How to motivate students to do a course project in design of experiments course from a web-based virtual learning material?

Purpose The purpose of this study is to develop a practical method for training students how to conduct statistical analysis and do a course project in design of experiments (DOEs) course through the Web-based virtual catapult simulation. Design/methodology/approach A step-by-step sequential DOE process for investigating the effects of controllable factors on quality characteristic responses was presented as a guideline for conducting a DOE course project. Each team was assigned to create an innovative teaching material and work on the term report by following the recommended guidelines for designing experiments through the Web-based virtual catapult simulation. Hypothesis was defined to test whether doing a course project based on this approach would impact students’ learning outcome. Findings The Web-based virtual material was an alternative technique for interactive teaching that could improve students’ understanding and achievement in DOE course projects. There was a significant difference in student learning and understanding before and after doing on the course project through the Web-based virtual catapult simulation. The students had improved communication and teamwork skills after following the recommended procedure for practicing DOEs. Practical implications Most students could effectively conduct designing experiments, carry out designed experiments, analyze data and gain valuable teamwork experience. After learning the DOE approach based on the catapult simulation, they enjoyed working on their course projects deploying to the innovative toys and other real-life situations with real measurements. Originality/value The use of Web-based virtual material, including catapult simulation, was an alternative technique for interactive DOE teaching to improve the students’ understanding and achievement in DOE course projects.

Impact of Design of Experiments in the optimisation of catalytic reactions in academia

Design of Experiments (DoE) is extensively and routinely used in industry; however, in the last decades, it has been gaining increasing interest in organic synthesis in academia. The use of Chemometrics is an attractive strategy to find the real optimum in chemical reactions, especially when affected by several variables. DoE has been applied in a growing number of synthetic transformations over the years, where it can undoubtedly help in the process optimisation, saving costs and time. This review concisely discusses the chemometric basis of Design of Experiments and highlights several examples in which DoE has been applied in organic synthesis. Table of contents 1 Introduction 2 Chemometric basis of DoE 3 DoE applied in catalysis: examples 4 Conclusions

Design of experiments for the methylene blue adsorption study onto biocomposite material based on Algerian earth chestnut and cellulose derivatives

Novel bio-composite films based on Algerian earth chestnut i.e. Bunium incrassatum roots (Talghouda, TG) and cellulose derivatives (ethylcellulose; EC and cellulose acetate; AC) are prepared and tested for methylene blue (MB) adsorption from aqueous solutions. The biomaterial films are elaborated by dissolution solvent evaporation technique and are characterized by infrared spectroscopy, X-ray diffraction, SEM and optical microscopy. The pHpzc is also determined. For the adsorption tests, design of experiments based on 23 factorial design is built and followed. So, the effects of TG:EC:AC ratio, pH and MB initial concentration are discussed on the basis of mathematical modelling using Minitab software. Mathematical relations between equilibrium adsorption percentages and capacities versus selected variables were obtained and illustrated by surface plots. The interactive effects between variables have been also identified. The results showed that the MB adsorption percentage exceeded 83% and is mostly affected by pH value. Nevertheless the adsorption capacity is affected by MB initial concentration.

Optimization of Biomass Accumulation and Production of Phenolic Compounds in Callus Cultures of Rhodiola rosea L. Using Design of Experiments

Rhodiola rosea L. is a valuable medicinal plant with adaptogenic, neuroprotective, antitumor, cardioprotective, and antidepressant effects. In this study, design of experiments methodology was employed to analyze and optimize the interacting effects of mineral compounds (concentration of NO3− and the ratio of NH4+ to K+) and two plant growth regulators [total 6-benzylaminopurine (BAP) and α-naphthylacetic acid (NAA) concentration and the ratio of BAP to NAA] on the growth and the production of total phenolic compounds (TPCs) in R. rosea calluses. The overall effect of the model was highly significant (p < 0.0001), indicating that NH4+, K+, NO3−, BAP, and NAA significantly affected growth. The best callus growth (703%) and the highest production of TPCs (75.17 mg/g) were achieved at an NH4+/K+ ratio of 0.33 and BAP/NAA of 0.33, provided that the concentration of plant growth regulators was 30 μM and that of NO3− was ≤40 mM. According to high-performance liquid chromatography analyses of aerial parts (leaves and stems), in vitro seedlings and callus cultures of R. rosea contain no detectable rosarin, rosavin, rosin, and cinnamyl alcohol. This is the first report on the creation of an experiment for the significant improvement of biomass accumulation and TPC production in callus cultures of R. rosea.