Head and neck free tissue transfer in a patient with factor V Leiden: case report and review of the literature

2021 ◽  
Author(s):  
Ricardo Lugo ◽  
Fawaz Alotaibi ◽  
Brett Shirley ◽  
Dongsoo David Kim ◽  
Paul Covello ◽  
...  
Keyword(s):  
Case Report ◽  
Head And Neck ◽  
Factor V Leiden ◽  
Free Tissue Transfer ◽  
Factor V ◽  
Review Of The Literature ◽  
Tissue Transfer

The Diagnosis and Clinical Manifestations of Activated Protein C Resistance: A Case Report and Review of the Literature

1996 ◽  
Vol 1 (4) ◽  
pp. 275-280 ◽  
Author(s):  
Howard Daniel Hoerl ◽  
Aldo Tabares ◽  
Kandice Kottke-Marchant
Keyword(s):  
Case Report ◽  
Protein C ◽  
Activated Protein C ◽  
Clinical Manifestations ◽  
Factor V Leiden ◽  
Laboratory Diagnosis ◽  
Factor V ◽  
Review Of The Literature ◽  
Activated Protein C Resistance ◽  
Genetic Anomaly

Activated protein C resistance (APCR) is a recently discovered, medically important cause of venous thrombosis. More than 95% of cases are due to factor V Leiden (FVL), a mutated form of factor V that is resistant to degradation by activated protein C. The prevalence of this disorder, which is inherited in an autosomal dominant fashion, is approximately 5% among asymptomatic people of European heritage. In addition, 20 to 60% of patient cohorts with previous thrombosis demonstrate APCR, making it the most common known genetic cause of abnormal thrombophilia. Current laboratory techniques available for diagnosis include functional assays, such as the APC ratio, as well as DNA-based tests that detect the specific genetic anomaly responsible for FVL. A case report is presented, along with a review of the literature highlighting epidemiology, pathogenesis, clinical features and methods for laboratory diagnosis.

Controversies in free tissue transfer for head and neck cancer: A review of the literature

Head & Neck ◽  
2019 ◽  
Vol 41 (9) ◽  
pp. 3457-3463 ◽  
Author(s):  
Marianne Abouyared ◽  
Andrew P. Katz ◽  
Liliana Ein ◽  
Jill Ketner ◽  
Zoukaa Sargi ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Free Tissue Transfer ◽  
Review Of The Literature ◽  
Tissue Transfer

Cortical Blindness After a Failed Free Tissue Transfer: A Case Report and Review of the Literature

1995 ◽  
Vol 34 (4) ◽  
pp. 431-434 ◽  
Author(s):  
Robert E. Tuchler ◽  
Andrew T. Lyos ◽  
A Melinda Rainey ◽  
Maher M. Anous
Keyword(s):  
Case Report ◽  
Free Tissue Transfer ◽  
Cortical Blindness ◽  
Review Of The Literature ◽  
Tissue Transfer

scholarly journals Head and neck myxofibrosarcoma: a case report and review of the literature

2014 ◽  
Vol 8 (1) ◽  
Author(s):  
Giovanni Dell’Aversana Orabona ◽  
Giorgio Iaconetta ◽  
Vincenzo Abbate ◽  
Pasquale Piombino ◽  
Antonio Romano ◽  
...  
Keyword(s):  
Case Report ◽  
Head And Neck ◽  
Review Of The Literature

scholarly journals Mechanical Anastomotic Coupling Device versus Hand-sewn Venous Anastomosis in Head and Neck Reconstruction—An Analysis of 1694 Venous Anastomoses

2021 ◽  
Vol 54 (02) ◽  
pp. 118-123
Author(s):  
Rajan Arora ◽  
Kripa Shanker Mishra ◽  
Hemant T. Bhoye ◽  
Ajay Kumar Dewan ◽  
Ravi K. Singh ◽  
...  
Keyword(s):  
Venous Thrombosis ◽  
Head And Neck ◽  
Free Tissue Transfer ◽  
Effective Alternative ◽  
Head And Neck Reconstruction ◽  
Venous Anastomosis ◽  
Neck Reconstruction ◽  
Coupling Device ◽  
Tissue Transfer ◽  
Flap Loss

Abstract Background There is a steep learning curve to attain a consistently good result in microvascular surgery. The venous anastomosis is a critical step in free-tissue transfer. The margin of error is less and the outcome depends on the surgeon’s skill and technique. Mechanical anastomotic coupling device (MACD) has been proven to be an effective alternative to hand-sewn (HS) technique for venous anastomosis, as it requires lesser skill. However, its feasibility of application in emerging economy countries is yet to be established. Material and Method We retrospectively analyzed the data of patients who underwent free-tissue transfer for head and neck reconstruction between July 2015 and October 2020. Based on the technique used for the venous anastomosis, the patients were divided into an HS technique and MACD group. Patient characteristics and outcomes were measured. Result A total of 1694 venous anastomoses were performed during the study period. There were 966 patients in the HS technique group and 719 in the MACD group. There was no statistically significant difference between the two groups in terms of age, sex, prior radiotherapy, prior surgery, and comorbidities. Venous thrombosis was noted in 62 (6.4%) patients in the HS technique group and 7 (0.97%) in the MACD group (p = 0.000). The mean time taken for venous anastomosis in the HS group was 17 ± 4 minutes, and in the MACD group, it was 5 ± 2 minutes (p = 0.0001). Twenty-five (2.56%) patients in the HS group and 4 (0.55%) patients in MACD group had flap loss (p = 0.001). Conclusion MACD is an effective alternative for HS technique for venous anastomosis. There is a significant reduction in anastomosis time, flap loss, and return to operation theater due to venous thrombosis. MACD reduces the surgeon’s strain, especially in a high-volume center. Prospective randomized studies including economic analysis are required to prove the cost-effectiveness of coupler devices.

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