Scleroderma Renal Crisis and Concurrent Isolated Pulmonary Hypertension in Mixed Connective Tissue Disease and Overlap Syndrome: Report of Two Cases

2002 ◽  
Vol 21 (2) ◽  
pp. 164-169 ◽  
Author(s):  
G. N. Andersen ◽  
J. Vasko
Keyword(s):  
Pulmonary Hypertension ◽  
Connective Tissue ◽  
Connective Tissue Disease ◽  
Mixed Connective Tissue Disease ◽  
Overlap Syndrome ◽  
Scleroderma Renal Crisis ◽  
Renal Crisis ◽  
Syndrome Report

scholarly journals Renal Crisis Due to Intimal Hyperplasia in a Patient with Mixed Connective Tissue Disease (MCTD) Accompanied by Pulmonary Hypertension.

2001 ◽  
Vol 40 (12) ◽  
pp. 1250-1253 ◽  
Author(s):  
Toru YAMAGUCHI ◽  
Shiro OHSHIMA ◽  
Toshio TANAKA ◽  
Satoshi TSUKADA ◽  
Masato MATSUSHITA ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Connective Tissue ◽  
Connective Tissue Disease ◽  
Intimal Hyperplasia ◽  
Mixed Connective Tissue Disease ◽  
Renal Crisis

scholarly journals Scleroderma Renal Crisis in Mixed Connective Tissue Disease With Full Renal Recovery Within 3 Months: A Case Report With Expanding Treatment Modalities to Treat Each Clinical Sign as an Independent Entity

2017 ◽  
Vol 5 (4) ◽  
pp. 232470961773401 ◽  
Author(s):  
Jordana Cheta ◽  
Suresh Rijhwani ◽  
Harlan Rust
Keyword(s):  
Connective Tissue ◽  
Connective Tissue Disease ◽  
Mixed Connective Tissue Disease ◽  
Clinical Suspicion ◽  
Renal Recovery ◽  
Treatment Modalities ◽  
Prognostic Indicators ◽  
Renal Outcome ◽  
Scleroderma Renal Crisis ◽  
Renal Crisis

Mixed connective tissue disease (MCTD) is a rheumatologic overlap syndrome that can present with symptoms of systemic lupus erythematous, scleroderma, and polymyositis. A severe but rare complication that can occur in MCTD is scleroderma renal crisis. With multiple poor prognostic indicators, the renal outcome is usually poor. The clinical and histological picture is one of a thrombotic microangiopathy. Clinical suspicion has to be high for additional thrombotic or autoimmune processes coexisting due to associated morbidity. In this article, we report a rare case of scleroderma renal crisis in a patient with MCTD who we treated with plasma exchange for clinical suspicion for an underlying thrombotic thrombocytopenia and mycophenolate mofetil for MCTD. The patient had multiple poor prognostic indicators yet made a full renal recovery in less than 3 months.

scholarly journals Scleroderma Renal Crisis in a Case of Mixed Connective Tissue Disease Treated Successfully with Angiotensin-Converting Enzyme Inhibitors

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Jomana Madieh ◽  
Iman Khamayseh ◽  
Alaa Hrizat ◽  
Abdurrahman Hamadah ◽  
Kamel Gharaibeh
Keyword(s):  
Connective Tissue ◽  
Connective Tissue Disease ◽  
Ace Inhibitors ◽  
Lupus Erythematosus ◽  
Mixed Connective Tissue Disease ◽  
Enzyme Inhibitors ◽  
Angiotensin Converting Enzyme Inhibitors ◽  
Scleroderma Renal Crisis ◽  
Converting Enzyme Inhibitors ◽  
Renal Crisis

Mixed connective tissue disease (MCTD) is a rheumatic disease syndrome with overlapping features of scleroderma, systemic lupus erythematosus, and polymyositis. An extremely rare but serious complication that can occur in MCTD is scleroderma renal crisis (SRC). There have been different approaches to the treatment of SRC associated with MCTD. We present a case of MCTD with chronic features of Raynaud’s phenomenon, dermatomyositis, and thrombocytopenia complicated with acute SRC which showed a great response to ACE inhibitors. Here, we advise the early and aggressive use of ACE inhibitors as soon as SRC is suspected.

Mixed connective tissue disease: a case with scleroderma renal crisis following abortion

2006 ◽  
Vol 26 (9) ◽  
pp. 1545-1547 ◽  
Author(s):  
Mehmet Celikbilek ◽  
Rengin Elsurer ◽  
Baris Afsar ◽  
Handan B. Ozdemir ◽  
Siren Sezer ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Connective Tissue Disease ◽  
Mixed Connective Tissue Disease ◽  
Scleroderma Renal Crisis ◽  
Renal Crisis
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