A novel β2-AR agonist, Higenamine, induces β-arrestin-biased signaling

2021 ◽  
Author(s):  
Nana Zhang ◽  
Haibo Zhu ◽  
Zijian Li ◽  
Erdan Dong
Keyword(s):  
Biased Signaling

Tuning Down the Pain – An Overview of Allosteric Modulation of Opioid Receptors: Mechanisms of Modulation, Allosteric Sites, Modulator Syntheses

2020 ◽  
Vol 20 (31) ◽  
pp. 2852-2865 ◽  
Author(s):  
Damian Bartuzi ◽  
Tomasz M. Wróbel ◽  
Agnieszka A. Kaczor ◽  
Dariusz Matosiuk
Keyword(s):  
Side Effects ◽  
Opioid Receptors ◽  
Pain Perception ◽  
Allosteric Modulation ◽  
Allosteric Modulators ◽  
Signaling Mechanisms ◽  
Main Target ◽  
Allosteric Sites ◽  
Biased Signaling ◽  
Opioid Signaling

Opioid signaling plays a central role in pain perception. As such, it remains the main target in the development of antinociceptive agents, despite serious side effects involved. In recent years, hopes for improved opioid painkillers are rising, together with our understanding of allosterism and biased signaling mechanisms. In this review, we focus on recently discovered allosteric modulators of opioid receptors, insights into phenomena underlying their action, as well as on how they extend our understanding of mechanisms of previously known compounds. A brief overlook of their synthesis is also presented.

Can Adding Constitutive Receptor Activity Redefine Biased Signaling Quantification?

2019 ◽  
Vol 40 (3) ◽  
pp. 156-160 ◽  
Author(s):  
Bin Zhou ◽  
David A. Hall ◽  
Jesús Giraldo
Keyword(s):  
Receptor Activity ◽  
Biased Signaling

Adrenal angiotensin II type 1 receptor biased signaling: The case for “biased” inverse agonism for effective aldosterone suppression

2021 ◽  
Vol 82 ◽  
pp. 109967 ◽  
Author(s):  
Krysten E. Ferraino ◽  
Natalie Cora ◽  
Celina M. Pollard ◽  
Anastasiya Sizova ◽  
Jennifer Maning ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Inverse Agonism ◽  
Biased Signaling

scholarly journals G Protein Biased Signaling by Non‐catechol Dopamine D1 Receptor Agonists

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Ashley N. Nilson ◽  
Pingyuan Wang ◽  
Manish K. Jain ◽  
Jia Zhou ◽  
John A. Allen
Keyword(s):  
G Protein ◽  
Dopamine D1 Receptor ◽  
D1 Receptor ◽  
Receptor Agonists ◽  
Biased Signaling
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