Interleukin-4 -589C/T Polymorphism is Associated with Increased Pediatric Asthma Risk: A Meta-Analysis

Objective: The correlation of the angiotensin-converting enzyme ( ACE) insertion/deletion (I/D) polymorphism with pediatric asthma risk was assessed in this meta-analysis. Methods: PubMed, Web of Science, Embase and CNKI databases were systematically searched for relevant literature, followed by application of odds ratios (OR) along with 95% confidence interval (CI) for determining the strength of relationship. Results: Seven articles with 802 cases and 632 controls fulfilled the inclusion criteria. As a result, the ACE I/D polymorphism was related to elevated pediatric asthma risk (D vs I: OR = 1.87, 95% CI = 1.59–2.20; dominant model: OR =1.53, 95% CI = 1.28–1.81; recessive model: OR =1.54, 95% CI = 1.28–1.85; DD vs II: OR =2.95, 95% CI = 2.19–3.98; DI vs II: OR = 0.96, 95% CI = 0.78–1.19). Subgroup analysis stratified by race revealed significant interrelation in Asians. Conclusion: This meta-analysis demonstrated that the ACE I/D polymorphism might be related to the risk of pediatric asthma.

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Interleukin-4 gene polymorphism (C33T) and the risk of the asthma: a meta-analysis based on 24 publications

BMC Medical Genetics ◽

10.1186/s12881-020-01169-w ◽

2020 ◽

Vol 21 (1) ◽

Author(s):

Danyal Imani ◽

Mohammad Masoud Eslami ◽

Gholamreza Anani-Sarab ◽

Mansur Aliyu ◽

Bahman Razi ◽

...

Keyword(s):

Risk Factor ◽

Subgroup Analysis ◽

Meta Analysis ◽

Age Groups ◽

Positive Association ◽

Interleukin 4 ◽

Reliable Estimate ◽

Significant Positive Association ◽

Asthma Risk ◽

Allelic Model

Abstract Background Previous studies evaluated the association of IL-4 C33T polymorphism and risk of bronchial asthma but failed to establish a consistent conclusive association. In the present meta-analysis, we intend to define a more reliable estimate of the association in the presence of filling published literature. Methods An exhaustive search in Web of Science, Scopus, and PubMed databases was performed to identify all relevant publications before September 2020, and 24 publications (28 studies) with 6587 cases and 8408 controls were included in final analysis. The association between polymorphism and risk of asthma were measured by Odd ratios (ORs) and 95% confidence intervals (CIs). Moreover, Cochran’s Q and the I2 statistics were used to evaluate the degree of heterogeneity between studies. Results In the overall study populations, a significant positive association was detected under all genotype models and announced the IL-4 C33T polymorphism as a potential risk factor in the pathogenesis of asthma. In the subgroup analysis by age, a significant association between IL-4 C33T polymorphism and risk of asthma in different age groups was identified in allelic model, which highlighted the predisposing role of the T allele for the asthma risk in all three age groups. Furthermore, the results of subgroup analysis by continent were heterogenous. Accordingly, IL-4 C33T polymorphism was a risk factor in Europeans (all models except heterozygote comparison), Americans (all models except recessive and homozygote comparison) and Asians (just recessive and allelic model). Finally, the ethnicity-specific analysis disclosed a significant association between IL-4 C33T polymorphism and asthma risk in Caucasians (all genotype models except heterozygote comparison), while this association was not significant in African-Americans. Conclusions This study suggests that IL-4 C33T polymorphism potentially acts as a risk factor for asthma in different ethnicities and age groups.

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Association between Interleukin-4 Receptor α Chain (IL4RA) I50V and Q551R Polymorphisms and Asthma Risk: An Update Meta-Analysis

PLoS ONE ◽

10.1371/journal.pone.0069120 ◽

2013 ◽

Vol 8 (7) ◽

pp. e69120 ◽

Cited By ~ 11

Author(s):

Wei Nie ◽

Yuansheng Zang ◽

Jiquan Chen ◽

Qingyu Xiu

Keyword(s):

Meta Analysis ◽

Interleukin 4 ◽

Asthma Risk ◽

Α Chain ◽

Interleukin 4 Receptor

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Interleukin-4 gene polymorphism (C33T) and the risk of the asthma: A meta-analysis based on 24 studies

10.21203/rs.2.20557/v3 ◽

2020 ◽

Author(s):

Danyal Imani ◽

Mohammad Masoud Eslami ◽

Gholamreza Anani Sarab ◽

Mansur Aliyu ◽

Bahman Razi ◽

...

Keyword(s):

