The efficacy of topical 0.05 % cyclosporine A in patients with dry eye disease associated with Sjögren’s syndrome

2014 ◽  
Vol 34 (5) ◽  
pp. 1043-1048 ◽  
Author(s):  
Hülya Devecı ◽  
Senol Kobak
Keyword(s):  
Sjögren’S Syndrome ◽  
Dry Eye ◽  
Cyclosporine A ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Sjögren‘S Syndrome

scholarly journals Dry eye disease associated with Primary Sjogren syndrome: An update

2021 ◽  
Vol 7 (2) ◽  
pp. 259-269
Author(s):  
Rajendra P Maurya ◽  
Vibha Singh ◽  
Ashish Gupta ◽  
Virendra P Singh ◽  
Amit Kumar ◽  
...  
Keyword(s):  
Sjögren’S Syndrome ◽  
Dry Eye ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Sjogren Syndrome ◽  
Primary Sjögren Syndrome ◽  
Sjögren‘S Syndrome

Primary Sjögren’s syndrome (pSS) is a chronic, multisystem autoimmune disorder, characterized by mononuclear infiltration of exocrine glands and other organs, resulting in dry eye, dry mouth and extra-glandular systemic findings. Primary Sjögren syndrome is of particular interest to ophthalmologists as it constitutes an important differential diagnosis in conditions with dry eye disease. The ocular tests are of great importance for diagnosis and monitoring of primary sjogren’s syndrome. Also a better understanding of immunological mechanisms and molecular pathways have resulted in discovery of new therapeutics for local and systemic treatment. This article illustrates an update regarding pathogenesis, diagnosis, investigative procedures and treatment options for dry eye related to Sjogren’s syndrome.

scholarly journals Prevalence of Dry Eye Disease in Connective Tissue Disorders

2021 ◽  
pp. 1-5
Author(s):  
Jigish Desai
Keyword(s):  
Connective Tissue ◽  
Sjögren’S Syndrome ◽  
Dry Eye ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Connective Tissue Disorders ◽  
Sjögren‘S Syndrome

Aim: To assess prevalence of dry eye disease (DED) and its severity in patients of Systemic lupus erythematosus (SLE) and Primary Sjogren’s syndrome in a tertiary care hospital in Gujarat. Methods: It is a Prospective cross-sectional study of 94 patients diagnosed with SLE and Sjogren’s syndrome. All patients underwent: 1. History taking 1. Visual acuity assessment using standard illuminated Snellen chart 2. Slit lamp examination with dry eye tests 3. Fundus examination The findings were recorded in the proforma and subsequent analysis was done using SSPS software. Results: DED prevalence was 51.1% overall, 42% among SLE and 66.66%in Primary Sjogren’s syndrome. Severity of DED was noted to be more in Primary sjogren’swith 33.33% having severe DED. Conclusion: DED overall prevalence in connective tissue disorders is significant, highest being in Sjogren’s. The findings highlight the severity of DED in rheumatoid arthritisgreater to when compared with other connective tissue disorders. Awareness and earlydetection of dry eye disease is of paramount to initiate appropriate treatment and reducevisual morbidity.

scholarly journals Customary practices in the monitoring of dry eye disease in Sjogren's syndrome

2018 ◽  
Vol 11 (4) ◽  
pp. 232-241 ◽  
Author(s):  
Mira Acs ◽  
Barbara Caffery ◽  
Melissa Barnett ◽  
Charles Edmonds ◽  
Larisa Johnson-Tong ◽  
...  
Keyword(s):  
Sjögren’S Syndrome ◽  
Dry Eye ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Customary Practices ◽  
Sjögren‘S Syndrome

scholarly journals Assessment of the Compliance with 0.1% Cyclosporine A in Dry-Eye Patients with Sjögren's Syndrome

2021 ◽  
Vol 62 (7) ◽  
pp. 895-903
Author(s):  
Do Hee Park ◽  
Hyung Nam Jin ◽  
Hee Su Yoon ◽  
Hyeon Jeong Yoon ◽  
Kyung-Chul Yoon
Keyword(s):  
Sjögren’S Syndrome ◽  
Dry Eye ◽  
Cyclosporine A ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Eye Drops ◽  
Eye Symptoms ◽  
Dry Eye Symptoms ◽  
Sjögren‘S Syndrome

Purpose: To evaluate the compliance with 0.1% cyclosporine A in dry eye patients with Sjögren's syndrome and identify factors affecting the compliance. Methods: This study included 67 dry eye patients with Sjögren's syndrome who had used 0.1% cyclosporine A for over 6 months. Clinical parameters including sex, age, the number of eye drops used, side effects, the use of steroid eye drops, and the visit interval were investigated. Additionally, the ocular surface disease index, tear break-up time (TBUT), Schirmer test score, and corneal fluorescein staining (CFS) score were assessed. Patients were classified into compliant and non-compliant groups, using a criterion of 50% compliance; relevant factors were evaluated accordingly. Results: Of the 67 patients, 36 (53.7%) were classified into the compliant group and 31 (46.3%) into the non-compliant group. Compared to the non-compliant group, the compliant group showed a longer TBUT (p = 0.03) and a lower CFS score (p = 0.04) at 6 months of follow-up. Altogether, 39 subjects (58.2%) experienced side effects, of which the most common was stinging pain (71.8%). In the multivariate analysis, severe dry-eye symptoms (p = 0.03), non-use of the steroid eye drops (p = 0.02), and longintervals between exam vitists (p = 0.02) were identified as factors reducing compliance. Conclusions: Factors related to a decrease in the compliance with 0.1% cyclosporine A in dry-eye patients with Sjögren's syndrome, included severe dry eye symptoms, long visit intervals, and non-use of steroid eye drops. Taking these factors into consideration may help increase patient compliance.

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