Synthesis of O-(2-[18F]fluoroethyl)-L-tyrosine and its biological evaluation in B16 melanoma-bearing mice as PET tracer for tumor imaging

2007 ◽  
Vol 50 (2) ◽  
pp. 276-283 ◽  
Author(s):  
MingWei Wang ◽  
DuanZhi Yin ◽  
ShiQiang Li ◽  
YongXian Wang
Keyword(s):  
Tumor Imaging ◽  
Biological Evaluation ◽  
B16 Melanoma ◽  
Pet Tracer

scholarly journals Synthesis and preliminary biological evaluation of O-2((2-[18F]fluoroethyl)methylamino)ethyltyrosine ([18F]FEMAET) as a potential cationic amino acid PET tracer for tumor imaging

Amino Acids ◽  
2014 ◽  
Vol 46 (8) ◽  
pp. 1947-1959 ◽  
Author(s):  
Aristeidis Chiotellis ◽  
Adrienne Müller ◽  
Karin Weyermann ◽  
Dominique S. Leutwiler ◽  
Roger Schibli ◽  
...  
Keyword(s):  
Amino Acid ◽  
Tumor Imaging ◽  
Biological Evaluation ◽  
Cationic Amino Acid ◽  
Pet Tracer ◽  
Amino Acid Pet

scholarly journals Radiosynthesis and preliminary biological evaluation of N-(2-[18F]fluoropropionyl)-L-glutamine as a PET tracer for tumor imaging

Oncotarget ◽  
2016 ◽  
Vol 7 (23) ◽  
pp. 34100-34111 ◽  
Author(s):  
Caihua Tang ◽  
Ganghua Tang ◽  
Siyuan Gao ◽  
Shaoyu Liu ◽  
Fuhua Wen ◽  
...  
Keyword(s):  
Tumor Imaging ◽  
Biological Evaluation ◽  
Pet Tracer

2-[18F]Fluorophenylalanine: Synthesis by Nucleophilic 18F-Fluorination and Preliminary Biological Evaluation

Synthesis ◽  
2019 ◽  
Vol 51 (03) ◽  
pp. 664-676 ◽  
Author(s):  
Bernd Neumaier ◽  
Daniel Modemann ◽  
Boris Zlatopolskiy ◽  
Elizaveta Urusova ◽  
Johannes Zischler ◽  
...  
Keyword(s):  
Amino Acids ◽  
Schiff Base ◽  
Biological Evaluation ◽  
Schiff Base Complexes ◽  
Biological Study ◽  
Automated Synthesis ◽  
Pet Tracer ◽  
Iodonium Salt ◽  
Acidic Conditions

2-[18F]Fluorophenylalanine (2-[18F]FPhe), a promising PET tracer for imaging of cerebral infarction and tumors, was efficiently prepared from an easily accessible iodonium salt precursor using Cu-mediated radiofluorination under ‘low base’ or ‘minimalist’ conditions. Whereas significant racemization was initially observed if the ‘minimalist’ protocol was applied for radiolabeling, it was completely suppressed by the careful adjustment of 18F– preprocessing. The initial biological study revealed a higher uptake of 2-[18F]FPhe in different tumor cells in comparison to that of [18F]FET. In contrast to 4-[18F]FPhe, which suffered from rapid defluorination in vivo, 2-[18F]FPhe demonstrated a sufficient in vivo stability. Conclusively, 2-[18F]FPhe is a promising PET probe that is now readily available using Cu-mediated radiofluorination under ‘minimalist’ or ‘low base’ conditions. The simplicity of the translation of the proposed procedures to automated synthesis modules allows a broad biological evaluation of 2-[18F]FPhe. Notably, a novel protocol for the preparation of N-Boc protected amino acids from the respective Ni-Schiff base complexes was developed that avoided application of strongly acidic conditions.

scholarly journals Preparation and Preliminary Biological Evaluation of Novel 99mTc-Labelled Thymidine Analogs as Tumor Imaging Agents

Molecules ◽  
2012 ◽  
Vol 17 (7) ◽  
pp. 8518-8532 ◽  
Author(s):  
Chunxiong Lu ◽  
Quanfu Jiang ◽  
Cheng Tan ◽  
Jie Tang ◽  
Jiankang Zhang
Keyword(s):  
Tumor Imaging ◽  
Biological Evaluation ◽  
Imaging Agents ◽  
Thymidine Analogs

Radiosynthesis and biological evaluation of N -(2-[ 18 F]fluoropropionyl)-3,4-dihydroxy- l -phenylalanine as a PET tracer for oncologic imaging

2017 ◽  
Vol 50 ◽  
pp. 39-46 ◽  
Author(s):  
Caihua Tang ◽  
Dahong Nie ◽  
Ganghua Tang ◽  
Siyuan Gao ◽  
Shaoyu Liu ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Oncologic Imaging ◽  
Pet Tracer

scholarly journals Synthesis and Biological Evaluation of (S)-Amino-2-methyl-4-[76Br]bromo-3-(E)-butenoic Acid (BrVAIB) for Brain Tumor Imaging

2015 ◽  
Vol 58 (21) ◽  
pp. 8542-8552 ◽  
Author(s):  
Jennifer L. Bartels ◽  
Chaofeng Huang ◽  
Aixiao Li ◽  
Liya Yuan ◽  
Keith Rich ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Tumor Imaging ◽  
Biological Evaluation ◽  
Butenoic Acid ◽  
Synthesis And Biological Evaluation

Synthesis and biological evaluation of 99mTc(CO)3(His–CB) as a tumor imaging agent

2012 ◽  
Vol 22 (24) ◽  
pp. 7406-7409 ◽  
Author(s):  
Jianjun Wang ◽  
Jing Yang ◽  
Xiaojiang Duan ◽  
Yanhua Zhang ◽  
Wenjiang Yang ◽  
...  
Keyword(s):  
Tumor Imaging ◽  
Biological Evaluation ◽  
Imaging Agent ◽  
Synthesis And Biological Evaluation ◽  
Tumor Imaging Agent

Radioiodination and biological evaluation of Cladribine as potential agent for tumor imaging and therapy

2015 ◽  
Vol 103 (11) ◽  
Author(s):  
Noha Anwer Bayoumi ◽  
Abeer M. Amin ◽  
Nasser S. M. Ismail ◽  
Khaled A. M. Abouzid ◽  
Mohamed T. El-Kolaly
Keyword(s):  
Tumor Imaging ◽  
Biological Evaluation ◽  
Purine Analogue

AbstractCladribine, a purine analogue antimetabolite, was radioiodinated with

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