Antioxidative and Cardioprotective Effects of Total Flavonoids Extracted from Dracocephalum moldavica L. Against Acute Ischemia/Reperfusion-Induced Myocardial Injury in Isolated Rat Heart

2014 ◽  
Vol 14 (1) ◽  
pp. 74-82 ◽  
Author(s):  
Jiangtao Jiang ◽  
Xuan Yuan ◽  
Ting Wang ◽  
Hongmei Chen ◽  
Hong Zhao ◽  
...  
Keyword(s):  
Rat Heart ◽  
Myocardial Injury ◽  
Ischemia Reperfusion ◽  
Isolated Rat Heart ◽  
Acute Ischemia ◽  
Total Flavonoids ◽  
Cardioprotective Effects ◽  
Isolated Rat

scholarly journals Cardioprotective Effects of Astragalin against Myocardial Ischemia/Reperfusion Injury in Isolated Rat Heart

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Daoxu Qu ◽  
Jichun Han ◽  
Huanhuan Ren ◽  
Wenxiao Yang ◽  
Xinjie Zhang ◽  
...  
Keyword(s):  
Myocardial Ischemia ◽  
Rat Heart ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Isolated Rat Heart ◽  
Sprague Dawley ◽  
Sod Activity ◽  
Cardioprotective Effects ◽  
Myocardial Ischemia Reperfusion ◽  
Isolated Rat

This study aims to evaluate the cardioprotective effects of astragalin against myocardial ischemia/reperfusion (I/R) injury in isolated rat heart. The cardioprotective effects of astragalin on myocardial I/R injury were investigated on Langendorff apparatus. Adult male Sprague-Dawley rats were randomly divided into five groups. The results showed that astragalin pretreatment improved myocardial function. Compared with I/R group, lactate dehydrogenase (LDH) and creatine kinase (CK) activities in coronary flow decreased in astragalin pretreatment groups, whereas superoxide dismutase (SOD) activity and glutathione/glutathione disulfide (GSH/GSSG) ratio significantly increased. The levels of malondialdehyde (MDA), intracellular reactive oxygen species (ROS), tumor necrosis factor-α(TNF-α), and interleukin-6 (IL-6) decreased in astragalin-treated groups. The infarct size (IS) and apoptosis rate in hearts from astragalin-treated groups were lower than those in hearts from the I/R group. Western blot analysis also revealed that astragalin preconditioning significantly reduced Bax level, whereas Bcl-2 was increased in the myocardium. Therefore, astragalin exhibited cardioprotective effects via its antioxidative, antiapoptotic, and anti-inflammatory activities.

scholarly journals Cardioprotective effects of bilberry extract on ischemia-reperfusion-induced injury in isolated rat heart

2009 ◽  
Vol 9 (S2) ◽  
Author(s):  
Lovro Žiberna ◽  
Mojca Lunder ◽  
Špela Može ◽  
Andreja Vanzo ◽  
Gorazd Drevenšek
Keyword(s):  
Rat Heart ◽  
Ischemia Reperfusion ◽  
Isolated Rat Heart ◽  
Cardioprotective Effects ◽  
Bilberry Extract ◽  
Isolated Rat

scholarly journals Direct comparison of cardioprotective effects of necroptosis inhibitors against global ischemia-reperfusion in the isolated rat heart

2017 ◽  
Vol 16 (4) ◽  
pp. 126-133 ◽  
Author(s):  
Yu. V. Dmitriev ◽  
S. M. Minasian ◽  
V. K. Bayrasheva ◽  
E. A. Demchenko ◽  
M. M. Galagudza
Keyword(s):  
Rat Heart ◽  
Ischemia Reperfusion ◽  
Isolated Rat Heart ◽  
Global Ischemia ◽  
Cardioprotective Effects ◽  
Isolated Rat
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