Oral Absorption of Poorly Water-Soluble Drugs: Computer Simulation of Fraction Absorbed in Humans from a Miniscale Dissolution Test

Pharmaceutical Research ◽

10.1007/s11095-006-0162-4 ◽

2006 ◽

Vol 23 (6) ◽

pp. 1144-1156 ◽

Author(s):

Ryusuke Takano ◽

Kiyohiko Sugano ◽

Atsuko Higashida ◽

Yoshiki Hayashi ◽

Minoru Machida ◽

...

Keyword(s):

Computer Simulation ◽

Oral Absorption ◽

Water Soluble ◽

Dissolution Test ◽

Poorly Water Soluble Drugs ◽

Fraction Absorbed ◽

Water Soluble Drugs ◽

Poorly Water Soluble

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Rate-Limiting Steps of Oral Absorption for Poorly Water-Soluble Drugs in Dogs; Prediction from a Miniscale Dissolution Test and a Physiologically-Based Computer Simulation

Pharmaceutical Research ◽

10.1007/s11095-008-9637-9 ◽

2008 ◽

Vol 25 (10) ◽

pp. 2334-2344 ◽

Author(s):

Ryusuke Takano ◽

Kentaro Furumoto ◽

Koji Shiraki ◽

Noriyuki Takata ◽

Yoshiki Hayashi ◽

...

Keyword(s):

Computer Simulation ◽

Oral Absorption ◽

Water Soluble ◽

Dissolution Test ◽

Poorly Water Soluble Drugs ◽

Physiologically Based ◽

Water Soluble Drugs ◽

Poorly Water Soluble ◽

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Evaluating the Role of Solubility in Oral Absorption of Poorly Water‐Soluble Drugs Using Physiologically‐Based Pharmacokinetic Modeling

Clinical Pharmacology & Therapeutics ◽

10.1002/cpt.1672 ◽

2019 ◽

Vol 107 (3) ◽

pp. 650-661 ◽

Author(s):

Christina Fink ◽

Dajun Sun ◽

Knut Wagner ◽

Melanie Schneider ◽

Holger Bauer ◽

...

Keyword(s):

Oral Absorption ◽

Pharmacokinetic Modeling ◽

Water Soluble ◽

Physiologically Based Pharmacokinetic Modeling ◽

Poorly Water Soluble Drugs ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Water Soluble Drugs ◽

Poorly Water Soluble

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Oral Delivery of Highly Lipophilic, Poorly Water-Soluble Drugs: Self-Emulsifying Drug Delivery Systems to Improve Oral Absorption and Enable High-Dose Toxicology Studies of a Cholesteryl Ester Transfer Protein Inhibitor in Preclinical Species

Journal of Pharmaceutical Sciences ◽

10.1016/j.xphs.2018.01.003 ◽

2018 ◽

Vol 107 (5) ◽

pp. 1352-1360 ◽

Author(s):

Xue-Qing Chen ◽

Theresa Ziemba ◽

Christine Huang ◽

Ming Chang ◽

Carrie Xu ◽

...

Keyword(s):

Oral Delivery ◽

Oral Absorption ◽

Water Soluble ◽

High Dose ◽

Protein Inhibitor ◽

Poorly Water Soluble Drugs ◽

Transfer Protein ◽

Water Soluble Drugs ◽

Preclinical Species ◽

Poorly Water Soluble

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Strategy for improving oral absorption of poorly water-soluble drugs using a computer-based simulation

Drug Delivery System ◽

10.2745/dds.25.362 ◽

2010 ◽

Vol 25 (4) ◽

pp. 362-370

Author(s):

Ryusuke Takano

Keyword(s):

Oral Absorption ◽

Water Soluble ◽

Poorly Water Soluble Drugs ◽

Water Soluble Drugs ◽

Computer Based ◽

Poorly Water Soluble

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Application of Dissolution/Permeation System for Evaluation of Formulation Effect on Oral Absorption of Poorly Water-Soluble Drugs in Drug Development

Pharmaceutical Research ◽

10.1007/s11095-011-0623-2 ◽

2011 ◽

Vol 29 (6) ◽

pp. 1485-1494 ◽

Author(s):

Makoto Kataoka ◽

Kiyohiko Sugano ◽

Claudia da Costa Mathews ◽

Jing Wen Wong ◽

Kelly Lane Jones ◽

...

