significant positive association
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2022 ◽  
Vol 20 (1) ◽  
Author(s):  
Elham Kalantari ◽  
Tahereh Taheri ◽  
Saba Fata ◽  
Maryam Abolhasani ◽  
Mitra Mehrazma ◽  
...  

Abstract Background The crucial oncogenic role of cancer stem cells (CSCs) in tumor maintenance, progression, drug resistance, and relapse has been clarified in different cancers, particularly in colorectal cancer (CRC). The current study was conducted to evaluate the co-expression pattern and clinical significance of epithelial cell adhesion molecules (EpCAM) and activated leukocyte cell adhesion (CD166 or ALCAM) in CRC patients. Methods This study was carried out on 458 paraffin-embedded CRC specimens by immunohistochemistry on tissue microarray (TMA) slides. Results Elevated expression of EpCAM and CD166 was observed in 61.5% (246/427) and 40.5% (164/405) of CRC cases. Our analysis showed a significant positive association of EpCAM expression with tumor size (P = 0.02), tumor stage (P = 0.007), tumor differentiate (P = 0.005), vascular (P = 0.01), neural (P = 0.01), and lymph node (P = 0.001) invasion. There were no significant differences between CD166 expression and clinicopathological parameters. Moreover, the combined analysis demonstrated a reciprocal significant correlation between EpCAM and CD166 expression (P = 0.02). Interestingly, there was a significant positive correlation between EpCAM/CD166 phenotypes expression and tumor stage (P = 0.03), tumor differentiation (P = 0.05), neural, and lymph node invasion (P =0.01). Conclusions The significant correlation of EpCAM and CD166 expression and their association with tumor progression and aggressive behavior is the reason for the suggestion of these two CSC markers as promising targets to promote novel effective targeted-therapy strategies for cancer treatment in the present study.


2022 ◽  
Vol 14 (2) ◽  
pp. 728
Author(s):  
Nguyen Hoang-Tung ◽  
Hoang Thuy Linh ◽  
Hoang Van Cuong ◽  
Phan Le Binh ◽  
Shinichi Takeda ◽  
...  

The ride-hailing service (RHS) has emerged as a major form of daily travel in many Southeast Asian cities where motorcycles are extensively used. This study aims to analyze the local context in motorcycle-based societies, which may affect the establishment of travelers’ choice set after the appearance of RHSs. In particular, it empirically compares three types of choice-set structures in the context of urban travel mode choice by estimating standard logit and nested logit models to test six hypotheses on the associations of RHS adoption with its determinants. Revealed preference data of 449 trips from both RHS users and non-RHS users were collected through a face-to-face interview-based questionnaire survey in Hanoi, Vietnam, in December 2020. The results of model estimations revealed: (1) a substitutional effect for two-wheelers but not for four-wheelers, (2) a significant positive influence of car ownership on car RHS adoption but not on motorcycle RHS adoption, (3) significantly high sensitivity to travel time of motorcycle RHS but not of car RHS, (4) a significant negative effect of traffic congestion on car RHS adoption but an insignificant one on motorcycle RHS adoption, and (5) a significant positive association of an individual’s experience in using a smartphone with car RHSs but insignificant association with motorcycle RHSs. Our findings suggest that transportation policies of RHS motorcycles should be different from those of RHS cars because of the heterogeneity in travel behaviors of RHS users between them. They also indicate that the transition from motorcycles to cars as well as the difference in service availability among different types of RHSs should be incorporated into the development of transportation policies in Southeast Asian cities.


2022 ◽  
Vol 21 (1) ◽  
Author(s):  
Ekaterina Chirikova ◽  
Robert J. McConnell ◽  
Patrick O’Kane ◽  
Vasilina Yauseyenka ◽  
Mark P. Little ◽  
...  

