Probing for Improved Potency and In Vivo Bioavailability of Excitatory Amino Acid Transporter Subtype 1 Inhibitors UCPH-101 and UCPH-102: Design, Synthesis and Pharmacological Evaluation of Substituted 7-Biphenyl Analogs

Design Synthesis ◽

Pharmacological Evaluation ◽

The Excitatory Amino Acid Transporter-2 Induces Apoptosis and Decreases Glioma Growth In vitro and In vivo

Cancer Research ◽

10.1158/0008-5472.can-04-3626 ◽

2005 ◽

Vol 65 (5) ◽

pp. 1934-1940 ◽

Cited By ~ 60

Author(s):

John F. de Groot ◽

Ta Jen Liu ◽

Gregory Fuller ◽

W.K. Alfred Yung

Keyword(s):

Amino Acid ◽

Excitatory Amino Acid ◽

Amino Acid Transporter ◽

Glioma Growth ◽

Design, synthesis and pharmacological characterization of coumarin-based fluorescent analogs of excitatory amino acid transporter subtype 1 selective inhibitors, UCPH-101 and UCPH-102

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2012.09.049 ◽

2012 ◽

Vol 20 (23) ◽

pp. 6831-6839 ◽

Cited By ~ 23

Author(s):

Tri H.V. Huynh ◽

Bjarke Abrahamsen ◽

Karsten K. Madsen ◽

Alba Gonzalez-Franquesa ◽

Anders A. Jensen ◽

...

Keyword(s):

Amino Acid ◽

Excitatory Amino Acid ◽

Amino Acid Transporter ◽

Selective Inhibitors ◽

Pharmacological Characterization ◽

Design Synthesis ◽

Excitatory amino acid transporter 3 and the glutamate/cystine antiporter system Xc- cooperatively protect neuronal HT22 cells from oxidative glutamate toxicity

Aktuelle Neurologie ◽

10.1055/s-2004-833373 ◽

2004 ◽

Vol 31 (S 1) ◽

Author(s):

M Klein ◽

A Methner ◽

J Lewerenz

Keyword(s):

Amino Acid ◽

Excitatory Amino Acid ◽

Amino Acid Transporter ◽

Glutamate Toxicity ◽

Ht22 Cells ◽

The importance of the excitatory amino acid transporter 3 (EAAT3)

Neurochemistry International ◽

10.1016/j.neuint.2016.05.007 ◽

2016 ◽

Vol 98 ◽

pp. 4-18 ◽

Cited By ~ 30

Author(s):

Walden E. Bjørn-Yoshimoto ◽

Suzanne M. Underhill

Keyword(s):

Amino Acid ◽

Excitatory Amino Acid ◽

Amino Acid Transporter ◽

Excitatory Amino Acid Transporter

Encyclopedia of Biophysics ◽

10.1007/978-3-642-16712-6_100291 ◽

2013 ◽

pp. 715-715

Keyword(s):

Amino Acid ◽

Excitatory Amino Acid ◽

Amino Acid Transporter ◽

Association study of the excitatory amino acid transporter 2 (EAAT2) and glycine transporter 1 (GlyT1) gene polymorphism with schizophrenia in a Polish population

Neuropsychiatric Disease and Treatment ◽

10.2147/ndt.s194924 ◽

2019 ◽

Vol Volume 15 ◽

pp. 989-1000 ◽

Cited By ~ 1

Author(s):

Wojciech Merk ◽

Krzysztof Kucia ◽

Tomasz Mędrala ◽

Małgorzata Kowalczyk ◽

Aleksander Owczarek ◽

...

Keyword(s):

Amino Acid ◽

Gene Polymorphism ◽

Association Study ◽

Excitatory Amino Acid ◽

Amino Acid Transporter ◽

Polish Population ◽

Glycine Transporter 1 ◽

Glycine Transporter ◽

Synthesis and Biological Evaluation of Novel Neuroprotective Pyridazine Derivatives as Excitatory Amino Acid Transporter 2 (EAAT2) Activators

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.7b00383 ◽

2017 ◽

Vol 60 (12) ◽

pp. 5216-5221 ◽

Cited By ~ 5

Author(s):

Alessia Chelini ◽

Simone Brogi ◽

Marco Paolino ◽

Angela Di Capua ◽

Andrea Cappelli ◽

...

Keyword(s):

Amino Acid ◽

Excitatory Amino Acid ◽

Amino Acid Transporter ◽

Biological Evaluation ◽

Synthesis And Biological Evaluation

Acid Transporter ◽

Pyridazine Derivatives ◽

Decrease of aquaporin-4 and excitatory amino acid transporter-2 indicate astrocyte dysfunction for pathogenesis of cortical degeneration in HIV-associated neurocognitive disorders

Neuropathology ◽

10.1111/neup.12321 ◽

2016 ◽

Vol 37 (1) ◽

pp. 25-34 ◽

Cited By ~ 7

Author(s):

Hui Qin Xing ◽

Yu Zhang ◽

Kimiko Izumo ◽

Shiho Arishima ◽

Ryuji Kubota ◽

...

Keyword(s):

Amino Acid ◽

Excitatory Amino Acid ◽

Amino Acid Transporter ◽

Neurocognitive Disorders ◽

Aquaporin 4 ◽

Hiv Associated Neurocognitive Disorders

Acid Transporter ◽

Prion protein regulates glutathione metabolism and neural glutamate and cysteine uptake via excitatory amino acid transporter 3

Journal of Neurochemistry ◽

10.1111/jnc.13071 ◽

2015 ◽

Vol 133 (4) ◽

pp. 558-571 ◽

Cited By ~ 8

Author(s):

Kathrin Guitart ◽

Gabriele Loers ◽

Melitta Schachner ◽

Ralf Kleene

Keyword(s):

Amino Acid ◽

Prion Protein ◽

Excitatory Amino Acid ◽

Amino Acid Transporter ◽

Glutathione Metabolism ◽

Acid Transporter ◽

Cysteine Uptake

Effect of early weaning on the expression of excitatory amino acid transporter 1 in the jejunum and ileum of piglets

Molecular Medicine Reports ◽

10.3892/mmr.2017.7421 ◽

2017 ◽

Vol 16 (5) ◽

pp. 6518-6525 ◽

Cited By ~ 3

Author(s):

Qiu-Ju Wang ◽

Yi-Zhe Cui ◽

Xiu-Ying Zhang ◽

Jing Su

Keyword(s):

Amino Acid ◽

Excitatory Amino Acid ◽

Amino Acid Transporter ◽

Early Weaning ◽