Synthesis and Cardiotropic Activity of Linear Methoxyphenyltriazaalkanes

2019 ◽  
Vol 53 (6) ◽  
pp. 500-506 ◽  
Author(s):  
G. V. Mokrov ◽  
A. M. Likhosherstov ◽  
V. V. Barchukov ◽  
V. N. Stolyaruk ◽  
I. B. Tsorin ◽  
...  
Keyword(s):  
Cardiotropic Activity

Cardiotropic activity of pyridin-2(1H)-ones

1989 ◽  
Vol 23 (12) ◽  
pp. 983-986 ◽  
Author(s):  
�. V. Narushyavichus ◽  
V. N. Garalene ◽  
A. A. Krauze ◽  
G. Ya. Dubur
Keyword(s):  
Cardiotropic Activity

Synthesis and Cardiotropic Activity of 1-(Methoxybenzyl)-4-{2-[(Methoxybenzyl)-Amino]Ethyl}Piperazines

2019 ◽  
Vol 53 (9) ◽  
pp. 786-791
Author(s):  
G. V. Mokrov ◽  
A. M. Likhosherstov ◽  
V. V. Barchukov ◽  
V. N. Stolyaruk ◽  
I. B. Tsorin ◽  
...  
Keyword(s):  
Cardiotropic Activity

Synthesis and Cardiotropic Activity of Cyclic Methoxyphenyltriazaalkanes

2019 ◽  
Vol 53 (7) ◽  
pp. 598-603
Author(s):  
G. V. Mokrov ◽  
A. M. Likhosherstov ◽  
V. V. Barchukov ◽  
V. N. Stolyaruk ◽  
I. B. Tsorin ◽  
...  
Keyword(s):  
Cardiotropic Activity

ChemInform Abstract: STUDY OF THE CONFIGURATION OF OXIMES HAVING CARDIOTROPIC ACTIVITY

1978 ◽  
Vol 9 (18) ◽  
Author(s):  
J. LAFOREST ◽  
G. THUILLIER
Keyword(s):  
Cardiotropic Activity

A water-soluble form of estradiol with estrogenic and cardiotropic activity

1995 ◽  
Vol 119 (1) ◽  
pp. 45-47
Author(s):  
A. I. Matyushin ◽  
Yu. M. Petrenko ◽  
E. V. Popova
Keyword(s):  
Water Soluble ◽  
Soluble Form ◽  
Cardiotropic Activity

ChemInform Abstract: Cardiotropic Activity of Some Substituted Pyridin-2(1H)-ones, e.g. (IV), (V), (VII).

ChemInform ◽  
1990 ◽  
Vol 21 (32) ◽  
Author(s):  
E. V. NARUSHYAVICHUS ◽  
V. N. GARALENE ◽  
A. A. KRAYZE ◽  
G. YA. DUBUR
Keyword(s):  
Cardiotropic Activity

Synthesis and Cardiotropic Activity of bis-(2,3,4-Trimethoxybenzyl)Alkanediamines

2021 ◽  
Author(s):  
G. V. Mokrov ◽  
A. M. Likhosherstov ◽  
E. I. Barchukova ◽  
V. V. Barchukov ◽  
I. B. Tsorin ◽  
...  
Keyword(s):  
Cardiotropic Activity

scholarly journals Biological evaluation of analogues of an insect neuropeptide proctolin.

2004 ◽  
Vol 51 (1) ◽  
pp. 115-119 ◽  
Author(s):  
Iwona Woźnica ◽  
Wioletta Szeszel-Fedorowicz ◽  
Grzegorz Rosińskiand ◽  
Danuta Konopińska
Keyword(s):  
Schistocerca Gregaria ◽  
Tenebrio Molitor ◽  
Biological Evaluation ◽  
Peptide Chain ◽  
Insect Neuropeptide ◽  
Myotropic Activity ◽  
Synthesis And Biological Evaluation ◽  
Cardiotropic Activity

Continuing our studies on proctolin (Arg-Tyr-Leu-Pro-Thr) we performed the synthesis and biological evaluation of 52 analogues substituted in position 2, 3, 4, and 5 of the peptide chain. The peptides were bioassayed for cardiotropic activity in vitro on Tenebrio molitor and myotropic activity on foregut of Schistocerca gregaria. Twenty analogues retained 20-80% of proctolin activity.

scholarly journals Study of ALM-802 orto-alkoxi analogues cardiotropic activity

2020 ◽  
pp. 18-23
Author(s):  
G. V. Mokrov ◽  
A. M. Likhosherstov ◽  
V. V. Barchukov ◽  
V. N. Stolyaruk ◽  
I. B. Tsorin ◽  
...  
Keyword(s):  
Calcium Chloride ◽  
Structural Changes ◽  
Antiarrhythmic Activity ◽  
Phenyl Rings ◽  
Alkoxy Groups ◽  
Cardiotropic Activity

New ortho-alkoxy analogs of the compound ALM-802 1a (N1-(2-methoxybenzyl)-N2-[2-((2-methoxybenzyl)amino)ethyl]ethane-1,2-diamine trihydrochloride) and 1b (N1-(2-ethoxybenzyl)-N2-[2-((2-ethoxybenzyl)amino)ethyl]ethane-1,2-diamine trihydrochloride), which differ from it by the presence of alkoxy groups in the phenyl rings only in the ortho positions. It was established that these structural changes lead to the disappearance of anti-ischemic activity. At the same time, antiarrhythmic activity was revealed in compound 1b on the models of aconitine and calcium chloride arrhythmias in rats (1 mg / kg, intravenously), which was absent in 1a.

scholarly journals A Search for Cardiotropic Biologically Active Substances among New Derivatives of R- phenylimin-1,3-thiazole

2018 ◽  
Author(s):  
Lina O. Perekhoda ◽  
Irina V. Drapak ◽  
Marharyta M. Suleiman ◽  
Marina V. Rakhimova ◽  
Svetlana G. Таran ◽  
...  
Keyword(s):  
1H Nmr Spectroscopy ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Hantzsch Reaction ◽  
Thiazole Derivatives ◽  
Laboratory Rats ◽  
Pharmacological Screening ◽  
Derivatives Of ◽  
Active Substances ◽  
Cardiotropic Activity

The purpose of our work was the search for safe and effective biologically active substances of cardiotropic action among 1,3- thiazole derivatives. New derivatives of 1-[(2Z)-2-[R-imin]-4-methyl-3-R1-2,3-dihydro-1,3-thiazole-5-yl]ethan-1-one and ethyl-(2Z)-2-[R-imin]-4-methyl-3-R1-2,3-dihydro-1,3-thiazole-5-carboxylate were synthesized by the Hantzsch reaction. The structure of the compounds obtained was confirmed by 1H NMR spectroscopy and by the elemental analysis. The pharmacological screening showed that the obtained substances possess cardiotropic activity. The cardiotropic properties of the new 1,3-thiazole derivatives were studied on the isolated rings of the thoracic aorta of laboratory rats. A prospective substance 1-[(2Z)-2-[(4-methoxyphenyl)imin]-4-methyl-3-(4-methylpiperazin-1-yl) -2,3-dihydro-1,3-thiazol-5-yl]ethan-1-one hydrochloride, which exhibits cardiotropic activity exceeding the activity of L-carnitine and meldonia has been revealed during pharmacological researches of the substances obtained.

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