Outcomes of stereotactic radiosurgery and hypofractionated stereotactic radiotherapy for refractory Cushing’s disease

Pituitary ◽  
2019 ◽  
Vol 22 (6) ◽  
pp. 607-613 ◽  
Author(s):  
Alexander D. Sherry ◽  
Mohamed H. Khattab ◽  
Mark C. Xu ◽  
Patrick Kelly ◽  
Joshua L. Anderson ◽  
...  
Keyword(s):  
Stereotactic Radiosurgery ◽  
Cushing’S Disease ◽  
Stereotactic Radiotherapy ◽  
Cushing's Disease ◽  
Hypofractionated Stereotactic Radiotherapy

Clinical outcomes of perioptic tumors treated with hypofractionated stereotactic radiotherapy using CyberKnife® stereotactic radiosurgery

2018 ◽  
Vol 139 (3) ◽  
pp. 679-688 ◽  
Author(s):  
Putipun Puataweepong ◽  
Mantana Dhanachai ◽  
Ake Hansasuta ◽  
Somjai Dangprasert ◽  
Chomporn Sitathanee ◽  
...  
Keyword(s):  
Stereotactic Radiosurgery ◽  
Clinical Outcomes ◽  
Stereotactic Radiotherapy ◽  
Hypofractionated Stereotactic Radiotherapy

scholarly journals Stereotactic Radiosurgery for Cushing's Disease: Results of an International, Multicenter Study

2018 ◽  
Vol 79 (S 01) ◽  
pp. S1-S188
Author(s):  
Gautam Mehta ◽  
Dale Ding ◽  
Mohana Patibandla ◽  
Hideyuki Kano ◽  
Nathaniel Sisterson ◽  
...  
Keyword(s):  
Stereotactic Radiosurgery ◽  
Multicenter Study ◽  
Cushing’S Disease ◽  
Cushing's Disease ◽  
International Multicenter Study ◽  
International Multicenter

scholarly journals Management of Cushing's Disease After Failed Surgery - A Review

2011 ◽  
Vol 38 (1) ◽  
pp. 12-21 ◽  
Author(s):  
Nancy McLaughlin ◽  
Amin B. Kassam ◽  
Daniel M. Prevedello ◽  
Daniel F. Kelly
Keyword(s):  
Cushing’S Disease ◽  
Stereotactic Radiotherapy ◽  
Transsphenoidal Surgery ◽  
Pituitary Surgery ◽  
Cushing's Disease ◽  
Close Collaboration ◽  
Adjuvant Therapies ◽  
Initial Surgery ◽  
Transsphenoidal Adenomectomy ◽  
Failed Surgery

Abstract:Selective transsphenoidal adenomectomy is generally recommended for initial treatment of Cushing's disease (CD) because it achieves a high (70-85%) rate of remission. However, if initial surgery is not successful, the approach to persistent or recurrent CD is more complex. Because residual or recurrent adenoma is typically found at the site of the original adenoma, repeat transsphenoidal surgery is recommended including selective adenomectomy, hemihypophysectomy or total hypophysectomy. If repeat pituitary surgery does not achieve remission, then possible adjuvant therapies include radiosurgery or stereotactic radiotherapy, bilateral adrenalectomy, and/or medical therapy. In all cases of persistent or recurrent CD, successful treatment requires close collaboration of endocrinologists, radiation oncologists and neurosurgeons.

Application of stereotactic radiosurgery and radiotherapy in the treatment of Itsenko — Cushing’s disease

2020 ◽  
pp. 57-65
Author(s):  
А. Abdali ◽  
L. I. Astafieva ◽  
Yu. Yu. Trunin ◽  
A. V. Golanov ◽  
P. L. Kalinin ◽  
...  
Keyword(s):  
Literature Review ◽  
Stereotactic Radiosurgery ◽  
Cushing’S Disease ◽  
Pituitary Tumor ◽  
Initial Treatment ◽  
Adrenocorticotropic Hormone ◽  
Surgical Intervention ◽  
Radiation Treatment ◽  
Cushing's Disease ◽  
Modern Methods

Cushing’s disease is caused by a pituitary tumor which causes increased production of adrenocorticotropic hormone, leading to chronic hypersecretion of cortisol by the adrenal cortices. Endoscopic transnasal adenomectomy is the initial treatment of choice with the greatest efficiency for the treatment of the disease. However in the absence of remission or relapse of hypercortisolism after neurosurgical surgery, as well as in cases when surgical intervention cannot be carried due to medical contraindications to surgical intervention, radiation treatment is used as an alternative or adjoining therapy. In this literature review the efficiency of different radiation techniques (the conventional and the modern techniques), as well as possible complications of modern methods of radiosurgery and radiotherapy have been looked for.

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