The article reviews the recent data (from 01.01.2002- 30.07.2004) concerning the role of HRT in prevention of postmenopausal bone loss and fractures. All the articles, that are included from Medline and Pub Med have been checked up in Cochran Controlled Register. The role of HRT remains great in treatment osteopenia. The effectiveness of HRT and depends on the length of duration, doses of estrogens, age of the patient.