Abstract Background While there is a robust literature on environmental exposure to iodine-131 (131I) in childhood and adolescence and the risk of thyroid cancer and benign nodules, little is known about its effects on thyroid volume. Methods To assess the effect of 131I dose to the thyroid on the volume of the thyroid gland, we examined the data from the baseline screening of the Belarusian-American Cohort Study of residents of Belarus who were exposed to the Chernobyl fallout at ages ≤18 years. Thyroid dose estimates were based on individual thyroid activity measurements made shortly after the accident and dosimetric data from questionnaires obtained 10-15 years later at baseline screening. During baseline screening, thyroid gland volume was assessed from thyroid ultrasound measurements. The association between radiation dose and thyroid volume was modeled using linear regression where radiation dose was expressed with power terms to address non-linearity. The model was adjusted for attained age, sex, and place of residence, and their modifying effects were examined. Results The analysis was based on 10,703 subjects. We found a statistically significant positive association between radiation dose and thyroid volume (P < 0.001). Heterogeneity of association was observed by attained age (P < 0.001) with statistically significant association remaining only in the subgroup of ≥18 years at screening (P < 0.001). For this group, increase in dose from 0.0005 to 0.15 Gy was associated with a 1.27 ml (95% CI: 0.46, 2.07) increase in thyroid volume. The estimated effect did not change with increasing doses above 0.15 Gy. Conclusions This is the first study to examine the association between 131I dose to the thyroid gland and thyroid volume in a population of individuals exposed during childhood and systematically screened 10-15 years later. It provides evidence for a moderate statistically significant increase in thyroid volume among those who were ≥ 18 years at screening. Given that this effect was observed at very low doses and was restricted to a narrow dose range, further studies are necessary to better understand the effect.


2022 ◽  
pp. 026540752110646
Author(s):  
Chih-Wen Wu

Given the aging of the global population, the experience of adult children preparing to care for their aging parents is increasingly valued. In this article, I not only examined the associations between Taiwanese adult children’s attachment relationships with parents and their experience of filial anxiety but also took a psychocultural perspective to explore the mediating role of filial piety, the most representative value in the Chinese family. I collected survey data from 1305 middle-aged Taiwanese adults over 40 years old whose father or mother was alive and over 65 years old. The results from the first model for both father–child and mother–child datasets showed that secure attachment relationships with parents had a significant positive association with adults’ parental-welfare-focused filial anxiety B (FAB) but a significant negative association with their caregiver-role-focused filial anxiety A (FAA). The results from the second analysis indicated that secure attachment relationships with parents, for both father–child and mother–child datasets, had a significant positive association with adults’ endorsement of reciprocal filial piety beliefs, which significantly related to higher levels of FAB but lower levels of FAA. For both the father–child and mother–child datasets, secure attachment relationships with parents also had a significant positive association with their endorsement of authoritarian filial piety beliefs. Subsequently, their endorsement of authoritarian filial piety belief significantly related to a higher level of FAB in only the mother–child dataset. In conclusion, these findings broaden the understanding of adult children’s experience of filial anxiety that could be related to their attachment relationship with parents and their endorsement of reciprocal and authoritarian filial piety.


Author(s):  
Sebastian Duchene ◽  
Leo Featherstone ◽  
Birgitte Freiesleben de Blasio ◽  
Edward C Holmes ◽  
Jon Bohlin ◽  
...  

Abstract We explored how the duration, size and number of virus transmission clusters, defined as country-specific monophyletic groups in a SARS-CoV-2 phylogenetic tree, differed between the Nordic countries of Norway, Sweden, Denmark, Finland and Iceland. Our results suggest that although geographical connectivity, population density and openness influence the spread and the size of SARS-CoV-2 transmission clusters, the differing country-specific intervention strategies had the largest impact. We also found a significant positive association between the size and duration of transmission clusters in the Nordic countries, suggesting that the rapid deployment of contact tracing is a key response measure in reducing virus transmission.


2022 ◽  
pp. 99-115
Author(s):  
John Agyekum Addae ◽  
Emmanuel Numapau Gyamfi

Global discourse is geared towards greater accountability and regulatory oversight of banks to promote sound financial systems and charter value. The authors applied dynamic pool panel analysis to investigate the relationship between risk governance and financial performance among African global banks spanning the years 2015 to 2020. They find significant positive association between financial experts on risk committee and bank profitability. The results further reveal that risk committee activism as a proxy for risk committee effectiveness significantly increase bank profitability. Therefore, stakeholders must prioritize regular risk committee meetings and attach importance to risk committee compositions with finance experts on the majority. Additionally, this study offers policy implications for regulators and bank mangers to clearly define risk committee financial experts and minimum financial experts required to serve on the risk committee.


