Author Reply—Bariatric Surgery and Liver Function Tests in Nonalcoholic Fatty Liver Disease

Background: Patients with nonalcoholic fatty liver disease (NAFLD) and with abnormal liver function tests (LFTs) most commonly present with elevated hepatocellular enzymes (H pattern), but a subset of patients is found to have elevated cholestatic enzymes (C pattern) or a mixed (M) pattern. Aims and Methods: To determine whether the epidemiologic background and comorbidities, as well as the degree of liver fibrosis, differ between NAFLD patients with different patterns of elevated LFTs by retrospectively analyzing data of 106 patients with a biopsy-proven diagnosis of NAFLD. The pattern of elevated LFTs was determined by adopting the “R-Ratio” formula commonly used for drug-induced liver injury. Results: Advanced fibrosis (F > 2) was found in 15 out of 48 (31.3%) patients with a C pattern of elevated LFTs as compared to 2 out of 44 (4.5%) in M patients and 2 out of 11 (18.2%) in H patients (p = 0.004). Group C patients are older and also had a higher prevalence of diabetes, a higher mean hemoglobin A1c, and a higher prevalence of hypertension, as well as a trend for a higher prevalence of hypertriglyceridemia. Conclusions: Using a simple formula incorporating routine LFTs can help to categorize NAFLD patients as low or high risk for advanced fibrosis stage and metabolic-associated comorbidities.

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1260-P: Labcorp Data in >19,000 Children with a Diagnosis Code for T2D Show Predominantly Normal Liver Function Tests: Implications for Identifying Nonalcoholic Fatty Liver Disease or Steatohepatitis (NAFLD/NASH)

Diabetes ◽

10.2337/db20-1260-p ◽

2020 ◽

Vol 69 (Supplement 1) ◽

pp. 1260-P

Author(s):

MALA PURI ◽

KARINA M. LIZZI-ANSOK ◽

CLAUDIA M. FILOZOF ◽

BARRY J. GOLDSTEIN

Keyword(s):

Liver Disease ◽

Liver Function ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Fatty Liver Disease ◽

Normal Liver ◽

Liver Function Tests ◽

Diagnosis Code ◽

Normal Liver Function ◽

Nonalcoholic Fatty Liver

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Alterations of liver function tests in diabetic obese and nonobese individuals

Biomedicine ◽

10.51248/.v41i4.681 ◽

2021 ◽

Vol 41 (4) ◽

pp. 781-786

Author(s):

Avinash S. ◽

Santhi Silambanan

Keyword(s):

Liver Disease ◽

Liver Function ◽

Fatty Liver ◽

Fatty Liver Disease ◽

Cost Effective ◽

Liver Function Tests ◽

P Value ◽

Alcoholic Fatty Liver ◽

Nonalcoholic Fatty Liver ◽

Function Tests

Introduction and Aim: India has emerged as the diabetes capital in Southeast Asia having around 74 million with diabetes, with a prevalence of 9.8% in 18–99 years of age. In type 2 diabetes mellitus, triglycerides get deposited in liver thus altering its structure and function, which is the feature of nonalcoholic fatty liver disease. This study was undertaken to study the alterations in liver function tests in obese and nonobese diabetic individuals. Materials and Methods: The Department of Biochemistry at Sri Ramachandra Institute of Higher Education and Research was chosen to conduct the retrospective study on 200 diabetic individuals from September 2019 to February 2020. The data obtained were serum liver function tests, HbA1c, plasma glucose and lipid profile. Before the study ethics approval was obtained from the Institutional Ethics Committee for studies involving human participants. The obtained data were subjected to statistical analysis using SPSS version 16 and a P value less than 0.05 was considered statistically significant. Results: Transaminases and ALP were significantly altered in obese diabetics; were positively correlated with bilirubin. TGL was negatively correlated with AST/ALT ratio. Conclusion: Liver enzymes and bilirubin were altered in obese diabetics. Measurement of liver function biomarkers are cost effective diagnostic markers of non-alcoholic fatty liver disease.

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