Effects of Sodium Acetate and Residual Aluminum on the Hydrogenation Rate, Optical Yield and Catalyst Durability for the Enantio-Differentiating Hydrogenation of Methyl Acetoacetate Over Tartaric Acid-Modified Raney Nickel Catalysts

2008 ◽  
Vol 128 (1-2) ◽  
pp. 227-234 ◽  
Author(s):  
Shunli Cai ◽  
Kun Ma ◽  
Hangning Chen ◽  
Yunfeng Zheng ◽  
Jian Jiang ◽  
...  
Keyword(s):  
Tartaric Acid ◽  
Raney Nickel ◽  
Sodium Acetate ◽  
Nickel Catalysts ◽  
Optical Yield ◽  
Hydrogenation Rate ◽  
Methyl Acetoacetate ◽  
Residual Aluminum ◽  
Catalyst Durability

Highly Efficient Enantio-selective Hydrogenation of Methyl Acetoacetate over an Improved Tartaric Acid-modified Raney Nickel Catalyst

2006 ◽  
Vol 35 (8) ◽  
pp. 910-911 ◽  
Author(s):  
Hangning Chen ◽  
Rong Li ◽  
Huanling Wang ◽  
Liang Yin ◽  
Fushan Wang ◽  
...  
Keyword(s):  
Tartaric Acid ◽  
Nickel Catalyst ◽  
Raney Nickel ◽  
Selective Hydrogenation ◽  
Methyl Acetoacetate ◽  
Raney Nickel Catalyst ◽  
Highly Efficient

In situ Chiral Modification of Nickel Catalysts for Enantioselective Hydrogenation of Methyl Acetoacetate

2005 ◽  
Vol 70 (10) ◽  
pp. 1642-1652 ◽  
Author(s):  
Lukáš Bartek ◽  
Petr Klusoň ◽  
Libor Červený
Keyword(s):  
Raney Nickel ◽  
Asymmetric Hydrogenation ◽  
Enantioselective Hydrogenation ◽  
Nickel Catalysts ◽  
Methyl Acetoacetate ◽  
Repeated Use ◽  
Series Of Experiments ◽  
Chiral Modification ◽  
Characteristic Features

Chiral modifications of SiO2-supported and Raney nickel catalysts were studied. The catalysts were employed in asymmetric hydrogenation of methyl acetoacetate (MAA) to (R)- and (S)-enantiomers of methyl 3-hydroxybutanoate. The effects of modification parameters such as type and concentration of modifier; presence of a co-modifier and other additives, pH of modification solution on the enantioselectivity of MAA hydrogenation were discussed. Characteristic features of the in situ modification of Ni/SiO2 were also evaluated and the results obtained were compared with the conventional (premodification) approach. Parameters for the conventional and in situ methods were optimised in a series of experiments for both types of catalysts. The in situ modified Ni/SiO2 was found specifically suitable for repeated use due to virtually no decrease in selectivity and activity.

Sign in / Sign up

Export Citation Format

Share Document