Mean platelet volume as a surrogate marker of disease activity in systemic lupus erythematosus

Background Platelets are heterogeneous in size, density, metabolic, functional, and biochemical properties. Mean platelet volume (MPV) is a measure of the average size of platelet in a blood sample. Aim We aimed to evaluate the mean platelet volume as a marker for disease activity in children with systemic lupus erythematosus. Materials and Methods This was a prospective case-control study, which included 50 patients with SLE and 50 age and sex, matched healthy controls. All subjects were subjected to history taking, physical examination and laboratory parameters in active and remission phases of the diseases. Results The MPV value in the SLE group was significantly higher than control group (9.6 ± 1.3 fL, 9.1 ± 0.57 fL, respectively, p = 0.04). There was a significant increase of weight, blood pressure, urea, creatinine, proteinuria, CRP, ESR, cholestrol, MPV values, SLEDAI-2K scores and significant decrease of HB, albumin, C3, mean platelet volume (MPC) in the active stage than in the remission stage. There was a significant negative correlation between MPV and MPC in active stage of the disease but the correlation was insignificant in remission stage. Conclusion MPV increased in active phase of patients with SLE and can be an easy, rapid, inexpensive and simple method to assess disease activity in children with SLE.

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Reply to the letter “Mean platelet volume as a surrogate marker of inflammation in systemic lupus erythematosus”

Clinical Rheumatology ◽

10.1007/s10067-014-2591-5 ◽

2014 ◽

Vol 33 (11) ◽

pp. 1693-1693

Author(s):

Sevgi Yavuz ◽

Aydın Ece

Keyword(s):

Systemic Lupus Erythematosus ◽

Lupus Erythematosus ◽

Mean Platelet Volume ◽

Surrogate Marker ◽

Systemic Lupus ◽

Platelet Volume

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Low Intra-Individual Variation in Mean Platelet Volume Over Time in Systemic Lupus Erythematosus

Frontiers in Medicine ◽

10.3389/fmed.2021.638750 ◽

2021 ◽

Vol 8 ◽

Author(s):

Lina Wirestam ◽

Birgitta Gullstrand ◽

Andreas Jern ◽

Andreas Jönsen ◽

Petrus Linge ◽

...

Keyword(s):

Systemic Lupus Erythematosus ◽

Disease Activity ◽

Lupus Erythematosus ◽

Mean Platelet Volume ◽

Reference Interval ◽

Systemic Lupus ◽

Platelet Volume ◽

Cross Sectional ◽

Underlying Mechanisms ◽

Over Time

Platelets have recently emerged as important immune modulators in systemic lupus erythematosus (SLE), in addition to their role in thrombosis and cardiovascular disease. However, studies investigating mean platelet volume (MPV) in SLE are often scarce, conflicting and cross-sectional. In this study, MPV was measured in clinical routine throughout a defined time-period to quantify both individual MPV fluctuations and investigate if such variations are associated with disease activity and clinical phenotypes of SLE. Of our 212 patients, 34 patients had only one MPV value reported with the remaining 178 patients having between 2 and 19 visits with recorded MPV values. The intra-individual MPV variation was low, with a median variation of 0.7 fL. This was further supported by the finding that 84% of patients stayed within their reference interval category (i.e., small, normal or large) over time. In our cohort, no correlation between disease activity and MPV neither cross-sectionally nor longitudinally was found. Mean platelet volume values were significantly smaller in SLE patients (mean 10.5 fL) compared to controls (mean 10.8 fL), p < 0.0001. Based on the reference interval, 2.4% (n = 5) of patients had large-sized platelets, 84.4% (n = 179) had normal-sized and 13.2% (n = 28) had small-sized. A larger proportion (85.7%) of patients with small-sized platelets met the anti-dsDNA criterion (ACR10b; p = 0.003) compared to patients with normal and large (57.6%) sized platelets. In conclusion, the intra-individual MPV variation was of low magnitude and fluctuations in disease activity did not have any significant impact on MPV longitudinally. This lack of variability in MPV over time indicates that measuring MPV at any time-point is sufficient. Further studies are warranted to evaluate MPV as a possible biomarker in SLE, as well as to determine the underlying mechanisms influencing platelet size in SLE.

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