Serum 25-hydroxyvitamin D, bone mineral density, and non-vertebral fracture risk in community-dwelling older men: results from Mr. Os, Hong Kong

Abstract Background Weight loss increases fracture risk in older adults. We aimed to determine associations of 2-year body composition trajectories with subsequent falls and fractures in older men. Methods We measured appendicular lean mass (ALM) and total fat mass (FM) by dual-energy X-ray absorptiometry at baseline and Year 2 in 1,326 community-dwelling men aged ≥70 and older. Body composition trajectories were determined from residuals of a linear regression of change in ALM on change in FM (higher values indicate maintenance of ALM over FM), and a categorical variable for change in ALM and FM (did not lose [≥−5% change] versus lost [<−5% change]). Bone mineral density (BMD), hand grip strength, and gait speed were assessed at Years 2 and 5. After Year 2, incident fractures (confirmed by radiographical reports) and falls were recorded for 6.8 years. Results Compared with men who did not lose ALM or FM, men who did not lose ALM but lost FM, and men who lost both ALM and FM, had reduced falls (−24% and −34%, respectively; both p < .05). Men who lost ALM but did not lose FM had increased falls (incidence rate ratio = 1.73; 95% CI 1.37–2.18). ALM/FM change residuals were associated with improved lumbar spine BMD (B = 0.007; 95% CI 0.002–0.012 g/cm2 per SD increase) and gait speed (0.015; 0.001–0.029 m/s), and reduced hip fractures (hazard ratio = 0.68; 95% CI 0.47–0.99). Conclusions Fracture risk may be increased in older men who lose higher ALM relative to FM. Weight loss interventions for obese older men should target maintenance of lean mass.

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Association of Cdx1 binding site of periostin gene with bone mineral density and vertebral fracture risk

Bone ◽

10.1016/j.bone.2011.03.349 ◽

2011 ◽

Vol 48 ◽

pp. S158-S159

Author(s):

S.-M. Xiao ◽

Y. Gao ◽

C.-L. Cheung ◽

C.H. Bow ◽

K.-S. Lau ◽

...

Keyword(s):

Bone Mineral Density ◽

Vertebral Fracture ◽

Fracture Risk ◽

Binding Site ◽

Bone Mineral ◽

Mineral Density ◽

Vertebral Fracture Risk

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The percentage reduction in vertebral fracture risk with lasofoxifene explained by change in spine bone mineral density

Bone ◽

10.1016/j.bone.2010.04.490 ◽

2010 ◽

Vol 47 ◽

pp. S207

Author(s):

R.M. Jacques ◽

D. Reid ◽

J. Zanchetta ◽

S. Vukicevic ◽

D. Thompson ◽

...

Keyword(s):

Bone Mineral Density ◽

Vertebral Fracture ◽

Fracture Risk ◽

Bone Mineral ◽

Spine Bone Mineral Density ◽

Percentage Reduction ◽

Mineral Density ◽

Vertebral Fracture Risk

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Glucocorticoid-Induced Bone Loss Is Associated with Abnormal Intravertebral Areal Bone Mineral Density Distribution

International Journal of Endocrinology ◽

10.1155/2013/768579 ◽

2013 ◽

Vol 2013 ◽

pp. 1-9 ◽

Cited By ~ 4

Author(s):

Louise I. Manning ◽

Andrew M. Briggs ◽

Sharon Van Doornum ◽

Ashwini Kale ◽

Susan Kantor ◽

...

Keyword(s):

Bone Mineral Density ◽

Vertebral Fracture ◽

Bone Loss ◽

Fracture Risk ◽

Bone Mineral ◽

Vertebral Body ◽

Areal Bone Mineral Density ◽

Primary Osteoporosis ◽

Mineral Density ◽

Vertebral Fracture Risk

Individuals with glucocorticoid-induced osteoporosis experience vertebral fractures at an increased rate and at higher vertebral areal bone mineral density (aBMD) than individuals with primary osteoporosis. Standard posteroanterior- (PA-) projection dual energy X-ray absorptiometry (DXA) lacks the diagnostic sensitivity required for reliable estimation of vertebral fracture risk in individuals. Assessment of subregional vertebral aBMD using lateral-projection DXA may improve the predictive value of DXA parameters for fracture. One hundred and four individuals were recruited and grouped for this study: primary osteoporosis with no history of vertebral fracture (n=43), glucocorticoid-induced bone loss (n=13), and healthy controls (n=48). Standard PA-projection and supine-lateral scans were performed, and lateral scans were analysed according to an established protocol to measure aBMD within 6 subregions. Main effects for subregion and group were assessed and observed, by ANCOVA. Ratios were calculated between subregions and compared between groups, to overcome the potentially confounding influence of variability in subregional geometry. Significantly lower values were observed in the glucocorticoid group for the ratios of (i) anterior subregion: whole vertebral body and (ii) posterior: whole vertebral body when compared to the primary osteoporosis and control groups (P<0.05). Lower anterior subregional aBMD in individuals on glucocorticoid therapy may help to explain the increased vertebral fracture risk in this patient group.

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