Maximum standardized uptake value change rate before and after neoadjuvant chemotherapy can predict early recurrence in patients with locally advanced esophageal cancer: a multi-institutional cohort study of 220 patients in Japan

Esophagus ◽  
2022 ◽  
Author(s):  
Kentaro Murakami ◽  
Naoya Yoshida ◽  
Yusuke Taniyama ◽  
Kozue Takahashi ◽  
Takeshi Toyozumi ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Locally Advanced ◽  
Standardized Uptake Value ◽  
Early Recurrence ◽  
Value Change ◽  
Advanced Esophageal Cancer ◽  
Change Rate ◽  
Maximum Standardized Uptake Value ◽  
Before And After ◽  
Locally Advanced Esophageal Cancer

Prognostic value of 18F-FDG PET/CT metabolic tumor volume for complete pathologic response and clinical outcomes after neoadjuvant chemoradiation therapy for locally advanced esophageal cancer.

2016 ◽  
Vol 34 (4_suppl) ◽  
pp. 150-150
Author(s):  
Puja Venkat ◽  
Jasmine A Oliver ◽  
Will Jin ◽  
Joshua Dault ◽  
Jessica M. Frakes ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Prognostic Value ◽  
Tumor Volume ◽  
Locally Advanced ◽  
Standardized Uptake Value ◽  
Metabolic Tumor Volume ◽  
Neoadjuvant Chemoradiation ◽  
Advanced Esophageal Cancer ◽  
Pet Ct ◽  
Locally Advanced Esophageal Cancer

150 Background: The prognostic value of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) has not yet been defined in locally advanced esophageal cancer (LAEC). This study aims to elucidate the prognostic role of PET/CT for patients treated with neoadjuvant chemoradiation (CRT) followed by esophagectomy. Methods: We retrospectively evaluated patients with LAEC treated from 2006 to 2014 with neoadjuvant CRT followed by esophagectomy. 86 patients had pre-CRT and post CRT PET/CT scans performed at our institution. These scans were imported into an image analysis program. PET parameters maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), mean standardized uptake value (SUVmean), and peak standardized uptake value (SUVpeak) were recorded for both pre-CRT and post-CRT scans. MTV was defined using a previously described liver method. The correlation of these parameters with pathologic complete response (pCR) and clinical outcomes was analyzed using binomial logistic regression and cox regression. Results: Pre-CRT MTV < 33.6 (median value) was significantly predictive of pCR (p = 0.019, OR = 3.064). An ROC curve was produced to determine a binary cutoff of 35.8, yielding a higher specificity (62.3% vs. 59%) and the same sensitivity (72.7%), increasing the significance to p = 0.010, OR = 3.378. The ratio of postMTV/preMTV (MTVr) was calculated. MTVr > 0.2857 (median value) was significantly predictive of distant metastasis (DM) after esophagectomy (p = 0.018, OR = 3.680). An ROC curve was produced to determine a binary cutoff of 0.301, which increased specificity from 57.1% to 60.3%, and maintained the same sensitivity at 81.3%, increasing the significance to p = 0.014, OR = 3.815. SUVmax, mean and peak were not predictive. Conclusions: Pre CRT MTV was predictive of pCR and MTVr was predictive of DM. Our data suggests that MTV is superior to SUVmax, mean and peak in predicting for response to treatment in LAEC. Further study is needed to determine if Pre CRT MTV and change in MTV can help define which patients will most benefit from esophagectomy and/ or adjuvant chemotherapy.

Chemoradiotherapy Before and After Surgery for Locally Advanced Esophageal Cancer: A SEER-Medicare Analysis

2013 ◽  
Vol 20 (12) ◽  
pp. 3999-4007 ◽  
Author(s):  
Julian C. Hong ◽  
James D. Murphy ◽  
Samuel J. Wang ◽  
Albert C. Koong ◽  
Daniel T. Chang
Keyword(s):  
Esophageal Cancer ◽  
Locally Advanced ◽  
Advanced Esophageal Cancer ◽  
Before And After ◽  
Locally Advanced Esophageal Cancer

Factors associated with local-regional failure after definitive chemoradiation for locally advanced esophageal cancer.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e14669-e14669
Author(s):  
Arya Amini ◽  
James Welsh ◽  
Pamela Allen ◽  
Lianchun Xiao ◽  
Akihiro Suzuki ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Radiation Treatment ◽  
Locally Advanced ◽  
Significant Proportion ◽  
Standardized Uptake Value ◽  
Disease Recurrence ◽  
Post Treatment ◽  
Advanced Esophageal Cancer ◽  
Definitive Chemoradiation ◽  
Locally Advanced Esophageal Cancer

e14669 Background: Esophageal cancer is often treated with a trimodality approach (chemotherapy and radiation followed by surgery). However a significant proportion of such patients achieve a clinical complete response (cCR) following chemoradiation alone. We retrospectively analyzed patients who reached cCR after definitive chemoradiation for locally advanced esophageal cancer to identify clinical predictors of local disease recurrence. Methods: We identified 141 patients who obtained initial cCR after definitive chemoradiation for esophageal cancer from January 2002 through January 2009. The initial response to treatment was assessed by endoscopic evaluation and biopsy results, with cCR defined as having no evidence of disease present. Patterns of failure were categorized as in-field (within the planned treatment volume [PTV]), outside the radiation treatment field, or both. Results: At a median follow-up of 22 months (range 6-87 months), 77 patients (55%) had experienced disease recurrence. Most first failures (32, or 23%) were outside the radiation field, followed by 30 (21%) within the field and 15 (11%) were both. In multivariate analysis, in-field failure after cCR was associated with a post-treatment standardized uptake value (SUV) on positron emission tomography of >3.5 (odds ratio [OR] 4.93, p=0.022), squamous histology (OR 0.07, p=0.010), and borderline for T3/T4 disease (OR 10.25, p=0.055). All failures, in-field and out-of-field, correlated with T3/T4 disease (OR 11.61, p=0.015), N1 disease (OR 5.07, p=0.010), pretreatment SUV >10 (OR 4.00, p=0.048), and post-treatment SUV >3.5 (OR 3.59, p=0.052). Conclusions: Clinical characteristics can be used to predict failure patterns after definitive chemoradiation. Such risk-assessment strategies can help individualize therapy.

PO-1070: Effect of surgery in locally advanced esophageal cancer after chemoradiotherapy

2020 ◽  
Vol 152 ◽  
pp. S568
Author(s):  
I. Alda Bravo ◽  
S. Fernandez Alonso ◽  
M. Alarza Cano ◽  
M.Á. Pérez-Escutia ◽  
R. D'Ambrossi ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Locally Advanced ◽  
Advanced Esophageal Cancer ◽  
Locally Advanced Esophageal Cancer
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