Mean platelet volume as a surrogate marker of inflammation in systemic lupus erythematosus

2014 ◽  
Vol 33 (11) ◽  
pp. 1691-1692 ◽  
Author(s):  
Ercan Varol ◽  
Mehmet Ozaydin
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Mean Platelet Volume ◽  
Surrogate Marker ◽  
Systemic Lupus ◽  
Platelet Volume

scholarly journals Mean platelet volume as a surrogate marker of disease activity in systemic lupus erythematosus

2014 ◽  
Vol 9 ◽  
pp. S32 ◽  
Author(s):  
M.M. Kavitha ◽  
M. Madheshwaran ◽  
T.N. Tamilselvam ◽  
J. Euphrasia Latha ◽  
S. Rajeswari
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Disease Activity ◽  
Lupus Erythematosus ◽  
Mean Platelet Volume ◽  
Surrogate Marker ◽  
Systemic Lupus ◽  
Platelet Volume

scholarly journals Combined Detection of Mean Platelet Volume and Immunoglobins as a Strategy for the Diagnosis of Systemic Lupus Erythematosus

2019 ◽  
Vol 2 (4) ◽  
pp. 19
Author(s):  
Changzhi Xu ◽  
Zhizhi Xie ◽  
Yanhua Yi ◽  
Donglin Zhu ◽  
Yun Xi
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Renal Impairment ◽  
Lupus Erythematosus ◽  
Mean Platelet Volume ◽  
Test Method ◽  
Control Group ◽  
Systemic Lupus ◽  
Platelet Volume ◽  
Reactive Protein ◽  
Complex Process

Objective:To explore the possibility of diagnosing and monitoring patients with systemic lupus erythematosus (SLE) using the combination of mean platelet volume (MPV) and routine immunoglobulin test. Method:116 patients with SLE were divided into 3 groups according to their clinical characteristics, including 29 patients with renal impairment, 44 cases of active stage and 43 cases of inactive patients. 40 healthy subjects were randomly selected as controls. Subjects were tested for routine blood test and plasma Immunoglobins, such as IgG, IgA, IgM, C3, C4, CH50, CRP. The results were analyzed and the characteristics of each group of subjects were determined, the correlation between test results and diagnosis were studied. Result: In comparison to the control group, the serum level of MPV, C3 and C4 were decreased (P<0.05), and C reactive protein level was elevated (P<0.001) in the three groups of SLE patients. The IgG level in active and inactive SLE patients was increased (P<0.0001), CH50 level was decreased in patients with inactive SLE (P<0.05), IgA level of active SLE subjects was found to be elevated (P<0.05), IgM in patients with renal impairment was decreased (P<0.05). Other than that, no other significant characteristic were found. Conclusion: The pathogenesis of SLE is a complex process involving multiple factors. The changes of MPV, IgG, IgA, IgM, C3, C4, CH50 and CRP in SLE patients are characteristic parameters. The combination of the above indicators can help to determine the diagnosis and staging of SLE. The timely diagnosis and treatment of SLE patients has important clinical significance in protecting the organ function of SLE patients and improving the prognosis.

scholarly journals Correlation Between Mex-Sledai and Mean Platelet Volume In Systemic Lupus Erythematosus Patients

2021 ◽  
Vol 12 (2) ◽  
pp. 293-301
Author(s):  
Dr. Ayu Paramaiswari,SpPD, K-R ◽  
Dody Hendro Susilo ◽  
Deddy Nur Wachid Achadiono
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Negative Correlation ◽  
Lupus Erythematosus ◽  
Mean Platelet Volume ◽  
Previous History ◽  
Platelet Activity ◽  
Systemic Lupus ◽  
Platelet Volume ◽  
Early Detection Of Disease ◽  
Clinical Phenotypes

A B S T R A C TBackground. Systemic lupus erythematosus (SLE) is a chronic autoimmunedisease which has a variety of clinical phenotypes with a complex clinical course.The clinical phenotypes are highly variable which can be characterized by acuteattacks, active periods, controllable or remission. Mean platelet volume (MPV) is astraightforward accessible indicator of platelet activity and is associated withsystemic inflammation. The routine usage of MPV as markers for disease activityin SLE remains problematic. Early detection of disease progression is pivotal in themanagement of SLE for obtaining better outcomes. Objective. The study aimed toconfirm that the measurement of the disease severity in patients with SLE usingMex-SLEDAI has a negative correlation with the decrease of MPV value. Methods.This cross-sectional analytic descriptive study was conducted using secondary datafrom the medical records of patients with SLE older than 18 years of age who werenot taking antiplatelets in the Internal Medicine policlinic of Dr. Sardjito GeneralHospital in 2018. Patients with a previous history of cardiovascular andcerebrovascular events, malignancies, receiving a treatment for infections,including sepsis, chronic infections (i.e. tuberculosis, cytomegalovirus, herpessimplex, herpes zoster), HIV, hepatitis B or hepatitis C, and incomplete data ofmedical record were excluded. The correlation between SLEDAI Mex and MPVvalues was evaluated using the Spearman's correlation test. Results. Sixty-sevensubjects (65 women, 2 men) aged 34 ± 11 years were recruited in the study. Themedian duration of diagnosis was 38,2 ± 45,7 months. Arthritis, skin rash andphotosensitivity were identified in 81,1%, 53,7%, and 46,3% of patients,respectively. The Mex-SLEDAI score ranged from 0 to 16. The average of MPV valueis 9.73 ± 1.21 fL. A significant correlation between MPV and SLEDAI Mex wasobserved (p = 0.03 (p <0.05), r = -0.255). Conclusion. The more severe SLE diseaseactivity (based on the Mex-SLEDAI scoring), the more negative correlation with theMPV value.

Mean Platelet Volume Could Reflect Disease Activity of Adult Patients With Systemic Lupus Erythematosus

2016 ◽  
Vol 62 (07/2016) ◽  
Author(s):  
Mingjian Bai ◽  
Lingsheng Xing ◽  
Jing Feng ◽  
Chanjuan Cui ◽  
Lei Huang ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Disease Activity ◽  
Lupus Erythematosus ◽  
Mean Platelet Volume ◽  
Adult Patients ◽  
Systemic Lupus ◽  
Platelet Volume

Mean platelet volume in patients with systemic lupus erythematosus

2014 ◽  
Vol 35 (2) ◽  
pp. 547-548
Author(s):  
Ilknur Balta ◽  
Sevket Balta ◽  
Mustafa Aparci ◽  
Sait Demirkol ◽  
Cengiz Ozturk
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Mean Platelet Volume ◽  
Systemic Lupus ◽  
Platelet Volume

Is Mean Platelet Volume Related to Disease Activity in Systemic Lupus Erythematosus?

2021 ◽  
Author(s):  
Hulya Uzkeser ◽  
Havva Keskin ◽  
Sema Haliloglu ◽  
Yasemin Cayir ◽  
Yasar Karaaslan ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Disease Activity ◽  
Lupus Erythematosus ◽  
Mean Platelet Volume ◽  
Systemic Lupus ◽  
Platelet Volume
Sign in / Sign up

Export Citation Format

Share Document