Optical Metabolic Imaging for Assessment of Radiation-Induced Injury to Rat Kidney and Mitigation by Lisinopril

2019 ◽  
Vol 47 (7) ◽  
pp. 1564-1574 ◽  
Author(s):  
Shima Mehrvar ◽  
Mette Funding la Cour ◽  
Meetha Medhora ◽  
Amadou K. S. Camara ◽  
Mahsa Ranji
Keyword(s):  
Rat Kidney ◽  
Metabolic Imaging ◽  
Radiation Induced

scholarly journals Anatomical, functional and metabolic imaging of radiation-induced lung injury using hyperpolarized MRI

2014 ◽  
Vol 27 (12) ◽  
pp. 1515-1524 ◽  
Author(s):  
Giles Santyr ◽  
Matthew Fox ◽  
Kundan Thind ◽  
Elaine Hegarty ◽  
Alexei Ouriadov ◽  
...  
Keyword(s):  
Lung Injury ◽  
Metabolic Imaging ◽  
Radiation Induced ◽  
Hyperpolarized Mri

In vivo Detection of Radiation-induced Tissue Alterations by Hyperpolarized 13C Metabolic Imaging

2009 ◽  
Vol 75 (3) ◽  
pp. S48-S49
Author(s):  
L. Senadheera ◽  
D. Mayer ◽  
M.M. Darpolor ◽  
Y. Yen ◽  
D.M. Spielman ◽  
...  
Keyword(s):  
Metabolic Imaging ◽  
Hyperpolarized 13C ◽  
In Vivo Detection ◽  
Radiation Induced ◽  
Tissue Alterations

Optical cryoimaging for assessment of radiation-induced injury to rat kidney metabolic state

2018 ◽  
Author(s):  
Shima Mehrvar ◽  
Mette Funding la Cour ◽  
Mahsa Ranji ◽  
Amadou K. S. Camara ◽  
Meetha Medhora
Keyword(s):  
Rat Kidney ◽  
Metabolic State ◽  
Radiation Induced

TH-D-304A-05: Novel Hyperpolarized C-13 Metabolic Imaging Technique to Monitor Radiation-Induced Tissue Damage in Vivo at Moderate Radiation Doses

2009 ◽  
Vol 36 (6Part28) ◽  
pp. 2817-2817
Author(s):  
L Senadheera ◽  
D Mayer ◽  
M Darpolor ◽  
Y Yen ◽  
R Luong ◽  
...  
Keyword(s):  
Tissue Damage ◽  
Imaging Technique ◽  
Metabolic Imaging ◽  
Radiation Doses ◽  
Radiation Induced

Expression and Localization of the Retinoblastoma Gene during Radiation-Induced Apoptosis in Neonatal Rat Kidney

1997 ◽  
Vol 235 (2) ◽  
pp. 354-361 ◽  
Author(s):  
G.C. Gobé ◽  
J. Halliday ◽  
I.S. Dunn ◽  
B.V. Harmon ◽  
E. Schoch ◽  
...  
Keyword(s):  
Rat Kidney ◽  
Neonatal Rat ◽  
Retinoblastoma Gene ◽  
Radiation Induced ◽  
Induced Apoptosis

scholarly journals Molecular controls of radiation-induced apoptosis in the neonatal rat kidney

1999 ◽  
Vol 56 (4) ◽  
pp. 1305-1309 ◽  
Author(s):  
Glenda Gobé ◽  
Estelle Schoch ◽  
Jennifer Leighton
Keyword(s):  
Rat Kidney ◽  
Neonatal Rat ◽  
Radiation Induced ◽  
Induced Apoptosis

Regional release of cyclooxygenase products after radiation exposure of the rat

1986 ◽  
Vol 61 (4) ◽  
pp. 1264-1269 ◽  
Author(s):  
M. J. Schneidkraut ◽  
P. A. Kot ◽  
P. W. Ramwell ◽  
J. C. Rose
Keyword(s):  
Prostaglandin E2 ◽  
Gamma Irradiation ◽  
Radiation Exposure ◽  
Excretion Rate ◽  
Rat Kidney ◽  
Product Release ◽  
Perfused Rat Kidney ◽  
Radiation Induced ◽  
Arachidonate Metabolite

The present study evaluated the regional release of cyclooxygenase products 4 h following 20 Gy gamma irradiation. Thoracic shielding reduced the radiation-induced increase in immunoreactive thromboxane B2 (iTxB2) excretion to control levels while abdominal shielding partially attenuated the altered excretion of this cyclooxygenase product. To assess the role the kidneys play in the radiation-induced increase in iTxB2 excretion, an in situ isolated perfused rat kidney model was developed. The excretion rate of iTxB2 from irradiated isolated perfused kidneys was not significantly different from sham-irradiated perfused kidneys. Radiation exposure did alter renal cyclooxygenase product release in that the excretion of immunoreactive prostaglandin E2 (iPG2) and immunoreactive 6-keto-PGF1 alpha was significantly increased (P less than 0.05) in irradiated isolated perfused kidneys. These data show that radiation-induced increases in iTxB2 excretion are primarily due to altered extrarenal synthesis and/or metabolism of this arachidonate metabolite.

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