Keyword(s):

Drug Development ◽

Oral Absorption ◽

Water Soluble ◽

Poorly Water Soluble Drugs ◽

Water Soluble Drugs ◽

Poorly Water Soluble

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Solubility Enhancement of Poorly Water-Soluble Drugs by Hot-Melt Extrusion Technology and Effects of Surfactant on Dissolution Test

Yakhak Hoeji ◽

10.17480/psk.2019.63.6.384 ◽

2019 ◽

Vol 63 (6) ◽

pp. 384-389

Author(s):

Sung-min Choi ◽

Yong-Koo Jeon ◽

Ju-Hyun Lee ◽

Chin-Yang Kang ◽

Jun-Bom Park

Keyword(s):

Hot Melt Extrusion ◽

Solubility Enhancement ◽

Water Soluble ◽

Dissolution Test ◽

Melt Extrusion ◽

Poorly Water Soluble Drugs ◽

Water Soluble Drugs ◽

Poorly Water Soluble ◽

Extrusion Technology ◽

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Oral Delivery of Highly Lipophilic Poorly Water-Soluble Drugs: Spray-Dried Dispersions to Improve Oral Absorption and Enable High-Dose Toxicology Studies of a P2Y1 Antagonist

Journal of Pharmaceutical Sciences ◽

10.1002/jps.24199 ◽

2014 ◽

Vol 103 (12) ◽

pp. 3924-3931 ◽

Author(s):

Xue-Qing Chen ◽

Kevin Stefanski ◽

Hong Shen ◽

Christine Huang ◽

Christian Caporuscio ◽

...

Keyword(s):

Oral Delivery ◽

Oral Absorption ◽

Water Soluble ◽

High Dose ◽

Poorly Water Soluble Drugs ◽

Water Soluble Drugs ◽

Poorly Water Soluble ◽

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Effect of Food Intake on the Oral Absorption of Poorly Water-Soluble Drugs: In Vitro Assessment of Drug Dissolution and Permeation Assay System

Journal of Pharmaceutical Sciences ◽

10.1002/jps.20691 ◽

2006 ◽

Vol 95 (9) ◽

pp. 2051-2061 ◽

Author(s):

Makoto Kataoka ◽

Yoshie Masaoka ◽

Shinji Sakuma ◽

Shinji Yamashita

Keyword(s):

Food Intake ◽

Oral Absorption ◽

Water Soluble ◽

Drug Dissolution ◽

Poorly Water Soluble Drugs ◽

Water Soluble Drugs ◽

Effect Of Food ◽

In Vitro Assessment ◽

Poorly Water Soluble

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Soluplus-coated colloidal silica nanomatrix system for enhanced supersaturation and oral absorption of poorly water-soluble drugs

Artificial Cells Nanomedicine and Biotechnology ◽

10.3109/21691401.2012.762369 ◽

2013 ◽

Vol 41 (6) ◽

pp. 363-367 ◽

Author(s):

Min-Soo Kim

Keyword(s):

Colloidal Silica ◽

Oral Absorption ◽

Water Soluble ◽

Poorly Water Soluble Drugs ◽

Water Soluble Drugs ◽

Poorly Water Soluble

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In Vitro Dissolution/Permeation System to Predict the Oral Absorption of Poorly Water-Soluble Drugs: Effect of Food and Dose Strength on It

Biological and Pharmaceutical Bulletin ◽

10.1248/bpb.34.401 ◽

2011 ◽

Vol 34 (3) ◽

pp. 401-407 ◽

Author(s):

Makoto Kataoka ◽

Sachi Itsubata ◽

Yoshie Masaoka ◽

Shinji Sakuma ◽

Shinji Yamashita

Keyword(s):

Oral Absorption ◽

Water Soluble ◽

In Vitro Dissolution ◽

Poorly Water Soluble Drugs ◽

Water Soluble Drugs ◽

Effect Of Food ◽

Poorly Water Soluble

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