Effects ◽  
Acid Substrate

A detailed computational study is presented on the reaction mechanism of ynamide-mediated condensation of carboxylic acids with amines to produce amides, which elucidates the reactivity pattern of the coupling reagent ynamide and discloses crucial bifunctional catalytic effects of the carboxylic acid substrate during aminolysis.

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