Reproducibility and repeatability of central corneal thickness measurement in healthy eyes using four different optical devices

Background: Brimonidine is a potent ocular hypotensive agent widely used in glaucoma treatment. A reduction in central corneal thickness can lead to an underestimation of intraocular pressure by Goldmann applanation tonometry and vice versa. The aim of this study is to determine whether brimonidine has an effect on central corneal thickness.Methods: 30 eyes of patients who attended the Ophthalmology OPD between the time period October 2017 and June 2018 who were newly diagnosed with normal tension glaucoma with no history of any systemic illness or not on any medication were included. Each patient underwent a complete ophthalmic evaluation including fundus examination, visual field assessment, intraocular pressure, central corneal thickness measurement by pachymetry before as well as 1 month and 6 months after starting treatment with 0.2% topical brimonidine twice daily.Results: Administration of brimonidine 0.2% resulted in an increase in central corneal thickness from 525±21 µm before starting brimonidine to 528±21 µm (p<0.05) after 1 month and 535±20 µm (p<0.001) after 6 months. It also resulted in a reduction in intraocular pressure from an initial value of 16±2 mmHg before starting brimonidine to 14±2 mmHg (p<0.05) and 13±2 mmHg (p<0.05), 1month and 6 months after starting treatment, respectively.Conclusions: The data presented in this study show that topical administration of 0.2% brimonidine twice daily results in a significant increase in central corneal thickness in patients with normal tension glaucoma.

Download Full-text

Central Corneal Thickness Measurement After Cataract Surgery

Cornea ◽

10.1097/ico.0000000000001495 ◽

2018 ◽

Vol 37 (4) ◽

pp. e19-e20 ◽

Cited By ~ 4

Author(s):

Maddalena De Bernardo ◽

Nicola Rosa

Keyword(s):

Cataract Surgery ◽

Central Corneal Thickness ◽

Corneal Thickness ◽

Thickness Measurement

Download Full-text

Comparison of central corneal thickness measurement by scanning slit topography, infrared, and ultrasound pachymetry in normal and post-LASIK eyes

International Ophthalmology ◽

10.1007/s10792-020-01475-5 ◽

2020 ◽

Vol 40 (11) ◽

pp. 2913-2921

Author(s):

Wing-cheung Ho ◽

Philip Tsze-ho Lam ◽

Thomas Yee-hang Chiu ◽

Mandy Ching-man Yim ◽

Fion Tung-ching Lau

Keyword(s):

Central Corneal Thickness ◽

Corneal Thickness ◽

Thickness Measurement ◽

Ultrasound Pachymetry

Download Full-text

Repeatability and Agreement of Central Corneal Thickness and Keratometry Measurements between Four Different Devices

Journal of Ophthalmology ◽

10.1155/2017/6181405 ◽

2017 ◽

Vol 2017 ◽

pp. 1-8 ◽

Cited By ~ 9

Author(s):

Laszlo Kiraly ◽

Jana Stange ◽

Kathleen S. Kunert ◽

Saadettin Sel

Keyword(s):

Clinical Practice ◽

Statistical Analysis ◽

Correlation Coefficient ◽

Central Corneal Thickness ◽

Corneal Thickness ◽

Intraclass Correlation ◽

Bland Altman Method ◽

Significant Difference ◽

Healthy Eyes ◽

Iolmaster 700

Background.To estimate repeatability and comparability of central corneal thickness (CCT) and keratometry measurements obtained by four different devices in healthy eyes.Methods.Fifty-five healthy eyes from 55 volunteers were enrolled in this study. CCT (IOLMaster 700, Pentacam HR, and Cirrus HD-OCT) and keratometry readings (IOLMaster 700, Pentacam HR, and iDesign) were measured. For statistical analysis, the corneal spherocylinder was converted into power vectors (J0, J45). Repeatability was assessed by intraclass correlation coefficient (ICC). Agreement of measurements between the devices was evaluated by the Bland-Altman method.Results.The analysis of repeatability of CCT data of IOLMaster 700, Pentacam HR, and Cirrus HD-OCT showed high ICCs (range 0.995 to 0.999). The comparison of CCT measurements revealed statistically significant differences between Pentacam HR versus IOLMaster 700 (p<0.0001) and Pentacam HR versus Cirrus HD-OCT (p<0.0001), respectively. There was no difference in CCT measurements between IOLMaster 700 and Cirrus HD-OCT (p=0.519). The repeatability of keratometry readings (J0 and J45) of IOLMaster 700, Pentacam HR, and iDesign was also high with ICCs ranging from 0.974 to 0.999. The Pentacam HR revealed significantly higher J0 in comparison to IOLMaster 700 (p=0.009) and iDesign (p=0.041); however, no significant difference was between IOLMaster 700 and iDesign (p=0.426). Comparison of J45 showed no significant difference between IOLMaster 700, Pentacam HR, and iDesign. These results were in accordance with Bland-Altman plots.Conclusion.In clinical practice, the devices analyzed should not be used interchangeably due to low agreement regarding CCT as well as keratometry readings.

Download Full-text