Drug synthesis methods and manufacturing technology preparative chromatographic separation of ibuprofen enantiomers on Whelk-O1 chiral stationary phase

2012 ◽  
Vol 46 (9) ◽  
pp. 568-572 ◽  
Author(s):  
E. N. Reshetova ◽  
A. A. Gorbunov ◽  
L. D. Asnin
Keyword(s):  
Stationary Phase ◽  
Chromatographic Separation ◽  
Chiral Stationary Phase ◽  
Manufacturing Technology ◽  
Synthesis Methods ◽  
Ibuprofen Enantiomers ◽  
Drug Synthesis

Enantioselective Gas Chromatographic Separation of Racemic N-alkylated Barbiturates: Application of C11-Chirasil-Dex as Chiral Stationary Phase in GC

2007 ◽  
Vol 2 ◽  
pp. 117739010700200
Author(s):  
Ashraf Ghanem
Keyword(s):  
Gas Chromatography ◽  
Stationary Phase ◽  
Chromatographic Separation ◽  
Chiral Stationary Phase ◽  
Enantiomeric Separation ◽  
Enantioselective Gas Chromatography ◽  
Gas Chromatographic Separation ◽  
New Stationary Phase

Chirasil-β-Dex containing an undecamethylene spacer (C11-Chirasil-Dex) was synthesized and used as chiral stationary phase (CSP) in enantioselective gas chromatography (GC). The versatility of the new stationary phase in the simultaneous enantiomeric separation of a set of N-alkylated barbiturates is demonstrated.

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