2021 ◽  
Vol 2 (2) ◽  
pp. 236-247
Author(s):  
Muhammad Ali Sher ◽  
Abdus Salam Khan ◽  
Zulfiqar Ali ◽  
Sultan Habibullah Khan

A genome-wide association study (GWAS) was performed using a high-density infinium 90K SNP array. We identified a total markers traits associations (MTAs) (p ?0.000) for the following plant traits; days taken to 50% heading(DH), days to 50% maturity (DM), plant height (Ph) cm, flag leaf area cm2 (FLA), tillers number per plant, spike length (SL) cm and grain yield per plant (GP) g. Most of the SNPs were identified in the A and B genome as compared to the D genome. The significant associated SNPs were mainly distributed on the chromosome 2B, 3B, 5A, and 5B. Nine SNPs on chromosome 5A, 2B and 2D were identified having pleiotropic effects The correlation analysis showed a significant positive association among SL, NT, GP. Which depicted that these traits are promising for breeding high yielding wheat cultivars. This study provided useful information of the valuable genetic loci for marker-assisted breeding. 


2021 ◽  
Vol 25 (2) ◽  
pp. 145-152
Author(s):  
Jeyaseelan Maria Michael ◽  
Marc Eric S. Reyes

Victimization via cyberbullying has become a significant mental health concern particularly among adolescents at risk of depression and other mental health issues. As the COVID-19 outbreak forced everyone to stay at home and participate in their educational, recreational, and entertainment activities online, this study investigated the relation between cyberbullying victimization and depressive symptoms among 612 college students in Tamilnadu, India. We hypothesized that experiences of cyberbullying victimization would predict depressive symptoms among the participants. Adolescents aged 18 to 19 from colleges in Tamilnadu completed an online survey composed of the Cybervictimization Questionnaire for Adolescents (CYVIC) and the Beck’s Depression Inventory-II (BDI-II). Results showed a significant positive relation between cyberbullying victimization and depression (r = 0.80, p < .001). Regression analysis revealed that cyberbullying victimization is a statistically significant predictor of depressive symptoms (r2 = 0.65). Likewise, impersonation (r = 0.70), written–verbal cyber victimization (r = 0.73), visual teasing/happy slapping (r = 0.69), and online exclusion (r = 0.67) contributed to the significant positive association between the variables. These findings can serve as a foundation for intervention programs to alleviate depressive symptoms by addressing cyberbullying experiences and conducting further research on the negative effects of cyberbullying victimization among adolescents.


2021 ◽  
Vol 2 (2) ◽  
pp. 189-198
Author(s):  
Dr Shamaila Asad ◽  
Samia Khalid ◽  
Sadaf Rehman ◽  
Maham Abdullah

Religious orientation is an attitude toward religion or religious practices or an integrated set of attitudes and beliefs. As religion emphasizes moral codes designed to instil values such as helping, caring, emotional support and empathy in humans so, the study was designed to investigate the relationship between religious orientation and pro-social behavior of young female students. The study also examines the predicting role of religious orientation in the development of prosocial behavior in young female students. The non-probability purposive sampling technique has been used with correlational research design in order to collect data. Analysis was conducted on SPSS by using sample of N=150 young female students with age ranged 20-26 years (M=23.50, SD=3.43). The results showed religious orientation had significant positive association with pro-social behavior (r=.40, p>.00) in young female students. Meanwhile, the findings revealed that religious orientation was a significant positive predictor of prosocial behavior in young female students. The study implies that such types of religious orientation will develop more awareness in youth of the present era about the development of prosocial behaviors like charity and help to the needy.


2021 ◽  
pp. 003022282110652
Author(s):  
Zülfünaz Özer ◽  
Meyreme Aksoy ◽  
Gülcan Bahcecioglu Turan

This study was conducted to find out the relationship between death anxiety and religious coping styles in patients diagnosed with COVID-19. This cross-sectional and relational study was carried out with snowball sampling technique between May 15 and June 15, 2021. It was found that the participants had a mean Death Anxiety Scale total score of 10.42 [Formula: see text], they had a mean positive religious coping sub-scale score of [Formula: see text] and a mean negative religious coping sub-scale score of 12.82 [Formula: see text]. Statistically significant positive association was found between Death Anxiety Scale and Religious Coping Questionnaire’s both positive and negative coping sub-scale scores ( p < .05). It was found that patients diagnosed with COVID-19 had high level of death anxiety and positive religious coping styles. It was also found that death anxiety levels increased in the patients as their use of positive and negative coping increased.


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