A simple and highly efficient protocol for the one-pot synthesis of novel benzodiazepines, which fused tricyclic or tetracyclic systems containing aryl, carboxyl, ester and acyl groups, was developed. Libraries of 40 new compounds were successfully synthesized via three-component or domino reactions by using a mild catalyst (γ-Fe2O3@SiO2/CeCl3) in good to excellent yields (82–97%).
A method for construction of three classes of densely functionalized dispirocyclopentaneoxindoles with multiple chiral stereocenters is developed using base promoted self-domino and domino reactions with/without the presence of nucleophilic solvents.