scholarly journals Mesenteric Lymph Duct Ligation Alleviates Acute Lung Injury Caused by Severe Acute Pancreatitis Through Inhibition of High Mobility Group Box 1-Induced Inflammation in Rats

2021 ◽  
Author(s):  
Yishuang Tang ◽  
Jing Kong ◽  
Bingduo Zhou ◽  
Xiaosu Wang ◽  
Xiaowen Liu ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Severe Acute Pancreatitis ◽  
High Mobility ◽  
High Mobility Group ◽  
Mesenteric Lymph ◽  
Duct Ligation ◽  
Lymph Duct

scholarly journals Calycosin attenuates severe acute pancreatitis-associated acute lung injury by curtailing high mobility group box 1 - induced inflammation

2021 ◽  
Vol 27 (44) ◽  
pp. 7669-7686
Author(s):  
Chang-Ju Zhu ◽  
Wan-Guang Yang ◽  
De-Jian Li ◽  
Yao-Dong Song ◽  
San-Yang Chen ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Severe Acute Pancreatitis ◽  
High Mobility ◽  
High Mobility Group

scholarly journals A monoclonal anti-interleukin 8 antibody (WS-4) inhibits cytokine response and acute lung injury in experimental severe acute necrotising pancreatitis in rabbits

Gut ◽  
1998 ◽  
Vol 43 (2) ◽  
pp. 232-239 ◽  
Author(s):  
M O Osman ◽  
J U Kristensen ◽  
N O Jacobsen ◽  
S B Lausten ◽  
B Deleuran ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Severe Acute Pancreatitis ◽  
Pancreatic Necrosis ◽  
Interleukin 8 ◽  
Systemic Complications ◽  
Duct Ligation ◽  
Tnf Α

Background—Interleukin 8 (IL-8) has recently been proposed to have an important role in mediating the development of the systemic sequelae associated with severe acute pancreatitis.Aims—To define the role of IL-8 in acute pancreatitis by neutralising its effects with a monoclonal anti-IL-8 antibody (WS-4), in a rabbit model of severe acute pancreatitis.Methods—Acute pancreatitis was induced by retrograde injection of 5% chenodeoxycholic acid into the pancreatic duct and duct ligation. Twenty rabbits were divided equally into two groups: acute pancreatitis controls received physiological saline and the treated group received WS-4, 30 minutes before induction of acute pancreatitis.Results—Pretreatment of animals with WS-4 resulted in significant down regulation of serum IL-8 and tumour necrosis factor α (TNF-α) from three to six hours after induction of acute pancreatitis (p=0.011 and 0.047 for IL-8 and 0.033 and 0.022 for TNF-α, respectively). In addition, a significant reduction in the CD11b and CD18 positive cells and the amount of interstitial neutrophil infiltration in the lungs from WS-4 treated animals was seen. In contrast, WS-4 did not alter the amount of pancreatic necrosis and the serum concentrations of amylase, lipase, calcium, and glucose.Conclusion—WS-4 cannot change the amount of pancreatic necrosis induced by injection of 5% bile acid, but does reduce the acute lung injury, presumably through inhibition of circulating IL-8 and TNF-α, and CD11b/CD18 in lung tissue. Therefore, a role of IL-8 in the progression of acute pancreatitis and the development of its systemic complications is suggested.

scholarly journals High-Mobility Group Box 1 (HMGB1) and Autophagy in Acute Lung Injury (ALI): A Review

2019 ◽  
Vol 25 ◽  
pp. 1828-1837 ◽  
Author(s):  
Lihua Qu ◽  
Chao Chen ◽  
YangYe Chen ◽  
Yi Li ◽  
Fang Tang ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
High Mobility ◽  
High Mobility Group

The Effect of Experimental Diabetes on High Mobility Group Box 1 Protein Expression in Endotoxin-Induced Acute Lung Injury

2011 ◽  
Vol 168 (1) ◽  
pp. 111-118 ◽  
Author(s):  
Satoshi Hagiwara ◽  
Hideo Iwasaka ◽  
Chihiro Shingu ◽  
Shigekiyo Matumoto ◽  
Akira Hasegawa ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Protein Expression ◽  
Experimental Diabetes ◽  
High Mobility ◽  
High Mobility Group

scholarly journals Mesenteric Lymph Duct Ligation Provides Long Term Protection Against Hemorrhagic Shock-induced Lung Injury

Shock ◽  
2000 ◽  
Vol 13 (5) ◽  
pp. 10A-11A ◽  
Author(s):  
J Sambol ◽  
D Xu ◽  
C Adams ◽  
E Deitch
Keyword(s):  
Lung Injury ◽  
Hemorrhagic Shock ◽  
Mesenteric Lymph ◽  
Duct Ligation ◽  
Lymph Duct

scholarly journals Downregulation of high mobility group box 1 attenuates the severity of acute lung injury in endotoxemic mice

2015 ◽  
Vol 11 (6) ◽  
pp. 4513-4517 ◽  
Author(s):  
XIAOJUAN ZHANG ◽  
ZHENGGANG LUAN ◽  
YINGJIAN LIANG ◽  
YINA LIU ◽  
XIAOCHUN MA
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
High Mobility ◽  
High Mobility Group

Increase of High-Mobility Group Box Chromosomal Protein 1 in Blood and Injured Organs in Experimental Severe Acute Pancreatitis

Pancreas ◽  
2007 ◽  
Vol 34 (4) ◽  
pp. 487-488 ◽  
Author(s):  
Takeo Yasuda ◽  
Takashi Ueda ◽  
Makoto Shinzeki ◽  
Hidehiro Sawa ◽  
Takahiro Nakajima ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Severe Acute Pancreatitis ◽  
High Mobility ◽  
High Mobility Group ◽  
Chromosomal Protein

Effects of penehyclidine hydrochloride on severe acute pancreatitis-associated acute lung injury in rats

2018 ◽  
Vol 97 ◽  
pp. 1689-1693 ◽  
Author(s):  
Rongtao Zhu ◽  
Yipu Zhao ◽  
Xiaobo Li ◽  
Tao Bai ◽  
Shuai Wang ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Severe Acute Pancreatitis ◽  
Penehyclidine Hydrochloride
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