scholarly journals The effect of Fisher information matrix approximation methods in population optimal design calculations

2016 ◽  
Vol 43 (6) ◽  
pp. 609-619 ◽  
Author(s):  
Eric A. Strömberg ◽  
Joakim Nyberg ◽  
Andrew C. Hooker
Keyword(s):  
Optimal Design ◽  
Fisher Information ◽  
Fisher Information Matrix ◽  
Information Matrix ◽  
Approximation Methods ◽  
Matrix Approximation ◽  
Design Calculations ◽  
Population Optimal Design

scholarly journals Optimal design for population pk/pd models

2012 ◽  
Vol 51 (1) ◽  
pp. 115-130
Author(s):  
Sergei Leonov ◽  
Alexander Aliev
Keyword(s):  
Optimal Design ◽  
Fisher Information ◽  
Fisher Information Matrix ◽  
Information Matrix ◽  
Optimal Sampling ◽  
Design Algorithm ◽  
Sampling Schemes ◽  
Population Pk ◽  
Different Types

ABSTRACT We provide some details of the implementation of optimal design algorithm in the PkStaMp library which is intended for constructing optimal sampling schemes for pharmacokinetic (PK) and pharmacodynamic (PD) studies. We discuss different types of approximation of individual Fisher information matrix and describe a user-defined option of the library.

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