scholarly journals Evaluating the Role of Solubility in Oral Absorption of Poorly Water‐Soluble Drugs Using Physiologically‐Based Pharmacokinetic Modeling

2019 ◽  
Vol 107 (3) ◽  
pp. 650-661 ◽  
Author(s):  
Christina Fink ◽  
Dajun Sun ◽  
Knut Wagner ◽  
Melanie Schneider ◽  
Holger Bauer ◽  
...  
Keyword(s):  
Oral Absorption ◽  
Pharmacokinetic Modeling ◽  
Water Soluble ◽  
Physiologically Based Pharmacokinetic Modeling ◽  
Poorly Water Soluble Drugs ◽  
Physiologically Based Pharmacokinetic ◽  
Physiologically Based ◽  
Water Soluble Drugs ◽  
Poorly Water Soluble

scholarly journals Insoluble Polymers in Solid Dispersions for Improving Bioavailability of Poorly Water-Soluble Drugs

Polymers ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 1679
Author(s):  
Thao T.D. Tran ◽  
Phuong H.L. Tran
Keyword(s):  
Solid Dispersion ◽  
Solid Dispersions ◽  
Water Soluble ◽  
Dissolution Enhancement ◽  
Formulation Development ◽  
Poorly Water Soluble Drugs ◽  
Water Soluble Drugs ◽  
Poorly Water Soluble ◽  
Insoluble Polymers

In recent decades, solid dispersions have been demonstrated as an effective approach for improving the bioavailability of poorly water-soluble drugs, as have solid dispersion techniques that include the application of nanotechnology. Many studies have reported on the ability to change drug crystallinity and molecular interactions to enhance the dissolution rate of solid dispersions using hydrophilic carriers. However, numerous studies have indicated that insoluble carriers are also promising excipients in solid dispersions. In this report, an overview of solid dispersion strategies involving insoluble carriers has been provided. In addition to the role of solubility and dissolution enhancement, the perspectives of the use of these polymers in controlled release solid dispersions have been classified and discussed. Moreover, the compatibility between methods and carriers and between drug and carrier is mentioned. In general, this report on solid dispersions using insoluble carriers could provide a specific approach and/or a selection of these polymers for further formulation development and clinical applications.

Oral Absorption of Poorly Water-Soluble Drugs: Computer Simulation of Fraction Absorbed in Humans from a Miniscale Dissolution Test

2006 ◽  
Vol 23 (6) ◽  
pp. 1144-1156 ◽  
Author(s):  
Ryusuke Takano ◽  
Kiyohiko Sugano ◽  
Atsuko Higashida ◽  
Yoshiki Hayashi ◽  
Minoru Machida ◽  
...  
Keyword(s):  
Computer Simulation ◽  
Oral Absorption ◽  
Water Soluble ◽  
Dissolution Test ◽  
Poorly Water Soluble Drugs ◽  
Fraction Absorbed ◽  
Water Soluble Drugs ◽  
Poorly Water Soluble
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