Risk Factor ◽

Subgroup Analysis ◽

Meta Analysis ◽

Age Groups ◽

Positive Association ◽

Interleukin 4 ◽

Reliable Estimate ◽

Significant Positive Association ◽

Asthma Risk ◽

Allelic Model

Abstract Background: Previous studies evaluated the association of IL-4 C33T polymorphism and risk of bronchial asthma but failed to establish a consistent conclusive association. In the present meta-analysis, we intend to define a more reliable estimate of the association in the presence of filling published literature.Methods: An exhaustive search in Web of Science, Scopus, and PubMed databases was performed to identify all relevant publications before September 2020, and 24 publications (28 studies) with 6587 cases and 8408 controls were included in final analysis. The association between polymorphism and risk of asthma were measured by Odd ratios (ORs) and 95% confidence intervals (CIs). Moreover, Cochran's Q and the I2 statistics were used to evaluate the degree of heterogeneity between studiesResults: In the overall study populations, a significant positive association was detected under all genotype models and announced the IL-4 C33T polymorphism as a potential risk factor in the pathogenesis of asthma. In the subgroup analysis by age, a significant association between IL-4 C33T polymorphism and risk of asthma in different age groups was identified in allelic model, which highlighted the predisposing role of the T allele for the asthma risk in all three age groups. Furthermore, the results of subgroup analysis by continent were heterogenous. Accordingly, IL-4 C33T polymorphism was a risk factor in Europeans (all models except heterozygote comparison), Americans (all models except recessive and homozygote comparison) and Asians (just recessive and allelic model). Finally, the ethnicity-specific analysis disclosed a significant association between IL-4 C33T polymorphism and asthma risk in Caucasians (all genotype models except heterozygote comparison), while this association was not significant in African-Americans.Conclusions: This study suggests that IL-4 C33T polymorphism potentially acts as a risk factor for asthma in different ethnicities and age groups.

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Interleukin-4 gene polymorphism (C33T) and the risk of the asthma: A meta-analysis based on 24 studies

10.21203/rs.2.20557/v2 ◽

2020 ◽

Author(s):

Danyal Imani ◽

Mohammad Masoud Eslami ◽

Gholamreza Anani Sarab ◽

Mansur Aliyu ◽

Bahman Razi ◽

...

Keyword(s):

Risk Factor ◽

Subgroup Analysis ◽

Meta Analysis ◽

Age Groups ◽

Positive Association ◽

Interleukin 4 ◽

Reliable Estimate ◽

Significant Positive Association ◽

Asthma Risk ◽

Allelic Model

Abstract Background: Previous studies evaluated the association of IL-4 C33T polymorphism and risk of bronchial asthma but failed to establish a consistent conclusive association. In the present meta-analysis, we intend to define a more reliable estimate of the association in the presence of filling published literature.Methods: An exhaustive search in web of science, Scopus, and PubMed databases was performed to identify all relevant publications before September 2020, and 24 publications (28 studies) with 6587 cases and 8408 controls were included in final analysis. The association between polymorphism and risk of asthma were measured by Odd ratios (ORs) and 95% confidence intervals (CIs). Moreover, Cochran Q and the I2 statistics were used to evaluate the degree of heterogeneity between studiesResults: In the overall study populations, a significant positive association was detected under all genotype models and announced the IL-4 C33T polymorphism as a potential risk factor in the pathogenesis of asthma. In the subgroup analysis by age, a significant association between IL-4 C33T polymorphism and risk of asthma in different age groups was identified in allelic model, which highlighted the predisposing role of the T allele for the asthma risk in all three age groups. Furthermore, the results of subgroup analysis by continent were heterogenous. Accordingly, IL-4 C33T polymorphism was a risk factor in Europeans (all models except heterozygote compression), Americans (all models except recessive and homozygote compression) and Asians (just recessive and allelic model). Finally, the ethnicity-specific analysis disclosed a significant association between IL-4 C33T polymorphism and asthma risk in Caucasians (all genotype models except heterozygote comparison), while this association was not significant in American-Africans.Conclusions: This study suggests that IL-4 C33T polymorphism potentially acts as a risk factor for asthma in different ethnicities and age groups.

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Interleukin-4 gene polymorphism (C33T) and the risk of the asthma: A meta-analysis based on 24 studies

10.21203/rs.2.20557/v1 ◽

2020 ◽

Author(s):

Danyal Imani ◽

Mohammad Masoud Eslami ◽

Gholamreza Anani Sarab ◽

Mansur Aliyu ◽

Bahman Razi ◽

...

Keyword(s):

Risk Factor ◽

Meta Analysis ◽

Age Groups ◽

Asian Population ◽

Final Analysis ◽

Recessive Model ◽

Interleukin 4 ◽

Reliable Estimate ◽

Asthma Risk

Abstract Background Previous studies evaluate an association of IL-4 C33T polymorphism and risk of bronchial asthma but failed to establish a consistent conclusive association between the two. In the present meta-analysis, we intend to define a more reliable estimate of the association in the presence of filling published literature.Methods An exhaustive search in web of science, Scopus, and PubMed databases was performed to identify all relevant publications before November 2019, and 24 studies with 6587 cases and 8408 controls were included in final analysis. The association between polymorphism and risk of asthma were measured by Odd ratios (ORs) and 95% confidence intervals (CIs). Moreover, Cochran Q and the I2 statistics were used to evaluated the degree of heterogeneity between studiesResults In the overall study populations, the result illustrated that IL-4 C33T polymorphism was a risk factor in the pathogenesis of asthma. In the subgroup analysis by age, a significant association between IL-4 SNP (C33T) and risk of asthma in different age groups was identified in allelic model, which highlighted the predisposing role of the T allele for the asthma risk in all three age groups. In the Asian population, there was a significant association between IL-4 SNP (C33T) and risk of asthma under recessive and allelic models. Finally, there was a significant association between IL-4 SNP (C33T) and asthma risk in Caucasian under recessive model and allelic model.Conclusions This study suggests that IL-4 C33T single nucleotide polymorphism potentially acts as a risk factor for asthma in different ethnicities and age groups.

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